公开(公告)号：US11998479B2

公开(公告)日：2024-06-04

申请号：US18234544

申请日：2023-08-16

Applicant: SEED HEALTH, INC.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61F5/56

CPC classification number: A61F5/566

Abstract: A method and system to address the adverse effects on an individual's oral microbiome with the objective of restoring gingival health caused by exposure to sodium lauryl sulfate. Certain embodiments of the present invention facilitate the growth of desired bacteria in a human's mouth to reduce the likelihood of dental caries, halitosis, canker sores, and other oral diseases. Probiotic bacterial, bioactive flavonoid, xylitol and zinc compound compositions, provide effective prevention and treatment options, especially while precluding the use of sodium lauryl sulfate so as to reduce adverse consequences it has on gingival health.

公开(公告)号：US11833177B2

公开(公告)日：2023-12-05

申请号：US18130946

申请日：2023-04-05

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus Crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US20230390343A1

公开(公告)日：2023-12-07

申请号：US18232433

申请日：2023-08-10

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of at least two live bacteria selected from the group consisting of L. reuteri, L johnsonii and L. crispatus, and at least one prebiotic having glycogen as a component thereof. The bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina. Certain embodiments include increasing the production of SCFAs in the individual's gut microbiome, while reducing the production of SCFAs in the individual's vagina and introducing ammonia oxidizing microorganisms to the individual's vagina.

公开(公告)号：US20230241129A1

公开(公告)日：2023-08-03

申请号：US18130946

申请日：2023-04-05

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/1758 ,  A61K38/1709 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus Crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US12005085B2

公开(公告)日：2024-06-11

申请号：US18232433

申请日：2023-08-10

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of at least two live bacteria selected from the group consisting of L. reuteri, L johnsonii and L. crispatus, and at least one prebiotic having glycogen as a component thereof. The bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina. Certain embodiments include increasing the production of SCFAs in the individual's gut microbiome, while reducing the production of SCFAs in the individual's vagina and introducing ammonia oxidizing microorganisms to the individual's vagina.

公开(公告)号：US11998574B2

公开(公告)日：2024-06-04

申请号：US18235686

申请日：2023-08-18

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Raja Dhir ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US20240366687A1

公开(公告)日：2024-11-07

申请号：US18738464

申请日：2024-06-10

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

Abstract: A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of three distinct species of Lactobacillus crispatus bacteria. In certain embodiments, the bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina.

公开(公告)号：US20240285697A1

公开(公告)日：2024-08-29

申请号：US18620483

申请日：2024-03-28

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Joseph E. Kovarik

IPC: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

CPC classification number: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1709 ,  A61K38/1758 ,  C12N1/20 ,  A61K2035/11 ,  A61K2035/115

Abstract: The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. In various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. caseiand Faecalibacterium prausnitzii, to reduce adverse psychological and/or physiological responses attendant to psychological stress.

公开(公告)号：US20230131201A1

公开(公告)日：2023-04-27

申请号：US18087545

申请日：2022-12-22

Applicant: SEED HEALTH, INC.

Inventor： Sheri Simmons ,  Shanthi Parkar ,  Erin A. Miller ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. A topical application of Lactobacillus crispatus is employed to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne. The topical application of Lactobacillus crispatus to an individual's skin reduces inflammation through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US20240024378A1

公开(公告)日：2024-01-25

申请号：US18235686

申请日：2023-08-18

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/1758 ,  A61K38/1709 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.