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14 条记录 (耗时 0.018 秒)

    Fluorescent photochromic fulgides, particularly for optical memories
    1.
    发明授权
    Fluorescent photochromic fulgides, particularly for optical memories 失效
    荧光光致变色俘获物，尤其适用于光记忆体

    公开(公告)号：US06693201B1

    公开(公告)日：2004-02-17

    申请号：US09391280

    申请日：1999-09-07

    申请人： Peter M. Rentzepis ,  Alexander Dvornikov

    发明人： Peter M. Rentzepis ,  Alexander Dvornikov

    IPC分类号： C07D40506

    CPC分类号： C07D405/06 ,  G02B5/23 ,  G11B7/246 ,  G11B2007/24624

    摘要： Photochromic chemicals consisting essentially of colored fluorescent heterocyclic fulgides are particularly suitable for optical memories. The preferred heterocyclic photochromic fulgides consist essentially of colored 2-indolyfulgides capable of excitation by ultraviolet light to fluoresce. These heterocyclic photochromic fulgides are preferably synthesized by process of (1) condensation of 1,3-dimethyl-(5-substituted)indole-2-carboxaldehyde with diethyl IV iospropylidenesuccinate as a key intermediate; followed by (2) hydrolysis; and (3) intramolecular acid anhydride formation.

    摘要翻译： 基本上由有色荧光杂环捕捉剂组成的光致变色化学品尤其适用于光学存储器。 优选的杂环光致变色捕捉剂基本上由能够通过紫外光激发而发出荧光的有色2-取代残基组成。 这些杂环光致变色捕捉剂优选通过以下方法合成：（1）1,3-二甲基 - （5-取代的）吲哚-2-甲醛与作为关键中间体的IV ios-丙二烯基琥珀酸二乙酯的缩合; （2）水解; 和（3）分子内酸酐形成。

    Chromenylmethyl pyrimidinediamines as antibacterial agents
    3.
    发明授权
    Chromenylmethyl pyrimidinediamines as antibacterial agents 失效
    色烯基甲基嘧啶二酮作为抗菌剂

    公开(公告)号：US06818649B2

    公开(公告)日：2004-11-16

    申请号：US10258777

    申请日：2002-10-28

    申请人： Peter Mohr ,  Philippe Pflieger

    发明人： Peter Mohr ,  Philippe Pflieger

    IPC分类号： C07D40506

    CPC分类号： C07D405/06 ,  C07D409/14 ,  C07D491/10 ,  C07D493/10 ,  C07F7/0814

    摘要： This invention is concerned with substituted chromene derivatives of the general formula (I) in which R1-R4 are as defined in the specification and claims. The invention further relates to the pharmaceutically acceptable acid addition salts of these compounds, their use as therapeutically active substances; medicaments based on these substances, optionally in combination with sulphonamides, and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable acid addition salts and intermediates for their manufacture.

    摘要翻译： 本发明涉及通式（I）的取代的色烯衍生物，其中R 1 -R 4如说明书和权利要求中所定义。 本发明还涉及这些化合物的药学上可接受的酸加成盐，它们作为治疗活性物质的用途; 基于这些物质的药物，任选地与磺酰胺组合，以及它们的生产; 使用这些物质作为药物和生产抗菌活性药物; 以及式（I）化合物及其药学上可接受的酸加成盐和其制备中间体的制备。

    Cyclic ether compounds as sodium channel modulators
    9.
    发明授权
    Cyclic ether compounds as sodium channel modulators 失效
    环状醚化合物作为钠通道调节剂

    公开(公告)号：US06172085B2

    公开(公告)日：2001-01-09

    申请号：US09242067

    申请日：1999-02-08

    申请人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    发明人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    IPC分类号： C07D40506

    CPC分类号： C07D405/06 ,  C07D307/81 ,  C07D407/12

    摘要： A compound of the formula: wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.

    摘要翻译： 下式的化合物：其中R1和R2各自表示氢，可被取代的或低级烷基的酰基; R 3，R 4和R 5各自表示可以被取代的低级烷基或可被取代的低级烷氧基，或者R 4和R 5一起代表5-或6-元碳环基; R6代表低级烷基; Ar表示可以被取代的芳基; 环A表示可以被取代的5至8元含氮杂环; X表示可以被取代的低级亚烷基; Y表示碳或氮; Za表示CH2，COCH2，OCH2，SCH2，NHCH2等; Zb表示可以被取代并可以含有O，N或S的键或二价脂族烃基; m表示1〜3的整数，或其盐可用于调制钠通道的药物组合物。