Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine

发明授权

US06608200B1 Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine 有权

标题翻译：制备N-（2,3-二氢苯并[1,4]二恶英-2-羰基）哌嗪的方法

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专利标题： Process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine
专利标题（中）： 制备N-（2,3-二氢苯并[1,4]二恶英-2-羰基）哌嗪的方法
申请号： US10266991

申请日： 2002-10-07
公开(公告)号： US06608200B1

公开(公告)日： 2003-08-19
发明人: Malladi Pardhasaradhi , Gullapalli Kumaraswamy , Arun Kanti Das , Nivedita Jena , Chembumkulam Kamalakshyamma Snehalatha Nair , Mudiganti Naga Venkata Sastry
申请人： Malladi Pardhasaradhi , Gullapalli Kumaraswamy , Arun Kanti Das , Nivedita Jena , Chembumkulam Kamalakshyamma Snehalatha Nair , Mudiganti Naga Venkata Sastry
主分类号： C07D40506
IPC分类号： C07D40506

摘要：

Described herein is an improved process for the preparation of N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine which includes heating a reaction mixture ethyl of 2,3-dihydrobenzo[1,4]dioxin-2-carboxylate and piperazine. The reaction mixture is then subjected to series of washes and extraction to yield N-(2,3-Dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine having a purity of greater than 99.9%.

摘要（中）：

本文描述了制备N-（2,3-二氢苯并[1,4]二恶英-2-羰基）哌嗪的改进方法，其包括加热2,3-二氢苯并[1,4]二恶英 - 2-羧酸乙酯和哌嗪。然后将反应混合物进行一系列洗涤和萃取，得到纯度大于99.9％的N-（2,3-二氢苯并[1,4]二恶英-2-羰基）哌嗪。

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