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6 条记录 (耗时 0.014 秒)

    Preparation of tocopherols
    1.
    发明授权
    Preparation of tocopherols 失效
    生育酚的制备

    公开(公告)号：US06262279B1

    公开(公告)日：2001-07-17

    申请号：US09348192

    申请日：1999-07-06

    申请人： John Anthony Hyatt

    发明人： John Anthony Hyatt

    IPC分类号： C07D31174

    CPC分类号： C07D311/72 ,  C07D303/16 ,  Y02P20/55

    摘要： The invention provides methods for producing tocopherol compounds of the Vitamin E family by reduction of various 4-chromanone trienol materials. In preferred embodiments the invention provides methods of preparing and hydrogenating 4-chromanone trienols to provide gamma-tocopherol.

    摘要翻译： 本发明提供通过还原各种4-苯并二氢吡喃酮三烯酚材料生产维生素E家族的生育酚化合物的方法。 在优选的实施方案中，本发明提供了制备和氢化4-色满酮三烯醇以提供γ-生育酚的方法。

    Synthesis of 4H-chromene derivatives
    2.
    发明授权
    Synthesis of 4H-chromene derivatives 失效

    公开(公告)号：US06660871B2

    公开(公告)日：2003-12-09

    申请号：US10062641

    申请日：2002-02-01

    申请人： Ziwei Huang

    发明人： Ziwei Huang

    IPC分类号： C07D31174

    CPC分类号： C07D311/58

    摘要： Substituted 4H-chromene derivatives are a new class of compounds that bind to Bcl-2 protein and induce apoptosis in tumor cells. The present invention is directed to an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alkyl cyanoacetates under solid phase.

    Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents
    4.
    发明授权
    Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents 失效
    使用取代的乙烯基 - 四氢萘和乙烯基 - 苯并四氢吡喃作为防光剂

    公开(公告)号：US06680390B2

    公开(公告)日：2004-01-20

    申请号：US10173277

    申请日：2002-06-18

    申请人： Frank Prechtl ,  Thorsten Habeck ,  Horst Westenfelder ,  Thomas Wilnsch

    发明人： Frank Prechtl ,  Thorsten Habeck ,  Horst Westenfelder ,  Thomas Wilnsch

    IPC分类号： C07D31174

    CPC分类号： A61K8/40 ,  A61K8/368 ,  A61K8/37 ,  A61K8/498 ,  A61K2800/52 ,  A61Q17/04

    摘要： The invention relates to the use of compounds of the formula I in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical ═CR9R10, Y is a carbonyl group or the radical ═CR9R10, R1 and R2 are identical or different electron-withdrawing radicals, chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl, optionally substituted aminocarbonyl, alkyl- or arylsulfinyl, alkyl- or arylsulfonyl and optionally substituted aminosulfonyl, R3 is a hydrogen atom, a cyano, hydroxyl, carboxyl or aminocarbonyl group or a C5-C20-aryl radical or C1-C20-alkylradical optionally bonded via an oxygen bridge, an aminocarbonyl bridge or oxycarbonyl bridge, R4 is a hydrogen atom, a hydroxyl group, an amino group, or a C5-C20-aryl radical or C1-C20-alkyl radical optionally bonded via an oxygen bridge, and R5 to R10 independently of one another are hydrogen or C1-C20-alkyl radicals and where in addition R7 and R8 together with the chain carbon atom are a carbonyl group, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin and human hair from solar rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.

    摘要翻译： 本发明涉及式Iin的化合物，其中X是氧的二价基团，羰基，任选地是脂族取代的亚氨基或基团= CR 9 R 10，Y是羰基或基团= CR 9 R 10，R 1和R 2是相同或不同的吸电子基团，选自氰基，烷基 - 或芳基羰基，烷氧基 - 或芳氧基羰基，任选取代的氨基羰基，烷基 - 或芳基亚磺酰基，烷基 - 或芳基磺酰基和任选取代的氨基磺酰基，R 3是氢原子，氰基，羟基，羧基或氨基羰基或C 5 -C 20 - 芳基或任选经氧连接的C 1 -C 20 - 烷基 桥，氨基羰基桥或氧羰基桥，R 4是氢原子，羟基，氨基或任选通过氧桥键合的C 5 -C 20 - 芳基或C 1 -C 20 - 烷基， R 5至R 10彼此独立地是氢或C 1 -C 20烷基，并且其中 R 7和R 8与链碳原子一起是羰基，作为用于保护人类皮肤和人类头发免受太阳光线影响的化妆品和药物制剂中的光稳定性UV过滤剂，单独或与在 UV区域，并且本身已知化妆品和药物制剂。

    Process for the preparation of 3-isochromanoes by cyclization of o-chloromethylphenylacetic acids
    6.
    发明授权
    Process for the preparation of 3-isochromanoes by cyclization of o-chloromethylphenylacetic acids 失效
    通过邻氯甲基苯基乙酸的环化制备3-异色烯的方法

    公开(公告)号：US06215006B1

    公开(公告)日：2001-04-10

    申请号：US09574332

    申请日：2000-05-19

    申请人： Holger Geissler

    发明人： Holger Geissler

    IPC分类号： C07D31174

    CPC分类号： C07D311/76

    摘要： The present invention relates to a process for the preparation of a 3-isochromanone of the formula (I) by reaction of an o-chloromethylphenylacetic acid of the formula (II) at a temperature of 100 to 250° C. in the presence or absence of an ionic halide, in the presence or absence of an organic solvent with and removal of hydrogen chloride, where in the formulae (I) and (II) the radicals R1, R2, R3 and R4 independently of one another are: a hydrogen or fluorine atom; an NC or F3C group; an alkyl alkoxy or acyloxy radical, each having 1 to 18 carbon atoms; or a C6-C18-aryloxy, aryl or heteroaryl radical, 1 to 3 atoms from the group consisting of O, N and/or S being present as heteroatoms; or in which at least two of the radicals R1, R2, R3 and R4 are linked to one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms.

    摘要翻译： 本发明涉及通过式（II）的邻氯甲基苯基乙酸在100-250℃的温度下，在存在或不存在下反应制备式（I）的3-异色满酮的方法 在存在或不存在有机溶剂和除去氯化氢的情况下，离子卤化物，其中在式（I）和（II）中，基团R 1，R 2，R 3和R 4彼此独立地是：氢或 氟原子; NC或F3C基团;烷基烷氧基或酰氧基，各自具有1至18个碳原子; 或C 1 -C 18芳氧基，芳基或杂芳基，其中1至3个原子来自O，N和/或S作为杂原子存在;或其中R1，R2，R3和R4中的至少两个 彼此连接并形成至少一个具有5至18个碳原子的脂族或芳族环。