公开(公告)号：US06730799B2

公开(公告)日：2004-05-04

申请号：US10162947

申请日：2002-06-05

申请人： Herbert Gayer ,  Bernd Gallenkamp ,  Peter Gerdes ,  Ulrich Heinemann ,  Bernd-Wieland Krüger ,  Reinhard Lantzsch ,  Thomas Seitz ,  Uwe Stelzer

发明人： Herbert Gayer ,  Bernd Gallenkamp ,  Peter Gerdes ,  Ulrich Heinemann ,  Bernd-Wieland Krüger ,  Reinhard Lantzsch ,  Thomas Seitz ,  Uwe Stelzer

IPC分类号： C07D30777

CPC分类号： C07D273/00 ,  C07D307/82 ,  C07D307/83 ,  C07D407/12

摘要： The present invention relates to a plurality of novel processes and novel intermediates for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines, which are known as intermediates for preparing compounds having fungicidal properties (WO 95-04728).

摘要翻译： 本发明涉及用于制备3-（1-羟基苯基-1-肟基甲基）二恶嗪的多种新方法和新型中间体，其被称为制备具有杀真菌性质的化合物的中间体（WO 95-04728）。

公开(公告)号：US06218552B1

公开(公告)日：2001-04-17

申请号：US08229671

申请日：1994-04-19

申请人： Junichi Sekihachi ,  Jun Yamamoto ,  Yasuyoshi Ueda

发明人： Junichi Sekihachi ,  Jun Yamamoto ,  Yasuyoshi Ueda

IPC分类号： C07D30777

CPC分类号： C09B67/0025 ,  C09B57/00 ,  Y10T428/2913 ,  Y10T428/2915

摘要： A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2&thgr;, of 4.7°, among peaks appearing within the range of not smaller than 3° of 2&thgr;, in an X-ray diffraction using a Cu-K&agr;-ray. The compound gives dyed or printed products having deep and brilliant tint of colors with excellent fastnesses, when applied to hydrophobic fiber materials, particularly, polyester fiber materials.

摘要翻译： 具有在衍射角呈现最强峰的结晶结构的化合物3-苯基-7- [4-（四氢呋喃氧基）苯基] -1,5-二氧杂-s-引丙烯-2,6-二酮， 在使用Cu-Kalpha射线的X射线衍射中，出现在不大于3θ的范围内的峰之间的4.7°的2θ。 当应用于疏水性纤维材料，特别是聚酯纤维材料时，该化合物产生具有优异坚牢度的深色和辉煌色彩的染色或印刷产品。

公开(公告)号：US06169181A

公开(公告)日：2001-01-02

申请号：US09188998

申请日：1998-11-09

申请人： Karen Rene Romines ,  Gordon L. Bundy ,  Theresa M. Schwartz ,  Ruben A. Tommasi ,  Joseph W. Strohbach ,  Steven Ronald Turner ,  Suvit Thaisrivongs ,  Paul Adrian Aristoff ,  Paul D. Johnson ,  Harvey Irving Skulnick ,  Louis L. Skaletzky ,  David John Anderson ,  Joel Morris ,  Ronald B. Gammill ,  George P. Luke

发明人： Karen Rene Romines ,  Gordon L. Bundy ,  Theresa M. Schwartz ,  Ruben A. Tommasi ,  Joseph W. Strohbach ,  Steven Ronald Turner ,  Suvit Thaisrivongs ,  Paul Adrian Aristoff ,  Paul D. Johnson ,  Harvey Irving Skulnick ,  Louis L. Skaletzky ,  David John Anderson ,  Joel Morris ,  Ronald B. Gammill ,  George P. Luke

IPC分类号： C07D30777

CPC分类号： C07D405/12 ,  C07D309/32 ,  C07D309/38 ,  C07D311/02 ,  C07D311/74 ,  C07D405/14

摘要： The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. wherein R10 and R20 taken together are:

摘要翻译： 本发明涉及式I和II的化合物，其为吡喃-2-酮，5,6-二氢 - 吡喃-2-酮，4-羟基 - 苯并吡喃-2-酮，4-羟基 - 环烷基[b]吡喃 -2-酮及其衍生物，其可用于抑制感染该逆转录病毒的哺乳动物细胞中的逆转录病毒。其中R10和R20一起为：

公开(公告)号：US06828347B2

公开(公告)日：2004-12-07

申请号：US10288685

申请日：2002-11-06

申请人： Kenneth William Stagliano ,  Ashkan Emadi

发明人： Kenneth William Stagliano ,  Ashkan Emadi

IPC分类号： C07D30777

CPC分类号： C07D311/92 ,  A61K31/12 ,  C07C46/00 ,  C07C50/08 ,  C07C50/24 ,  C07C50/30

摘要： This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of the first quinone and a second directing group at a C-3 of the first quinone and obtaining a biquinone having one of the first and second directing groups at a C-3 of a first quinone monomer and a hydroxyl group at a C-3′ of a second quinone monomer. The biquinone can be further reacted to obtain various biquinone derivatives or with a second hydroxyquinone anion to obtain trimeric quinone derivatives, including trimeric naphthoquinone derivatives. The biquinones and trimeric quinones of this invention demonstrate antiviral activity and can be used to treat viral infections, particularly HIV infections.

摘要翻译： 本发明提供了各种双醌和三聚醌衍生物。 本发明还提供了一种合成多醌化合物的方法，包括使羟基醌阴离子与第一醌的C-2上具有第一定向基团的第一醌反应，第二定向基团在第一个醌的C-3处 醌，得到在第一醌单体的C-3和第二醌单体的C-3'的羟基上具有第一和第二导向基团之一的双醌。 可以进一步反应该双醌以获得各种双醌衍生物或第二羟基醌阴离子，得到三聚醌衍生物，包括三聚萘醌衍生物。 本发明的双醌和三聚醌表现出抗病毒活性，可用于治疗病毒感染，特别是HIV感染。

公开(公告)号：US06476238B1

公开(公告)日：2002-11-05

申请号：US09855429

申请日：2001-05-16

申请人： Shiao-Jung Chu ,  Chien-Liang Hwang

发明人： Shiao-Jung Chu ,  Chien-Liang Hwang

IPC分类号： C07D30777

CPC分类号： C07D493/04 ,  C07C51/265 ,  C07C51/573 ,  C07D307/77 ,  C07C63/313

摘要： A purification method for obtaining high-purity PMDA. The method controls temperatures of cyclone separators in a series to separate PMDA and other by-products of different sublimation temperatures. High-purity PMDA is collected in the first cyclone separator, and no other purification steps are needed.

摘要翻译： 一种获得高纯度PMDA的纯化方法。 该方法控制一系列旋风分离器的温度，以分离PMDA和不同升华温度的其他副产物。 在第一旋风分离器中收集高纯度PMDA，不需要其他纯化步骤。

公开(公告)号：US06545167B1

公开(公告)日：2003-04-08

申请号：US10163502

申请日：2002-06-07

申请人： S. R. Moorty ,  A. Dilip Kumar

发明人： S. R. Moorty ,  A. Dilip Kumar

IPC分类号： C07D30777

CPC分类号： C07D307/93

摘要： Methods are disclosed for the large-scale isolation of 98.5% pure Nimbin from Neem seeds. The ultimate product is obtained first from an alcoholic extraction with subsequent partitioning using chlorinated hydrocarbon solvents. A resulting partitioned layer, which is recovered and concentrated, is then stripped with a hydrocarbon solvent, distilled and cooled to ambient temperature. The resulting mass is mixed and washed in a second hydrocarbon solvent, after which the resulting solid is washed in methanol and treated with activated carbon to produce a crystalline, tasteless product having a melting point of approximately 210-212° C.

摘要翻译： 公开了从Neem种子大规模分离98.5％纯Nimbin的方法。 最终产品首先从酒精提取中获得，随后使用氯化烃溶剂进行分配。 然后将得到的分离层回收和浓缩，然后用烃溶剂汽提，蒸馏并冷却至环境温度。 将所得物质混合并在第二烃溶剂中洗涤，之后将所得固体在甲醇中洗涤并用活性炭处理以产生熔点为约210-212℃的结晶无味产物。

公开(公告)号：US06492533B1

公开(公告)日：2002-12-10

申请号：US09955324

申请日：2001-09-18

申请人： Daniel M. Connor ,  Eric B. Stephens

发明人： Daniel M. Connor ,  Eric B. Stephens

IPC分类号： C07D30777

CPC分类号： C07D493/04 ,  C09B57/00 ,  C09B69/00

摘要： Colorants comprising a chromophore having two methine moieties attached to a benzodifuranone backbone, wherein said moieties optionally have at least one poly(oxyalkylene) chain, preferably at least two such chains attached thereto are provided. Such colorants exhibit excellent thermal stability, effective colorations, excellent low extraction rates, and effective lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain substrates, particularly polyesters. The optional poly(oxyalkylene) chains also increase the solubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or on diverse substrates as well as provides a liquid colorant which facilitates handling. Compositions and articles comprising such colorants are provided as are methods for producing such inventive colorants.

摘要翻译： 包含具有连接于苯并二呋喃酮骨架的两个次甲基部分的发色团的着色剂，其中所述部分任选地具有至少一个聚（氧化烯）链，优选至少两个附着于其上的链。 这些着色剂表现出优异的热稳定性，有效着色，优异的低萃取速率和有效的耐光性水平，特别是当结合到某些介质和/或某些基材，特别是聚酯的表面上时。 任选的聚（氧化烯）链还增加了在不同溶剂或树脂中的溶解度，从而允许在不同的介质和/或不同的基底中引入这些优异的着色发色团，并提供便于处理的液体着色剂。 作为制造这种着色剂的方法，提供了包含这种着色剂的组合物和制品。

公开(公告)号：US06452021B1

公开(公告)日：2002-09-17

申请号：US09963402

申请日：2001-09-27

申请人： Tsukasa Takahashi ,  Yasuhisa Emoto ,  Etsushige Matsunami

发明人： Tsukasa Takahashi ,  Yasuhisa Emoto ,  Etsushige Matsunami

IPC分类号： C07D30777

CPC分类号： C07C51/235 ,  C07C63/307

摘要： The present invention has for its object to provide a production method of pyromellitic anhydride of high purity in good yield at low cost by catalytic gas-phase oxidation of a 2,4,5-trialkylbenzaldehyde with the aid of a suitable catalyst system. The present invention relates to a production method of pyromellitic anhydride comprising a step for catalytic gas-phase oxidation of a 2,4,5-trialkylbenzaldehyde with a molecular oxygen-containing gas in which said step for catalytic gas-phase oxidation is carried out in the presence of a catalyst such that a specific surface area of the catalytic active component thereof is not greater than 50 m2/g or in the presence of a catalyst containing vanadium as well as molybdenum and/or tungsten as a catalytic active component.

摘要翻译： 本发明的目的是通过合适的催化剂体系，通过2,4,5-三烷基苯甲醛的催化气相氧化，以低成本提供高纯度的均苯四酸酐的制备方法。 本发明涉及1,2,4,5-苯四酸酐的制备方法，其包括用含有分子氧的气体催化气相氧化2,4,5-三烷基苯甲醛的步骤，其中所述催化气相氧化步骤在存在下进行 的催化剂，使得其催化活性组分的比表面积不大于50m 2 / g，或者在含有钒的催化剂以及钼和/或钨作为催化活性组分的存在下。

公开(公告)号：US06441198B1

公开(公告)日：2002-08-27

申请号：US09747499

申请日：2000-12-22

申请人： Ahmed Kamal ,  Laxman Eltepu ,  Arifuddin Mohammed ,  Gollapalli Bhasker Ramesh Khanna

发明人： Ahmed Kamal ,  Laxman Eltepu ,  Arifuddin Mohammed ,  Gollapalli Bhasker Ramesh Khanna

IPC分类号： C07D30777

CPC分类号： C07D493/04

摘要： The present invention discloses novel podophyllotoxin dimers having structural formula I wherein R is H or CH3 and Z is aryl or subsituted aryl compound selected form the group counting of phenylene, naphthalene, p-terpbhnyl, dimethoxy benzidine and diphenyl ether and a process for the preparation of said novel podophyllotoxin dimers. The new podophyllotoxin dimers, pawculaty 4-arylamino derivatives of the podophyllotoxin dimers of the present invention as useful as potent inhibitors of DNA-topoisomerase II and are also useful as antitumour agents.

摘要翻译： 本发明公开了具有结构式I的新型鬼臼毒素二聚体，其中R是H或CH 3，Z是选自亚苯基，萘基，对叔丁基，二甲氧基联苯胺和二苯基醚的芳基或取代的芳基化合物，以及制备 说小说鬼臼毒二聚体。 新的鬼臼毒素二聚体，本发明的鬼臼毒素二聚体的棘爪4-芳基氨基衍生物可用作DNA拓扑异构酶II的有效抑制剂，并且也可用作抗肿瘤剂。