公开(公告)号：US06545167B1

公开(公告)日：2003-04-08

申请号：US10163502

申请日：2002-06-07

申请人： S. R. Moorty ,  A. Dilip Kumar

发明人： S. R. Moorty ,  A. Dilip Kumar

IPC分类号： C07D30777

CPC分类号： C07D307/93

摘要： Methods are disclosed for the large-scale isolation of 98.5% pure Nimbin from Neem seeds. The ultimate product is obtained first from an alcoholic extraction with subsequent partitioning using chlorinated hydrocarbon solvents. A resulting partitioned layer, which is recovered and concentrated, is then stripped with a hydrocarbon solvent, distilled and cooled to ambient temperature. The resulting mass is mixed and washed in a second hydrocarbon solvent, after which the resulting solid is washed in methanol and treated with activated carbon to produce a crystalline, tasteless product having a melting point of approximately 210-212° C.

摘要翻译： 公开了从Neem种子大规模分离98.5％纯Nimbin的方法。 最终产品首先从酒精提取中获得，随后使用氯化烃溶剂进行分配。 然后将得到的分离层回收和浓缩，然后用烃溶剂汽提，蒸馏并冷却至环境温度。 将所得物质混合并在第二烃溶剂中洗涤，之后将所得固体在甲醇中洗涤并用活性炭处理以产生熔点为约210-212℃的结晶无味产物。