公开(公告)号：US06268530B1

公开(公告)日：2001-07-31

申请号：US09030281

申请日：1998-01-05

申请人： Imre Toth ,  Onko Gelling ,  Rudolf P. M. Guit ,  Antonius J. F. Simons ,  Simon Hans H. Niemann

发明人： Imre Toth ,  Onko Gelling ,  Rudolf P. M. Guit ,  Antonius J. F. Simons ,  Simon Hans H. Niemann

IPC分类号： C07C59147

CPC分类号： C07D221/08 ,  C07C51/48 ,  C07C59/147

摘要： Process to separate linear 5-formylvaleric acid from a mixture of 5- and 3- and 4-formylvaleric acids, wherein the separation is performed by fractional extraction with two immiscible solvents of which one solvent is an aqueous solvent and the other solvent is an organic solvent, in which the organic solvent has a higher or lower affinity for 5-formylvaleric acid than its affinity for the 3-formylvaleric acids and for the 4-formylvaleric acid. Furthermore the invention relates to an improved process to prepare ∈-caprolactam starting from a mixture of branched and linear formylvaleric acids or starting from pentenoic acid.

摘要翻译： 从5-和3-甲酰基戊酸的混合物中分离线性5-甲酰戊酸的方法，其中分离通过两种不混溶的溶剂进行分离，其中一种溶剂是一种溶剂，另一种溶剂是有机溶剂 溶剂，其中有机溶剂对5-甲酰基戊酸的亲和力高于或低于其对3-甲酰基戊酸和4-甲酰基戊酸的亲和力。 此外，本发明涉及从支链和直链甲酰基戊酸的混合物开始或从戊烯酸开始制备ε-己内酰胺的改进方法。

公开(公告)号：US06342631B1

公开(公告)日：2002-01-29

申请号：US09651638

申请日：2000-08-30

申请人： Ivo Pischel ,  Stefan Weiss ,  Gunter Ortenburger ,  Harro Konig

发明人： Ivo Pischel ,  Stefan Weiss ,  Gunter Ortenburger ,  Harro Konig

IPC分类号： C07C59147

CPC分类号： C07C59/19 ,  A23L33/165 ,  C07C51/412

摘要： A method of producing calcium pyruvates is described, in which calcium salts of organic acids or acidic organic keto or hydroxy compounds are reacted with pyruvic acid at a temperature in the range from −20 to +120° C., if necessary in the presence of a solvent or diluent. In this way, high-purity calcium pyruvates are obtained which can be largely free of water and have a very long shelf life.

摘要翻译： 描述了产生丙酮酸钙的方法，其中有机酸的钙盐或酸性有机酮或羟基化合物与丙酮酸在-20至+ 120℃的温度下反应，如有必要，在存在 溶剂或稀释剂。 以这种方式，可以获得高纯度的丙酮酸钙，其可以大部分不含水并且具有非常长的保存期限。

公开(公告)号：US06492550B2

公开(公告)日：2002-12-10

申请号：US09779411

申请日：2001-02-08

申请人： Jacques Banville ,  Serge Plamondon ,  Yonghua Gai ,  Neelakantan Balasubramanian

发明人： Jacques Banville ,  Serge Plamondon ,  Yonghua Gai ,  Neelakantan Balasubramanian

IPC分类号： C07C59147

CPC分类号： A61K31/216 ,  A61K31/255 ,  A61K31/662

摘要： Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.

摘要翻译： 提供胞质磷酸酯酶A2酶的抑制剂，其可用于控制各种炎性疾病。 本发明的抑制剂具有通式，X，Z，X 1，R 1，R 2，R a和R b如本说明书中所定义。

公开(公告)号：US06833475B2

公开(公告)日：2004-12-21

申请号：US10449098

申请日：2003-06-02

申请人： Arun Kumar Sinha ,  Bhupendra Prasad Joshi ,  Ruchi Dogra

发明人： Arun Kumar Sinha ,  Bhupendra Prasad Joshi ,  Ruchi Dogra

IPC分类号： C07C59147

CPC分类号： C07C51/29 ,  C07C59/347

摘要： A natural inexpensive acyclic monoterpene ketone (dihydrotagetone) of formula (4), isolated from the oil of Tagetes sp., was smoothly oxidized with meta-periodate/potassium permanganate into 2,6-dimethyl-4-oxo-heptanoic acid of formula (3), the reduction of 3 with metal hydride such as sodium borohydride or lithium aluminium hydride provided 4-hydroxyacid of formula (2) which on without isolation undergone lactonisation in acidic medium furnished two chiral centered 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone of formula (1) as an analogue of whisky lactone 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1a) responsible for high quality of alcoholic beverage (whisky, wine, brandy and scotch), in addition, coconut flavoured 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1) is also as an analogue of coconut aldehyde (&ggr;-nonalactone, F.E.M.A. No. 2751) of formula (1b) which is responsible for flavouring a wide range of food stuffs including baked goods and confectionery.

摘要翻译： 从Tagetes sp。油中分离得到的式（4）的天然廉价的无环单萜酮（二氢t酮）用高碘酸钾/高锰酸钾被平滑地氧化成式（4）的2,6-二甲基-4-氧代 - 庚酸 3）中，用金属氢化物如硼氢化钠或氢化铝锂还原3，得到式（2）的4-羟基酸，其在酸性介质中经过内酯化而没有分离，提供了两个手性中心的5-异丁基-3-甲基-4- （1）的5-二氢-2（3H） - 呋喃酮作为负责高品质的式（1a）的威士忌内酯5-丁基-4-甲基-4,5-二氢-2（3H） - 呋喃酮的类似物 的酒精饮料（威士忌，葡萄酒，白兰地和苏格兰威士忌），此外，式（1）的椰子风味的5-丁基-4-甲基-4,5-二氢-2（3H） - 呋喃酮也是椰子的类似物 式（1b）的醛（γ-非内酯，FEMA No.2751），其负责调味各种食品，包括烘焙食品和糖果 ery。

公开(公告)号：US06177578B1

公开(公告)日：2001-01-23

申请号：US09035607

申请日：1998-03-05

申请人： David F. Lewis ,  Sangya S. Varma

发明人： David F. Lewis ,  Sangya S. Varma

IPC分类号： C07C59147

CPC分类号： C07C57/24 ,  C07C57/18 ,  G03C1/73 ,  G03F7/025

摘要： This invention relates to a mixture of imageable polyacetylenic compounds which have similar photosensitivities and which are visually imageable in complementary colors combinable to provide a black image, which mixture contains at least one polyacetylenic metal salt which produces a color, preferably a metal salt of a diacetylene C6 to C48 mono- or dicarboxylic acid, which is complementary to a color produced by another polyacetylenic metal salt or non-metallic polyacetylenic compound contained in the mixture or in an another integral color forming layer. The invention also pertains to the use of said mixture and the manner of its preparation.

摘要翻译： 本发明涉及可成像的聚乙炔化合物的混合物，其具有相似的光敏性，并且可以互补的可视形态地形成可组合以提供黑色图像的混合物，该混合物含有至少一种产生颜色的聚乙炔性金属盐，优选为乙炔的金属盐 C6至C48单羧酸或二羧酸，其与由混合物中所含的另一种聚乙炔性金属盐或非金属聚乙炔化合物或另一整体成色层产生的颜色互补。 本发明还涉及所述混合物的用途及其制备方法。