公开(公告)号：US06413429B1

公开(公告)日：2002-07-02

申请号：US09754159

申请日：2001-01-04

申请人： Berthold Berend Breman ,  Jan Visser

发明人： Berthold Berend Breman ,  Jan Visser

IPC分类号： B02D1100

CPC分类号： B01D11/0449 ,  B01D11/0457 ,  Y10S210/05

摘要： Claimed are a process and an apparatus for extracting a component dissolved in a liquid by means of liquid-liquid extraction using an extraction liquid which is immiscible or only partially miscible with the liquid, in which process the extraction liquid is dispersed in the liquid in a dispersion apparatus and then coalesced in a coalescer, after which the ex traction liquid, the specific weight of which differs by at least 5% from the specific weight of the liquid to be extracted in which the component to be extracted is to be found, is separated from the liquid by gravity in a phase separator in which process in order to obtain an efficiency per extraction stage of at least 0.9 at an average residence time of at most 15 seconds in the dispersion apparatus and of at most 300 seconds in the phase separator, at a linear velocity in the coalescer related to its cross-section of at least 30 m/hour: a. the dispersion apparatus used is a centrifugal pump which will give droplets having an average diameter of 5 to 500 &mgr;m, b. the coalescer used is a packed bed of 5-100 cm high composed of dimensionally stable particles wettable by the extraction liquid having an average particle size of 0.05 to 2 mmL and c. the coagulated phase in the phase separator is separated at a linear velocity related to the cross-section of the phase separator of 0.1 to 0.7 times the linear velocity in the coalescer.

摘要翻译： 本发明提供了一种通过使用与液体不混溶或仅部分混溶的萃取液的液 - 液萃取来提取溶解在液体中的组分的方法和装置，在该方法中，萃取液在液体中分散在液体中 分散装置，然后在聚结器中聚结，之后其比重与要提取的组分的待提取液体的比重相差至少5％的前牵引液体为 在相分离器中通过重力与液体分离，其中在分散装置中，为了在分散装置中平均停留时间至多为15秒，并且在相分离器中至多300秒，每个萃取阶段获得至少0.9的效率 在与聚结器相关的线速度至少为30m /小时的横截面上：a。 使用的分散装置是一种离心泵，其将产生平均直径为5至500μm的液滴，b。 所使用的聚结器是由平均粒径为0.05-2mmL的萃取液可湿化的尺寸稳定的颗粒组成的5-100cm高的填充床。 相分离器中的凝固相以与分离器的横截面相关的线速度分离成聚结器中的线速度的0.1至0.7倍。

公开(公告)号：US06454945B1

公开(公告)日：2002-09-24

申请号：US09703764

申请日：2000-11-01

申请人： Bernhard H. Weigl ,  Paul Yager ,  James P. Brody ,  Mark R. Holl ,  Fred K. Forster ,  Eric Altendorf ,  Paul C. Galambos ,  Margaret Kenny ,  David Schutte ,  Gregory Hixson ,  Diane Zebert ,  Andrew Kamholz ,  Caicai Wu

发明人： Bernhard H. Weigl ,  Paul Yager ,  James P. Brody ,  Mark R. Holl ,  Fred K. Forster ,  Eric Altendorf ,  Paul C. Galambos ,  Margaret Kenny ,  David Schutte ,  Gregory Hixson ,  Diane Zebert ,  Andrew Kamholz ,  Caicai Wu

IPC分类号： B02D1100

CPC分类号： B01D11/0492 ,  A61M1/14 ,  B01D11/0496 ,  B01L3/5027 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  G01N15/1484 ,  Y10T436/25375

摘要： This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers. Such diffusion-based mixing or sensing devices are preferably channel cell systems for detecting the presence and/or measuring the quantity of analyte particles in a sample stream.

摘要翻译： 本发明提供了用于从含有所需和不需要的颗粒的样品流中提取所需颗粒的微制造系统。 在惯性效应可忽略的条件下，将样品流与提取流层流接触。 保持两个物流之间的接触足够的时间，以便将期望的颗粒从样品流中差分输送到萃取物流中。 在优选实施例中，差分传送机构是扩散。 本发明的提取系统耦合到基于微制造的基于扩散的混合装置和/或感测装置允许在不大于硅晶片的装置上处理或分析皮升数量的流体。 这种基于扩散的混合或感测装置优选是用于检测样品流中分析物颗粒的存在和/或测量量的通道电池系统。