知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

41 条记录 (耗时 0.033 秒)

    Antibacterial aqueous ophthalmic formulations containing ofloxacin and use of chitosan for solubilizing ofloxacin suspended in an aqueous media
    2.
    发明申请
    Antibacterial aqueous ophthalmic formulations containing ofloxacin and use of chitosan for solubilizing ofloxacin suspended in an aqueous media 有权
    含有氧氟沙星的抗菌水性眼用制剂和使用壳聚糖增溶悬浮在水性介质中的氧氟沙星

    公开(公告)号：US20020002148A1

    公开(公告)日：2002-01-03

    申请号：US09859908

    申请日：2001-05-17

    发明人： Robert Gurny ,  Olivia Mireille Felt

    IPC分类号： A61K031/495 ,  A61K031/722

    CPC分类号： A61K9/0048 ,  A61K47/36

    摘要： The aqueous ophthalmic formulation for the treatment and prevention of infections contains ofloxacin as active ingredient and a chitosan having a weight average molecular weight of 500,000-5,000,000 Daltons and a deacetylation degree of 30-90% as solubilizing agent of ofloxacin. Chitosan having a deacetylation degree of 30-90% may be also used for solubilizing ofloxacin suspended in an aqueous media having a substantially neutral pH in any other applications.

    摘要翻译： 用于治疗和预防感染的水性眼用制剂含有氧氟沙星作为活性成分，重均分子量为500,000-5,000,000道尔顿，脱乙酰度为30-90％的脱乙酰壳多糖作为氧氟沙星的增溶剂。 脱乙酰度为30-90％的脱乙酰壳多糖也可用于溶解悬浮在任何其它应用中具有基本上中性pH的水性介质中的氧氟沙星。

    METHODS AND KITS FOR ABSORBING FAT
    4.
    发明申请
    METHODS AND KITS FOR ABSORBING FAT 审中-公开
    吸收脂肪的方法和工具

    公开(公告)号：US20030069206A1

    公开(公告)日：2003-04-10

    申请号：US09474695

    申请日：1999-12-29

    发明人： Everett J. Nichols

    IPC分类号： A61K031/722

    CPC分类号： C08B37/003 ,  A23L29/275 ,  A61K47/61 ,  A61K47/69 ,  C08L5/08

    摘要： In one aspect, the present invention provides kits for reducing absorption of lipids by the gastrointestinal tract of a mammalian body. The kits include chitosan, packaging, and instructions indicating that the chitosan may be consumed with food. Chitosan useful for incorporation into kits of the present invention dissolves sufficiently rapidly in gastric juice that it does not have to be consumed in advance of a meal in order to dissolve within the stomach and thereafter effectively entrap lipids in the gastrointestinal tract of the consumer. In a particular embodiment of the kits of the present invention, the chitosan possesses the property of dissolving in a 100-fold (w/w) excess of 0.16N hydrochloric acid, at a temperature in the range of from 16null C. to 25null C., so that the maximum viscosity of the dissolved chitosan solution is reached within 5 minutes after the acid contacts the chitosan. It is desirable to utilize chitosan having a high tap density and/or high bulk density in the kits of the present invention. In another aspect, the present invention provides methods for reducing absorption of lipids by the gastrointestinal tract of a mammalian body. The methods include the step of providing a consumer with a kit including chitosan, packaging, and instructions indicating that the chitosan may be consumed with food. The kits of the present invention are useful in the practice of the methods of the present invention. By utilizing the kits and/or methods for lipid absorption reduction of the present invention a consumer does not have to remember to consume lipid-absorbing chitosan in advance of food consumption.

    摘要翻译： 一方面，本发明提供了用于减少哺乳动物体的胃肠道吸收脂质的试剂盒。 试剂盒包括壳聚糖，包装和说明，表明壳聚糖可能与食物一起食用。 用于掺入本发明试剂盒中的壳聚糖在胃液中足够快地溶解，其不必在饭前提前消费，以便在胃中溶解，然后有效地将脂质捕获到消费者的胃肠道中。 在本发明的试剂盒的一个具体实施方案中，壳聚糖具有在16℃至25℃的温度范围内溶解于100倍（w / w）过量的0.16N盐酸中的性质 ℃，使得在酸接触壳聚糖后5分钟内达到溶解的壳聚糖溶液的最大粘度。 希望在本发明的试剂盒中使用具有高振实密度和/或高堆积密度的壳聚糖。 另一方面，本发明提供了减少哺乳动物体的胃肠道吸收脂质的方法。 所述方法包括向消费者提供包括壳聚糖，包装和说明壳聚糖可能被食物消耗的说明书的步骤。 本发明的试剂盒可用于实施本发明的方法。 通过利用本发明的用于减少脂质吸收的试剂盒和/或方法，消费者不必记住在食物消耗之前消耗脂质吸收壳聚糖。

    Method of skin care
    5.
    发明申请
    Method of skin care 失效
    护肤方法

    公开(公告)号：US20030022842A1

    公开(公告)日：2003-01-30

    申请号：US10076686

    申请日：2002-02-14

    申请人： YAIZU SUISANKAGAKU INDUSTRY CO., LTD.

    发明人： Yoshiharu Matahira ,  Michiko Saito ,  Nobuyuki Sugita

    IPC分类号： A61K038/39 ,  A61K031/722

    CPC分类号： A61Q19/00 ,  A61B2017/22038 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/124 ,  A61B2018/1435 ,  A61K8/02 ,  A61K8/60 ,  A61K8/65 ,  A61K8/673 ,  A61K8/676 ,  A61K8/68 ,  A61K8/735 ,  A61K2800/92 ,  A61Q19/08 ,  Y10S514/878

    摘要： The present invention provides a method for skin care by orally administering a skin care agent comprising an ingestible carrier and natural-type N-acetylglucosamine obtainable by hydrolysis of chitin with an acid, an enzyme, or an acid and an enzyme, wherein the natural-type N-acetylglucosamine is contained in an amount of from 0.1 to 99.9% by weight, by which the moisture and tension of skin can be improved and the rough skin and fine wrinkles can be prevented or ameliorated. The skin care agent may be a skin care agent containing chitinoligosaccharide in an amount of from 0.1 to 20% by weight and natural-type N-acetylglucosamine in an amount of from 0.1 to 99.9% by weight; or a skin care agent containing collagen peptide in an amount of from 0.1 to 99.9% by weight and natural-type N-acetylglucosamine in an amount of from 0.1 to 99.9% by weight.

    摘要翻译： 本发明提供了一种通过口服给予皮肤护理剂的方法，所述护肤剂包含可通过用酸，酶或酸和酶水解壳多糖获得的可摄取载体和天然型N-乙酰葡糖胺，其中所述天然 - N-乙酰氨基葡糖胺的含量为0.1〜99.9重量％，能够改善皮肤的水分和张力，可以防止或改善粗糙的皮肤和细小的皱纹。 皮肤护理剂可以是含有0.1至20重量％的几丁质量的外用护肤剂和0.1至99.9重量％的天然型N-乙酰葡糖胺; 或含有0.1〜99.9重量％的胶原肽的护肤剂和0.1〜99.9重量％的天然型N-乙酰葡糖胺。

    Prophylactic teat treatment
    7.
    发明申请
    Prophylactic teat treatment 审中-公开
    预防性乳头治疗

    公开(公告)号：US20020119949A1

    公开(公告)日：2002-08-29

    申请号：US09791739

    申请日：2001-02-26

    发明人： Asa Hellman ,  Torbjorn Mathisen

    IPC分类号： A61K031/721 ,  A61K031/722 ,  A61K031/727

    CPC分类号： A61K47/36 ,  A61K9/0014 ,  A61K31/721 ,  A61K31/722 ,  A61K31/727 ,  A61K47/10 ,  A61K47/12

    摘要： An aqueous solution for prophylactic treatment of teats of lactating mammals, comprising as a first component at least partially deacetylated chitosan, or an acid addition salt thereof, in a concentration of up to about 2% by weight of chitosan, the solution having a pH of from about 4 to about 6.8, and said first component having a molecular weight such that the viscosity of the solution is less than about 50 mPas; and a method of prophylactic treatment of teats of lactating mammals.

    摘要翻译： 一种用于预防哺乳哺乳动物乳头的水溶液，其包含至少部分至少部分去乙酰化壳聚糖或其酸加成盐的浓度为至多约2重量％的壳聚糖的第一组分，所述溶液的pH为 约4至约6.8，并且所述第一组分具有使得溶液的粘度小于约50mPa·s的分子量; 以及哺乳哺乳动物乳头的预防性治疗方法。

    Method for restoring a fat-pad
    8.
    发明申请
    Method for restoring a fat-pad 失效
    恢复脂肪垫的方法

    公开(公告)号：US20020094959A1

    公开(公告)日：2002-07-18

    申请号：US10055493

    申请日：2001-10-29

    发明人： Eric Andre DesRosiers

    IPC分类号： A61K038/39 ,  A61K031/715 ,  A61K031/722 ,  A61K031/728

    CPC分类号： A61K9/0024 ,  A61K31/20 ,  A61K31/201 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/50

    摘要： The present invention relates to a method for treating damaged or degenerated fat pads in a foot of a host in need thereof. The method comprises the step of injecting into the fat pad of the host a biocompatiable solution having physico-chemical and mechanical properties substantially similar to a fatty acid mixture normally present in a healthy fat pad.

    摘要翻译： 本发明涉及一种用于治疗有需要的宿主的受损或退化的脂肪垫的方法。 该方法包括将具有与通常存在于健康脂肪垫中的脂肪酸混合物基本相似的物理化学和机械性能的生物相容性溶液注入宿主的脂肪垫中的步骤。

    Salts of glutathione
    9.
    发明申请
    Salts of glutathione 审中-公开
    谷胱甘肽盐

    公开(公告)号：US20020002136A1

    公开(公告)日：2002-01-03

    申请号：US09893762

    申请日：2001-06-27

    发明人： Rolland F. Hebert

    IPC分类号： A61K038/06 ,  A61K031/722

    CPC分类号： A61K38/063

    摘要： Stable salts of glutathione with polycations such as chitosan are described. The salts according to the invention are valuable for use as active constituents in pharmaceutical as well as cosmeceutical compositions.

    摘要翻译： 描述了谷胱甘肽与聚阳离子如壳聚糖的稳定盐。 根据本发明的盐对于用作药物和药妆组合物中的活性成分是有价值的。

    Application of nanoparticles based on hydrophilic polymers as pharamaceutical forms
    10.
    发明申请
    Application of nanoparticles based on hydrophilic polymers as pharamaceutical forms 失效
    基于亲水聚合物的纳米颗粒作为药物形式的应用

    公开(公告)号：US20010051189A1

    公开(公告)日：2001-12-13

    申请号：US09908372

    申请日：2001-07-18

    申请人： Universidade de Santiago de Compostela

    发明人： Maria J. Alonso Fernandez ,  Pilar Calvo Salve ,  Carmen Remunan Lopez ,  Jose L. Vila Jato

    IPC分类号： A61K033/42 ,  A61K031/722

    CPC分类号： A61K9/5161

    摘要： Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms for the administration of active macromolecules. The nanoparticles (having a nanometric size and a hydrophilic character), also called nanospheres or latex, are colloidal systems comprised of the combination of hydrophilic polymers and an active ingredient having a high molecular weight (active macromolecule, molecular weight higher than 1000 daltons). The hydrophilic polymers are the chitosan (an aminopolysaccharide) or its derivatives and polyoxyethylene or its derivatives. The association of the active macromolecule to said nanoparticles takes place in an aqueous phase without having to use organic solvents or auxiliary toxic substances. The active ingredient charge capacity of the nanoparticles is extremely high and additionally said charge is released in a controlled and time extended way. Additionally, said nanoparticles have a positive surface electric charge whose intensity may vary in relation to its composition.

    摘要翻译： 基于亲水性聚合物的纳米颗粒的应用作为用于施用活性大分子的药物形式。 纳米颗粒（具有纳米尺寸和亲水特性）也称为纳米球或胶乳，是由亲水聚合物和具有高分子量（活性大分子，分子量高于1000道尔顿）的活性成分的组合组成的胶体体系。 亲水性聚合物是壳聚糖（氨基多糖）或其衍生物和聚氧乙烯或其衍生物。 活性大分子与所述纳米颗粒的结合在水相中进行，而不必使用有机溶剂或辅助有毒物质。 纳米颗粒的活性成分电荷容量非常高，另外所述电荷以受控和时间延长的方式释放。 另外，所述纳米颗粒具有正的表面电荷，其强度可以相对于其组成而变化。