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    Nanostructured separation and analysis devices for biological membranes
    2.
    发明申请
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：US20030102263A1

    公开(公告)日：2003-06-05

    申请号：US10338654

    申请日：2003-01-09

    Inventor： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC: B01D061/14

    CPC classification number: G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    Abstract translation: 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanostructured separation and analysis devices for biological membranes
    4.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42249E1

    公开(公告)日：2011-03-29

    申请号：US12217114

    申请日：2008-07-01

    Applicant: Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    Inventor： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC: B01D21/00

    CPC classification number: G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: The present invention provides a nonostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the subtrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures. A fluidic device for separating particles according to size is provided including a fluidic channel, and a matrix comprising a plurality of protrusions within the fluidic channel, wherein the device provides a driving force to the particles being separated through the fluidic channel; and wherein a flow of the driving force from between the protrusions is divided unequally into a major flow component and a minor flow component, each component flowing between subsequent protrusions in the matrix, such that the average direction of the major flow component is not parallel to the average direction of the driving force, and, when particles are introduced into the matrix, particles having a size less than a predetermined critical size are transported generally in the average direction of the driving force, and particles having a size at least that of the critical size are transported generally in the average direction of the major flow component, thereby separating the particles according to size. Methods for separating particles including steps of separation based on size and affinity are also provided.

    Abstract translation: 本发明提供一种非结构化装置，其包括其中包括纳入通道的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述缓冲液包含纳米结构，并且其中所述脂质双层包含至少一个膜相关的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。 提供了一种用于根据尺寸分离颗粒的流体装置，包括流体通道和在流体通道内包括多个突起的基体，其中该装置为通过流体通道分离的颗粒提供驱动力; 并且其中来自所述突起之间的驱动力的流动不均匀地分成主流动分量和小流动分量，每个分量在所述基体中的后续突起之间流动，使得主流动分量的平均方向不平行于 驱动力的平均方向，并且当颗粒被引入到基质中时，尺寸小于预定临界尺寸的颗粒通常沿驱动力的平均方向传送，并且尺寸至少大于 临界尺寸通常沿主流体组分的平均方向输送，从而根据尺寸分离颗粒。 还提供了基于尺寸和亲和力分离包括分离步骤的颗粒的方法。

    Nanostructured separation and analysis devices for biological membranes
    7.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE41762E1

    公开(公告)日：2010-09-28

    申请号：US12215893

    申请日：2008-06-30

    Applicant: Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    Inventor： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC: C02F1/00

    CPC classification number: G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    Abstract translation: 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanoparticle formulations of platinum compounds
    10.
    发明授权
    Nanoparticle formulations of platinum compounds 失效
    铂化合物的纳米颗粒配方

    公开(公告)号：US07611733B2

    公开(公告)日：2009-11-03

    申请号：US10594003

    申请日：2005-03-24

    Applicant: Maria Rosa Gasco ,  Paolo Gasco ,  Alberto Bernareggi

    Inventor： Maria Rosa Gasco ,  Paolo Gasco ,  Alberto Bernareggi

    IPC: A61K9/26 ,  A61K31/28 ,  C07F15/00

    CPC classification number: A61K9/5123 ,  Y10S977/717 ,  Y10S977/911

    Abstract: Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5° C. to 4° C. obtaining a dispersion of solid lipid microspheres; e) washing with aqueous medium through ultrafiltration the obtained lipid microspheres obtained in d) and lyophilizing, optionally in the presence of a bulking agent and of a cryoprotecting agent.

    Abstract translation: 公开了铂化合物，特别是抗肿瘤铂络合物的固体脂质纳米颗粒。 本发明的纳米颗粒通过以下方法获得：a）通过混合熔融脂质，表面活性剂和任选的助表面活性剂和铂化合物水溶液来制备第一微乳液; b）通过将表面活性剂和任选的辅助表面活性剂混合在水中，加热至完全溶液，优选在a）中使用的脂质的相同熔融温度并加入助表面活性剂来制备溶液; c）将a）中得到的微乳液分散在b）中得到的溶液中，得到多重微乳液c）; d）在0.5℃至4℃的温度范围内将c）中得到的微乳液分散在水性介质中，得到固体脂质微球的分散体; e）通过超滤所得到的在d）中获得的脂质微球，并用任选地在填充剂和冷冻保护剂的存在下进行冻干，用水性介质洗涤。

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