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1.发明申请公开(公告)号：US20170247705A1
公开(公告)日：2017-08-31
申请号：US15468157
申请日：2017-03-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DIDEROT - PARIS 7 , UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/3231 , C12N2310/3233 , C12N2320/33 , C12N2320/34 , C12Y499/01001
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of Erythropoietic Protoporphyria. In particular, the present invention relates to a method for increasing the amount of functional FECH in a erythroid cell carrying the hypomorphic allele IVS3 48C/T (rs2272783) in trans to a deleterious mutation in the FECH gene comprising the step of consisting of bringing the erythroid cell into contact with at least one antisense oligonucleotide (ASO) comprising the sequence as set forth by SEQ ID NO: 2 (5′ gcagcctgagaaatgtttt 3′) to prevent splicing of the cryptic exon inserted into the mutant IVS3 48C/T (rs2272783) FECH mRNA.
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2.发明申请公开(公告)号：US20150284739A1
公开(公告)日：2015-10-08
申请号：US14658600
申请日：2015-03-16
发明人： Stephen M Allen , Sobhana Sivasankar , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Scott V. Tingey , Robert Wayne Williams
IPC分类号： C12N15/82
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
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3.发明授权公开(公告)号：US09873877B2
公开(公告)日：2018-01-23
申请号：US15468157
申请日：2017-03-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DIDEROT—PARIS 7 , UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/3231 , C12N2310/3233 , C12N2320/33 , C12N2320/34 , C12Y499/01001
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of Erythropoietic Protoporphyria. In particular, the present invention relates to a method for increasing the amount of functional FECH in a erythroid cell carrying the hypomorphic allele IVS3 48C/T (rs2272783) in trans to a deleterious mutation in the FECH gene comprising the step of consisting of bringing the erythroid cell into contact with at least one antisense oligonucleotide (ASO) comprising the sequence as set forth by SEQ ID NO: 2 (5′ gcagcctgagaaatgtttt 3′) to prevent splicing of the cryptic exon inserted into the mutant IVS3 48C/T (rs2272783) FECH mRNA.
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4.发明申请DROUGHT TOLERANT PLANTS AND RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING FERROCHELATASES 审中-公开耐旱植物及相关构成及相关方法涉及编码鱼类的基因公开(公告)号：US20120180159A1
公开(公告)日：2012-07-12
申请号：US13430732
申请日：2012-03-27
申请人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
发明人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
摘要翻译： 用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。 重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码铁螯合酶。
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5.发明申请公开(公告)号：US20110010798A1
公开(公告)日：2011-01-13
申请号：US12887724
申请日：2010-09-22
申请人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
发明人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
IPC分类号： A01H1/06 , C12Q1/68 , C12N5/10 , C12N1/21 , C12N1/19 , C12N15/63 , C07H21/00 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
摘要翻译： 用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。 重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码铁螯合酶。
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6.发明授权Drought tolerant plants and related constructs and methods involving genes encoding ferrochelatases 有权耐旱植物和涉及编码铁螯合酶基因的相关构建体和方法公开(公告)号：US08993847B2
公开(公告)日：2015-03-31
申请号：US13430732
申请日：2012-03-27
申请人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
发明人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
摘要翻译： 用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。 重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码铁螯合酶。
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7.发明授权Drought tolerant plants and related constructs and methods involving gene encoding ferrochelatases 有权耐旱植物和涉及基因编码铁螯合酶的相关构建体和方法公开(公告)号：US08158859B2
公开(公告)日：2012-04-17
申请号：US12887724
申请日：2010-09-22
申请人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
发明人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
摘要翻译： 用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。 重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码铁螯合酶。
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8.发明授权Drought tolerant plants and related constructs and methods involving genes encoding ferrochelatases 有权耐旱植物和涉及编码铁螯合酶基因的相关构建体和方法公开(公告)号：US07812223B2
公开(公告)日：2010-10-12
申请号：US12326206
申请日：2008-12-02
申请人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
发明人： Stephen M. Allen , Stanley Luck , Jeffrey Mullen , Hajime Sakai , Sobhana Sivasankar , Scott V. Tingey , Robert Wayne Williams
CPC分类号： C12N15/8273 , C12N9/88 , C12Y499/01001
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a ferrochelatase.
摘要翻译： 用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。 重组DNA构建体包含可操作地连接到在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码铁螯合酶。
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公开(公告)号：US20230365657A1
公开(公告)日：2023-11-16
申请号：US18307144
申请日：2023-04-26
IPC分类号： C07K14/805 , C12N15/82 , A23L13/40 , A23J3/22
CPC分类号： C07K14/805 , C12Y499/01001 , C12N15/8257 , A23L13/424 , A23J3/227 , C12N15/8243
摘要： This disclosure provides for methods and compositions for the expression and secretion of heme-containing polypeptides.
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10.发明授权公开(公告)号：US07625738B1
公开(公告)日：2009-12-01
申请号：US11329175
申请日：2006-01-11
申请人： Claire A. CaJacob , Jingdong Liu
发明人： Claire A. CaJacob , Jingdong Liu
CPC分类号： C12N9/88 , C12Y499/01001
摘要： The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tetrapyrrole pathway. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.
摘要翻译： 本发明在植物生物化学领域。 更具体地，本发明涉及来自植物细胞的核酸序列，特别是涉及四吡咯途径的玉米和大豆的核酸序列。 本发明包括编码蛋白质和蛋白质片段的核酸分子。 此外，本发明还包括如此编码的蛋白质和蛋白质的片段以及能够结合这些蛋白质或片段的抗体。 本发明还涉及使用核酸分子，蛋白质和蛋白质和抗体片段的方法，例如用于基因组图谱，基因鉴定和分析，植物育种，用于植物基因表达的构建体的制备和转基因植物。
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