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公开(公告)号：US20100279348A1
公开(公告)日：2010-11-04
申请号：US12744959
申请日：2008-12-15
申请人： Juergen Nett
发明人： Juergen Nett
CPC分类号： C12N15/815 , C12N9/88 , C12N2800/102 , C12Y401/01021
摘要： Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.
摘要翻译： 公开了基于ade1和ade2营养缺陷菌株的酵母和真菌，包括巴斯德毕赤酵母的表达系统的方法和系统。 表达系统对于提高转化细胞系的细胞生产力和用于在工业规模生产重组糖蛋白是有用的。
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2.发明申请公开(公告)号：US20160369281A1
公开(公告)日：2016-12-22
申请号：US14741158
申请日：2015-06-16
发明人： Xionglei HE
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/14 , C12Y401/01021 , C12Y403/02002 , C12Y603/02006
摘要： The present invention discloses target point, preparation and method for treating human ADSL deficiency. The present invention established an ADSL deficiency retrieval model in nematode through RNA interference technique, and found that the sole RNA interference with PAICS gene could increase the expression of ADSL gene. Based on the conclusion of nematode model study, it can be foreseen that through interference with PAICS gene expression in ADSL deficient patient, accumulation of SAICAR in patient body fluid will be decreased and thereby reducing damage to cells, achieving the object of treating human ADSL deficiency or relieving symptoms.
摘要翻译： 本发明公开了治疗ADSL缺陷的靶点，制备方法和方法。 本发明通过RNA干扰技术建立了线虫ADSL缺陷检测模型，发现单链RNA干扰PAICS基因可增加ADSL基因的表达。 根据线虫模型研究的结论，可以预见，通过干扰ADSL缺陷患者PAICS基因表达，SAICAR在患者体液中的积累将降低，从而减少对细胞的损伤，达到治疗人ADSL缺陷的目的 或缓解症状。
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公开(公告)号：US20150361438A1
公开(公告)日：2015-12-17
申请号：US14836203
申请日：2015-08-26
申请人： GLYCOFI, INC.
发明人： Juergen Nett
CPC分类号： C12N15/815 , C12N9/88 , C12N2800/102 , C12Y401/01021
摘要： Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.
摘要翻译： 公开了基于ade1和ade2营养缺陷菌株的酵母和真菌，包括巴斯德毕赤酵母的表达系统的方法和系统。 表达系统对于提高转化细胞系的细胞生产力和用于在工业规模生产重组糖蛋白是有用的。
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公开(公告)号：US20030229916A1
公开(公告)日：2003-12-11
申请号：US10323167
申请日：2002-12-19
IPC分类号： A01H001/00 , C12N015/82 , C07H021/04 , C12N009/10 , C12P021/02 , C12N005/04
CPC分类号： C12Y401/01021 , C12N9/88
摘要： This invention relates to an isolated nucleic acid fragment encoding a phosphoribosylaminoimidazole carboxylase. The invention also relates to the construction of a recombinant DNA construct or chimeric gene encoding all or a portion of the phosphoribosylaminoimidazole carboxylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct or chimeric gene results in production of altered levels of the phosphoribosylaminoimidazole carboxylase in a transformed host cell.
摘要翻译： 本发明涉及编码磷酸核糖基氨基咪唑羧化酶的分离的核酸片段。 本发明还涉及在正义或反义方向上构建编码全部或一部分磷酸核糖基氨基咪唑羧化酶的重组DNA构建体或嵌合基因，其中重组DNA构建体或嵌合基因的表达导致产生改变的磷酸核糖基氨基咪唑水平 羧化酶在转化的宿主细胞中。
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公开(公告)号：US10059952B2
公开(公告)日：2018-08-28
申请号：US14836203
申请日：2015-08-26
申请人： GLYCOFI, INC.
发明人： Juergen Nett
CPC分类号： C12N15/815 , C12N9/88 , C12N2800/102 , C12Y401/01021
摘要： Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.
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公开(公告)号：US09133464B2
公开(公告)日：2015-09-15
申请号：US12744959
申请日：2008-12-15
申请人： Juergen Nett
发明人： Juergen Nett
CPC分类号： C12N15/815 , C12N9/88 , C12N2800/102 , C12Y401/01021
摘要： Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.
摘要翻译： 公开了基于ade1和ade2营养缺陷菌株的酵母和真菌，包括巴斯德毕赤酵母的表达系统的方法和系统。 表达系统对于提高转化细胞系的细胞生产力和用于在工业规模生产重组糖蛋白是有用的。
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