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公开(公告)号：US20200330402A1
公开(公告)日：2020-10-22
申请号：US16497305
申请日：2018-02-06
发明人： WEI ZHU , WUGUANG PAN
IPC分类号： A61K31/132
摘要： Applications of spermine or its pharmaceutically acceptable derivative in preparation of an SAICAR synthetase activity interfering agent or inhibitor. Applications of spermine or its pharmaceutically acceptable derivative in preparation of antitumor drug.
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公开(公告)号：US20210008012A1
公开(公告)日：2021-01-14
申请号：US16979848
申请日：2017-12-11
发明人： Wuguang PAN , Wei ZHU
IPC分类号： A61K31/145
摘要： Provided are applications of disulfiram and derivatives thereof. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or reducing ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
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公开(公告)号：US11684593B2
公开(公告)日：2023-06-27
申请号：US16497305
申请日：2018-02-06
发明人： Wei Zhu , Wuguang Pan
IPC分类号： A61K31/132 , A61P35/00 , A61K45/06
CPC分类号： A61K31/132 , A61P35/00 , A61K45/06
摘要： Applications of spermine or its pharmaceutically acceptable derivative in preparation of an SAICAR synthetase activity interfering agent or inhibitor. Applications of spermine or its pharmaceutically acceptable derivative in preparation of antitumor drug.
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公开(公告)号：US20190209499A1
公开(公告)日：2019-07-11
申请号：US16334256
申请日：2017-09-26
发明人： Wuguang PAN , Wei ZHU
IPC分类号： A61K31/155 , A61P35/00 , A61K38/05 , A61K38/06 , A61K31/661 , A61K31/132 , A61K31/198 , A61K31/7076 , A61K31/675 , A61K31/415 , A61K31/4402 , A61K31/513
CPC分类号： A61K31/155 , A61K31/132 , A61K31/197 , A61K31/198 , A61K31/33 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4188 , A61K31/43 , A61K31/435 , A61K31/4402 , A61K31/513 , A61K31/661 , A61K31/675 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/05 , A61K38/06 , A61K38/063 , A61K38/07 , A61P3/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P35/00 , A61P43/00 , C07D213/00 , C07D403/00 , C07D487/00 , C07D513/00 , C07H19/20 , C07H21/00
摘要： Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
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公开(公告)号：US11766412B2
公开(公告)日：2023-09-26
申请号：US16334256
申请日：2017-09-26
发明人： Wuguang Pan , Wei Zhu
IPC分类号： A61K31/132 , A61K31/155 , A61K38/05 , A61K38/06 , A61P25/00 , A61P35/00 , A61K31/661 , A61K31/513 , A61K31/198 , A61K31/7076 , A61K31/675 , A61K31/415 , A61K31/4402 , A61K31/197 , A61K31/4188 , A61K31/708 , C07D213/66 , C07D213/77 , C07D405/04 , C07D401/04 , A61K31/43 , A61P3/00 , C07D261/04 , C07D207/12 , A61P25/14 , A61K31/33 , C07D473/34 , A61K38/07 , A61K31/397 , A61K31/7072 , A61P25/08 , A61K31/40 , A61P43/00 , A61K31/435
CPC分类号： A61K31/155 , A61K31/132 , A61K31/197 , A61K31/198 , A61K31/33 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4188 , A61K31/43 , A61K31/435 , A61K31/4402 , A61K31/513 , A61K31/661 , A61K31/675 , A61K31/708 , A61K31/7072 , A61K31/7076 , A61K38/05 , A61K38/06 , A61K38/063 , A61K38/07 , A61P3/00 , A61P25/00 , A61P25/08 , A61P25/14 , A61P35/00 , A61P43/00 , C07D207/12 , C07D213/66 , C07D213/77 , C07D261/04 , C07D401/04 , C07D405/04 , C07D473/34
摘要： Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
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公开(公告)号：US20230288401A1
公开(公告)日：2023-09-14
申请号：US18200591
申请日：2023-05-23
发明人： Wuguang Pan , Wei Zhu
IPC分类号： G01N33/50 , A61P35/00 , A61K45/06 , A61K31/5383
CPC分类号： G01N33/5011 , A61P35/00 , A61K45/06 , A61K31/5383
摘要： The present invention discloses application of compounds in the preparation of reagents for down-regulation of Runx2. The inventors have confirmed through computational studies and disease models that Fostamatinib, Regorafenib and melatonin can significantly down-regulate the expression of Runx2, and have a significant targeted therapeutic effect on cancers with abnormally high expression of Runx2, and are efficient reagents for reducing the expression of Runx2. Especially the Runx2 expression down-regulation reagent used in the laboratory.
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公开(公告)号：US11517541B2
公开(公告)日：2022-12-06
申请号：US16606655
申请日：2018-03-12
发明人： Wei Zhu , Wuguang Pan
IPC分类号： A61K31/132
摘要： Disclosed are applications of spermidine or its pharmaceutically acceptable derivatives. The inventors performed calculation and analysis using software based on existing data relating to protein and small-molecule structures, and screened out compounds which can effectively interfere with the activity of PAWS and thus reduce SAICAR synthesis, thereby achieving the goal of treating or improving tumors. It is expected to produce better effect in the treatment or improvement of tumors.
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公开(公告)号：US20200330403A1
公开(公告)日：2020-10-22
申请号：US16606655
申请日：2018-03-12
发明人： WEI ZHU , WUGUANG PAN
IPC分类号： A61K31/132
摘要： Disclosed are applications of spermidine or its pharmaceutically acceptable derivatives. The inventors performed calculation and analysis using software based on existing data relating to protein and small-molecule structures, and screened out compounds which can effectively interfere with the activity of PAICS and thus reduce SAICAR synthesis, thereby achieving the goal of treating or improving tumors. It is expected to produce better effect in the treatment or improvement of tumors.
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公开(公告)号：US20200297660A1
公开(公告)日：2020-09-24
申请号：US16889500
申请日：2020-06-01
发明人： Wuguang PAN , Wei Zhu
IPC分类号： A61K31/132 , C07C209/00 , C07D501/57 , A61P3/00 , A61K31/663 , A61K38/17 , A61K31/16 , A61K38/06 , A61K31/407 , A61P25/14 , A61K31/198 , C07F9/90 , C07C221/00 , A61P43/00 , C07D405/14 , A61K31/427 , A61P25/08 , C07C249/00 , A61K8/41 , A61K31/00 , A61K31/341
摘要： This disclosure relates to a method for treating a disease which can be alleviated by inhibiting PAICS activity. The method includes administering a therapeutically effective amount of spermine or a pharmaceutically acceptable salt or C1-C6 amide thereof to a patient in need thereof.
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公开(公告)号：US10709676B2
公开(公告)日：2020-07-14
申请号：US16334273
申请日：2017-09-08
发明人： Wuguang Pan , Wei Zhu
IPC分类号： A61K31/132 , C07C209/00 , C07D501/57 , A61P3/00 , A61K31/663 , A61K38/17 , A61K31/16 , A61K38/06 , A61K31/407 , A61P25/14 , A61K31/198 , C07F9/90 , C07C221/00 , A61P43/00 , C07D405/14 , A61K31/427 , A61P25/08 , C07C249/00 , A61K8/41 , A61K31/00 , A61K31/341
摘要： Provided are applications of spermine and derivatives thereof. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or reducing ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
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