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公开(公告)号：US20170312318A1
公开(公告)日：2017-11-02
申请号：US15595576
申请日：2017-05-15
Inventor： Bruno DOIRON , Ralph A. DEFRANZO
IPC: A61K35/39 , A61K38/17 , A61K38/45 , C12N15/113 , A61K31/7088 , C12N9/12 , C12N9/16 , C07K14/47 , A61K48/00
CPC classification number: A61K35/39 , A61K31/7088 , A61K38/1709 , A61K38/45 , A61K48/00 , C07K14/4702 , C12N9/1205 , C12N9/16 , C12N15/1137 , C12N2320/31 , C12N2330/51 , C12N2740/15043 , C12Y207/01002 , C12Y301/03048 , C12N2310/14 , C12N2310/531
Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes. In certain aspects, the methods include the integration of three levels of cellular physiology: metabolism, membrane receptor function, and gene transcription. The integration of multiple levels of cellular physiology produces a synergistic effect on beta cell formation.
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公开(公告)号：US09732329B2
公开(公告)日：2017-08-15
申请号：US15053992
申请日：2016-02-25
Applicant: University of Technology, Sydney
Inventor： Ann Margaret Simpson , Chang Tao
IPC: C12N5/071 , A61K35/407 , A61K38/45 , C12N9/12 , A61K38/28 , C07K14/62 , C12N15/85 , A61K35/12 , A61K48/00
CPC classification number: C12N9/1205 , A61K35/12 , A61K35/407 , A61K38/28 , A61K38/45 , A61K48/00 , C07K14/62 , C12N5/067 , C12N15/85 , C12N2501/33 , C12N2510/00 , C12N2830/20 , C12Y207/01002
Abstract: The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells genetically modified to produce insulin in response to physiologically relevant levels of glucose and uses thereof. The cells of the present invention are useful in a wide variety of applications, in particular in the context of therapeutic and prophylactic regimes directed to the treatment of diabetes and/or the amelioration of symptoms associated with diabetes, based on the transplantation of the cells of the present invention into mammals requiring treatment. Also facilitated is the design of in vitro based screening systems for testing the therapeutic effectiveness and/or toxicity of potential adjunctive treatment regimes.
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公开(公告)号：US07250285B2
公开(公告)日：2007-07-31
申请号：US11403784
申请日：2006-04-13
Applicant: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
Inventor： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
CPC classification number: C12N9/1077 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002
Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
Abstract translation: 本发明提供了编码这种多肽的新型多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用这些多肽筛选抗菌化合物的方法。
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4.发明申请Gene for thermostable glucokinase, recombinant vector containing the same, transformant containing the recombinant vector and process for producing thermostable glucokinase using the transformant 失效用于热稳定性葡糖激酶的基因，含有该重组载体的重组载体，含有重组载体的转化体和使用转化体产生热稳定性葡萄糖激酶的方法公开(公告)号：US20020110863A1
公开(公告)日：2002-08-15
申请号：US10043238
申请日：2002-01-14
Applicant: UNITIKA LTD.
Inventor： Shido Kawase , Keisuke Kurosaka
IPC: C12P021/02 , C12N005/06 , C07H021/04 , C12N009/12
CPC classification number: C12N9/1205 , C12Y207/01002
Abstract: A gene encoding thermostable glucokinase, a recombinant vector comprising this gene, a transformant transformed with the recombinant vector, and a process for producing thermostable glucokinase with the use of the transformant.
Abstract translation: 编码热稳定性葡萄糖激酶的基因，包含该基因的重组载体，用重组载体转化的转化体，以及使用转化体产生热稳定性葡萄糖激酶的方法。
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公开(公告)号：US6025175A
公开(公告)日：2000-02-15
申请号：US110910
申请日：1998-07-06
Applicant: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
Inventor： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , Martin Karl Russel Burnham
IPC: A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N9/12 , C12N9/78 , C12N15/54 , C07K16/00 , C12N15/00 , C12Q1/68
CPC classification number: C12N9/1205 , C07K14/3156 , C12N9/78 , C12Y207/01002 , A61K38/00 , A61K39/00
Abstract: The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
Abstract translation: 本发明提供了葡萄糖激酶多肽和编码葡萄糖激酶多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用葡萄糖激酶多肽筛选抗菌化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20240287565A1
公开(公告)日：2024-08-29
申请号：US18546949
申请日：2022-02-22
Applicant: Chr. Hansen A/S
Inventor： Vojislav VOJINOVIC , Kim Ib SOERENSEN , Laurent GUINOT
CPC classification number: C12P19/12 , A23C9/1238 , C12N1/20 , C12N9/1205 , C12R2001/46 , C12Y207/01002 , C12Y207/01006
Abstract: The invention relates to a method of obtaining a composition comprising allolactose by a applying one or more glucose-deficient lactic acid bacteria strains. The invention also relates to the use of said strains for the preparation of a food product comprising allolactose and to the use of said strains for increasing the content of allolactose in a food product. The invention also relates to a food product comprising allolactose and one or more glucose-deficient lactic acid bacteria strains.
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公开(公告)号：US20180195073A1
公开(公告)日：2018-07-12
申请号：US15849776
申请日：2017-12-21
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Kevin Fitzgerald , David Erbe , Gregory Hinkle
IPC: C12N15/113 , A61K45/06 , A61K31/713
CPC classification number: C12N15/1137 , A61K31/713 , A61K45/06 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12Y207/01002
Abstract: The invention relates to double stranded ribonucleic acid (dsRNA) compositions targeting a glucokinase (GCK) gene, as well as methods of inhibiting expression of a glucokinase (GCK) gene, and methods of treating subjects having a glycogen storage disease (GSD), e.g., type Ia GSD.
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8.发明申请公开(公告)号：US20170145449A1
公开(公告)日：2017-05-25
申请号：US15316392
申请日：2015-06-11
Inventor： Jean-Marc NICAUD , Zbigniew LAZAR , Thierry DULERMO , Anne-Marie CRUTZ-LE COQ
CPC classification number: C12P7/6409 , C07K14/39 , C07K14/395 , C12N9/0006 , C12N9/1029 , C12N9/1205 , C12N9/2431 , C12N15/815 , C12P7/6427 , C12Y101/01008 , C12Y203/0102 , C12Y207/01001 , C12Y207/01002 , C12Y207/01004 , C12Y302/01026
Abstract: The present invention relates to oleaginous yeast strains overexpressing a hexokinase gene, wherein said strains are capable of accumulating lipids. Methods for obtaining said strains as well as methods for producing lipids are also disclosed.
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9.发明授权Cells genetically modified to comprise pancreatic islet glucokinase and uses thereof 有权遗传修饰的细胞包含胰岛素葡糖激酶及其用途公开(公告)号：US09365829B2
公开(公告)日：2016-06-14
申请号：US14185716
申请日：2014-02-20
Applicant: University of Technology, Sydney
Inventor： Ann Margaret Simpson , Chang Tao
IPC: C12N5/071 , A61K35/407 , A61K38/45 , C12N9/12 , A61K38/28 , C07K14/62 , C12N15/85 , A61K35/12 , A61K48/00
CPC classification number: C12N9/1205 , A61K35/12 , A61K35/407 , A61K38/28 , A61K38/45 , A61K48/00 , C07K14/62 , C12N5/067 , C12N15/85 , C12N2501/33 , C12N2510/00 , C12N2830/20 , C12Y207/01002
Abstract: The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells genetically modified to produce insulin in response to physiologically relevant levels of glucose and uses thereof. The cells of the present invention are useful in a wide variety of applications, in particular in the context of therapeutic and prophylactic regimes directed to the treatment of diabetes and/or the amelioration of symptoms associated with diabetes, based on the transplantation of the cells of the present invention into mammals requiring treatment. Also facilitated is the design of in vitro based screening systems for testing the therapeutic effectiveness and/or toxicity of potential adjunctive treatment regimes.
Abstract translation: 本发明一般涉及遗传修饰以以葡萄糖反应的方式产生胰岛素的细胞群及其用途。 更具体地，本发明涉及基于生理学上相关的葡萄糖水平及其用途而被遗传修饰以产生胰岛素的细胞群。 本发明的细胞可用于各种各样的应用，特别是在针对糖尿病的治疗和/或改善与糖尿病相关的症状的治疗和预防方案的背景下，基于细胞的移植 本发明涉及需要治疗的哺乳动物。 还促进了用于测试潜在辅助治疗方案的治疗有效性和/或毒性的基于体外的筛选系统的设计。
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公开(公告)号：US06284878B1
公开(公告)日：2001-09-04
申请号：US08991023
申请日：1997-12-15
Applicant: Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
Inventor： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
IPC: C07H2102
CPC classification number: C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/78 , C12N9/80 , C12Y207/01002
Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
Abstract translation: 本发明提供了def1多肽和编码def1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用def1多肽筛选抗菌化合物的方法。
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