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公开(公告)号：US20180344842A1
公开(公告)日：2018-12-06
申请号：US16007135
申请日：2018-06-13
发明人： David B. Weiner , Jian Yan , Matthew Morrow
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K2319/02 , C07K2319/42 , C12N7/00 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
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2.发明申请METHODS AND COMPOSITIONS TO MODULATE ANTIVIRAL AND IMMUNE ACTIVITY RESPONSES 审中-公开调节抗病毒和免疫活性反应的方法和组合物公开(公告)号：US20140341908A1
公开(公告)日：2014-11-20
申请号：US14283014
申请日：2014-05-20
发明人： Carrie M. ROSENBERGER , Alan ADEREM
IPC分类号： C12N15/113 , C12N15/86 , C12N7/00 , C07K16/44
CPC分类号： C12N15/113 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C07K16/44 , C07K2317/76 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2760/16041 , C12N2760/16134 , C12N2760/16151 , C12N2799/021 , C12N2330/10
摘要： The invention is directed to an improved method to manufacture virus for use in vaccine by culturing infected cells that have been modified to overexpress miR-144. The invention is also directed to manipulating the activity or level of miR-144 in subjects in order to modulate the antiviral and immune response systems.
摘要翻译： 本发明涉及通过培养经过修饰以过表达miR-144的感染细胞来制造用于疫苗的病毒的改进方法。 本发明还涉及操纵受试者中miR-144的活性或水平以调节抗病毒和免疫应答系统。
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公开(公告)号：US20190192650A1
公开(公告)日：2019-06-27
申请号：US16298006
申请日：2019-03-11
发明人： David Weiner , Jian Yan
IPC分类号： A61K39/12 , A61N1/32 , C07K14/005
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/70 , A61N1/327 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/42 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
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公开(公告)号：US20150056653A1
公开(公告)日：2015-02-26
申请号：US14235908
申请日：2012-07-27
申请人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
发明人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
IPC分类号： C07K14/005 , C12N7/00 , C07K14/255
CPC分类号： C12P21/02 , A61K39/00 , B01D15/327 , B01D15/363 , C07K1/18 , C07K14/005 , C07K14/195 , C07K14/255 , C07K2319/30 , C07K2319/40 , C07K2319/42 , C12N7/00 , C12N2760/16031 , C12N2760/16033 , C12N2760/16034 , C12N2760/16041 , C12N2760/16051
摘要： Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
摘要翻译： 本文提供了产生异源多肽的方法及其组合物。
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公开(公告)号：US11844830B2
公开(公告)日：2023-12-19
申请号：US17141704
申请日：2021-01-05
发明人： David Weiner , Jian Yan
IPC分类号： A61K39/12 , C07K14/025 , C07K14/005 , A61K39/145 , C12N7/00 , A61N1/32 , A61K39/00
CPC分类号： A61K39/12 , A61K39/145 , A61N1/327 , C07K14/005 , C12N7/00 , A61K2039/53 , A61K2039/54 , A61K2039/70 , C07K2319/00 , C07K2319/02 , C07K2319/42 , C12N2710/20022 , C12N2710/20034 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
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公开(公告)号：US20170114383A1
公开(公告)日：2017-04-27
申请号：US15400291
申请日：2017-01-06
发明人： George E. Pierce , Susan A. Burran , Trudy Ann Tucker , Shelby Jones-Dozier , Jennifer Hooker , Sidney A. Crow, JR.
IPC分类号： C12P21/02 , B01D15/32 , C07K14/005 , B01D15/36 , C07K1/18 , C07K14/255
CPC分类号： C12P21/02 , A61K39/00 , B01D15/327 , B01D15/363 , C07K1/18 , C07K14/005 , C07K14/195 , C07K14/255 , C07K2319/30 , C07K2319/40 , C07K2319/42 , C12N7/00 , C12N2760/16031 , C12N2760/16033 , C12N2760/16034 , C12N2760/16041 , C12N2760/16051
摘要： Provided herein are methods of producing a heterologous polypeptide and compositions comprising same.
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公开(公告)号：US20160038584A1
公开(公告)日：2016-02-11
申请号：US14774256
申请日：2014-03-12
申请人： David WEINER , Jian YAN , INOVIO PHARMACEUTICALS, INC. , The Trustees of the University of Pennsylvania
发明人： David B. Weiner , Jian Yan , Matthew Morrow
IPC分类号： A61K39/145 , C12N7/00 , C07K14/005
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K2319/02 , C07K2319/42 , C12N7/00 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
摘要翻译： 本文提供了编码HA血凝素和/或乙型血凝素的新共识氨基酸序列以及表达序列的遗传构建体/载体和疫苗的核酸序列。 本文还提供了使用提供的疫苗产生针对一种或多种甲型流感血清型和/或流感乙型血清型或其组合的免疫应答的方法。
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公开(公告)号：US20160022806A1
公开(公告)日：2016-01-28
申请号：US14774241
申请日：2014-03-12
申请人： David Weiner , Jian Yan , Matthew Morrow
发明人： David B. Weiner , Jian Yan , Matthew Morrow
IPC分类号： A61K39/145 , C12N7/00 , C07K14/005
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K2319/02 , C07K2319/42 , C12N7/00 , C12N2760/16022 , C12N2760/16034 , C12N2760/16041 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2800/22
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
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9.发明授权公开(公告)号：US08747860B2
公开(公告)日：2014-06-10
申请号：US13542581
申请日：2012-07-05
CPC分类号： C12N15/113 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C07K16/44 , C07K2317/76 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2760/16041 , C12N2760/16134 , C12N2760/16151 , C12N2799/021 , C12N2330/10
摘要： The invention is directed to an improved method to manufacture virus for use in vaccine by culturing infected cells that have been modified to overexpress miR-144. The invention is also directed to manipulating the activity or level of miR-144 in subjects in order to modulate the antiviral and immune response systems.
摘要翻译： 本发明涉及通过培养经过修饰以过表达miR-144的感染细胞来制造用于疫苗的病毒的改进方法。 本发明还涉及操纵受试者中miR-144的活性或水平以调节抗病毒和免疫应答系统。
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10.发明申请公开(公告)号：US20130022602A1
公开(公告)日：2013-01-24
申请号：US13542581
申请日：2012-07-05
IPC分类号： A61K39/12 , A61K39/395 , C07H21/00 , C07H21/02 , A61P37/04 , A61P37/06 , A61P31/12 , A61P31/04 , A61P31/10 , A61P33/02 , C12N7/02 , C12N7/04 , C12N5/10 , C12N15/63 , C12N15/86 , A61K31/7088
CPC分类号： C12N15/113 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , C07K16/44 , C07K2317/76 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2760/16041 , C12N2760/16134 , C12N2760/16151 , C12N2799/021 , C12N2330/10
摘要： The invention is directed to an improved method to manufacture virus for use in vaccine by culturing infected cells that have been modified to overexpress miR-144. The invention is also directed to manipulating the activity or level of miR-144 in subjects in order to modulate the antiviral and immune response systems.
摘要翻译： 本发明涉及通过培养经过修饰以过表达miR-144的感染细胞来制造用于疫苗的病毒的改进方法。 本发明还涉及操纵受试者中miR-144的活性或水平以调节抗病毒和免疫应答系统。
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