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1.发明申请公开(公告)号：US20140100199A1
公开(公告)日：2014-04-10
申请号：US14041539
申请日：2013-09-30
Applicant: Allergan, Inc.
Inventor： Janet A. Takeuchi , Ling Li , Wha-Bin Im , Ken Chow
IPC: C07F9/653
CPC classification number: C07F9/6503 , C07D271/06 , C07F9/65306 , C07F9/65318 , C07F9/65586
Abstract: The present invention relates to substituted aryl 1,2,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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公开(公告)号：US20090253699A1
公开(公告)日：2009-10-08
申请号：US11577191
申请日：2005-10-13
Applicant: Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
Inventor： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC: A61K31/5377 , A61K31/4245 , C07D271/10 , C12N5/00 , C07D413/02 , A61K31/433 , C07D285/12 , A61K31/421 , C07D263/30 , A61K31/415 , C07D231/10 , A61K31/426 , C07D277/20 , C07D307/02 , A61K31/34 , A61P37/06 , A61P7/00 , A61P25/00 , A61P9/00 , A61P29/00
CPC classification number: C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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3.发明授权2-thio-1,3,4-oxadiazoles derivatives as sphingosine-1 phosphate receptors modulators 有权2-硫代-1,3,4-恶二唑衍生物作为鞘氨醇-1磷酸受体调节剂公开(公告)号：US08729110B1
公开(公告)日：2014-05-20
申请号：US14073970
申请日：2013-11-07
Applicant: Allergan, Inc.
Inventor： Janet A. Takeuchi , Ling Li , Wha-Bin Im , Ken Chow
IPC: A61K31/4245 , C07D271/07
CPC classification number: C07D271/07 , C07D271/113 , C07D413/06 , C07F9/65306 , C07F9/65312 , C07F9/65586
Abstract: The present invention relates to novel 2-thio-1,3,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract translation: 本发明涉及新的2-硫代-1,3,4-恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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4.发明授权Substituted aryl 1 ,2,4-oxadiazoles derivatives as sphingosine-1 phosphate receptors modulators 失效取代的芳基1,2,4-恶二唑衍生物作为鞘氨醇-1磷酸受体调节剂公开(公告)号：US08722712B2
公开(公告)日：2014-05-13
申请号：US14041539
申请日：2013-09-30
Applicant: Allergan, Inc.
Inventor： Janet A. Takeuchi , Ling Li , Wha-Bin Im , Ken Chow
IPC: A61K31/4245 , C07D271/06
CPC classification number: C07F9/6503 , C07D271/06 , C07F9/65306 , C07F9/65318 , C07F9/65586
Abstract: The present invention relates to substituted aryl 1,2,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Abstract translation: 本发明涉及取代的芳基-1,2,4-恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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5.发明申请Pyrazole or Triazole Compounds and Their Use for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases 有权吡唑或三唑化合物及其用于制造治疗体细胞突变相关疾病的药物的用途公开(公告)号：US20080280869A1
公开(公告)日：2008-11-13
申请号：US11577177
申请日：2005-10-13
Applicant: Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
Inventor： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
IPC: A61K31/4196 , C07D233/88 , C07D249/08 , C07D231/12 , C07D491/04 , C07D271/06 , A61P35/00 , C12N5/06 , A61P37/02 , A61K31/4245 , A61K31/415 , C07D403/10 , A61K31/4168
CPC classification number: C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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Patent Agency Ranking
公开(公告)号：US20170204073A1
公开(公告)日：2017-07-20
申请号：US15475240
申请日：2017-03-31
Applicant: PTC Therapeutics, Inc.
Inventor： Neil Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC: C07D271/06 , C07D413/06 , C07D417/04 , C07D413/04
CPC classification number: C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
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公开(公告)号：US09273076B2
公开(公告)日：2016-03-01
申请号：US14263478
申请日：2014-04-28
Applicant: PTC Therapeutics, Inc.
Inventor： Jeffrey A. Campbell , Atiyya Kahn , James Takasugi , Ellen Welch
IPC: A61K31/675 , A61K31/535 , A61K31/497 , A61K31/505 , A61K31/445 , A61K31/41 , C07F9/653 , C07D231/12 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D413/12
CPC classification number: C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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8.发明申请PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES 审中-公开吡唑或三唑化合物及其用于制造治疗皮肤相关疾病的药物的用途公开(公告)号：US20150274674A1
公开(公告)日：2015-10-01
申请号：US14733615
申请日：2015-06-08
Applicant: PTC THERAPEUTICS, INC.
Inventor： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
IPC: C07D231/12 , C07D413/04 , C07D409/04 , C07D401/04 , C07D405/04 , C07D403/04
CPC classification number: C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：US20110160164A1
公开(公告)日：2011-06-30
申请号：US13042456
申请日：2011-03-07
Applicant: Jeffrey A. Campbell , Atiyya Kahn , James Takasugi , Ellen Welch
Inventor： Jeffrey A. Campbell , Atiyya Kahn , James Takasugi , Ellen Welch
IPC: A61K31/4245 , A61K31/506 , A61K31/4439 , A61K31/5377 , A61K31/454 , A61K31/675 , A61K31/496 , A61P37/06 , A61P25/28 , A61P9/00 , A61P3/10 , A61P11/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P25/16 , A61P7/00 , A61P7/04 , A61P13/12 , A61P3/06 , A61P9/10 , A61P43/00 , A61P3/04
CPC classification number: C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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10.发明申请Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases 审中-公开无意义抑制的化合物，这些化合物用于制造用于治疗体细胞突变相关疾病的药物的用途公开(公告)号：US20080269191A1
公开(公告)日：2008-10-30
申请号：US11577176
申请日：2005-10-13
Applicant: Richard Wilde , Ellen Welch , Gary M. Karp
Inventor： Richard Wilde , Ellen Welch , Gary M. Karp
IPC: A61K31/4439 , C07D413/04 , A61K31/423 , C07D263/57 , C07D413/14 , A61P35/00 , C12N5/06
CPC classification number: C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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