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公开(公告)号：US20130209467A1
公开(公告)日：2013-08-15
申请号：US13856035
申请日：2013-04-03
申请人： ZYMOGENETICS, INC.
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US20100179052A1
公开(公告)日：2010-07-15
申请号：US12354400
申请日：2009-01-15
申请人： Jonathan Brooks
发明人： Jonathan Brooks
IPC分类号： C04B33/36
CPC分类号： C04B33/04 , B28B1/525 , C04B28/001 , C04B33/132 , C04B35/6263 , C04B35/6365 , C04B2111/00224 , C04B2111/00956 , C04B2235/6021 , Y02P40/69 , Y02W30/97 , C04B18/26 , C04B40/0071 , C04B40/0089 , C04B40/0263
摘要： A clay-pulp mixture is prepared by blending a predetermined ratio of clay and wood pulp derived from alpha virgin cellulose in dry form, moistening the mixture homogeneously by adding water and continuing to blend until a malleable consistency is achieved. Air is extracted from the moist mixture, and solid blocks formed for storage and delivery to end-users.
摘要翻译： 通过将干燥形式的来自α原始纤维素的预定比例的粘土和木浆混合，通过加入水均匀地润湿混合物并继续混合直到达到可延展稠度来制备粘土 - 纸浆混合物。 从潮湿的混合物中提取空气，形成固体块，用于储存和输送给最终用户。
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公开(公告)号：US07722870B2
公开(公告)日：2010-05-25
申请号：US11539271
申请日：2006-10-06
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US07514238B2
公开(公告)日：2009-04-07
申请号：US11550237
申请日：2006-10-17
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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5.发明授权Methods of treating fibroproliferative disorders of the kidney or reducing kidney fibrosis 有权治疗肾纤维增生性疾病或减少肾纤维化的方法公开(公告)号：US08834879B2
公开(公告)日：2014-09-16
申请号：US13856035
申请日：2013-04-03
申请人： ZymoGenetics, Inc.
IPC分类号： A61K39/395 , C07K16/18 , C07K16/22 , C07K14/475
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US20090227022A1
公开(公告)日：2009-09-10
申请号：US12363540
申请日：2009-01-30
IPC分类号： C12N5/02
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20070048316A1
公开(公告)日：2007-03-01
申请号：US11538706
申请日：2006-10-04
申请人： CHARLES HART , STAVROS TOPOUZIS , DEBRA GILBERTSON
发明人： CHARLES HART , STAVROS TOPOUZIS , DEBRA GILBERTSON
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US07172757B2
公开(公告)日：2007-02-06
申请号：US10606055
申请日：2003-06-25
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US20050031694A1
公开(公告)日：2005-02-10
申请号：US10910938
申请日：2004-08-03
申请人： Debra Gilbertson , Charles Hart
发明人： Debra Gilbertson , Charles Hart
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
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公开(公告)号：US06495668B1
公开(公告)日：2002-12-17
申请号：US09564595
申请日：2000-05-03
IPC分类号： A61K3824
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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