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公开(公告)号：US08124065B2
公开(公告)日：2012-02-28
申请号：US13028101
申请日：2011-02-15
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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2.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 有权使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20110177024A1
公开(公告)日：2011-07-21
申请号：US13042210
申请日：2011-03-07
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
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3.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 审中-公开使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20100298230A1
公开(公告)日：2010-11-25
申请号：US12611067
申请日：2009-11-02
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
IPC分类号： A61K38/16 , A61K31/711 , A61P25/28
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
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4.发明申请A METHOD OF USING INTERFERON-LIKE PROTEIN ZCYTO21(IL-29) TO TREAT HEPATITIS B 有权使用干扰素蛋白ZCYTO21（IL-29）治疗乙型肝炎的方法公开(公告)号：US20100222266A1
公开(公告)日：2010-09-02
申请号：US12628078
申请日：2009-11-30
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-a at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US20100167391A1
公开(公告)日：2010-07-01
申请号：US12107571
申请日：2008-04-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N5/071
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07691981B2
公开(公告)日：2010-04-06
申请号：US11552378
申请日：2006-10-24
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
IPC分类号： C12N15/00
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07662927B2
公开(公告)日：2010-02-16
申请号：US12201399
申请日：2008-08-29
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US07655447B2
公开(公告)日：2010-02-02
申请号：US12239535
申请日：2008-09-26
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US20090270333A1
公开(公告)日：2009-10-29
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/10 , C07H21/04 , C12N15/63 , C12N5/10 , C07K7/08 , C07K14/00 , C07K16/00 , C12P21/00 , A61P1/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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公开(公告)号：US07608427B2
公开(公告)日：2009-10-27
申请号：US11550284
申请日：2006-10-17
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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