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公开(公告)号：US09790485B2
公开(公告)日：2017-10-17
申请号：US14634042
申请日：2015-02-27
申请人： Covaris, Inc.
CPC分类号： C12N13/00 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N1/286 , G01N2035/00554
摘要： Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
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公开(公告)号：US20130177922A1
公开(公告)日：2013-07-11
申请号：US13711807
申请日：2012-12-12
申请人： Covaris, Inc.
IPC分类号： G01N1/28
CPC分类号： C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
摘要： This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
摘要翻译： 本发明涉及向样品施加声能的系统和方法。 根据本发明的一个方面，一种系统包括壳体，用于接收样品的腔室，用于根据治疗方案向样品提供聚焦声场的声能源，用于确定治疗方案的处理器，传感器 用于检测关于样本的信息，以及用于与用户通信的用户界面。
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公开(公告)号：US07687039B2
公开(公告)日：2010-03-30
申请号：US11295372
申请日：2005-12-05
CPC分类号： B01F13/0059 , B01F11/02 , B01F11/0283 , B01F13/0222 , B01F13/0277 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/0046 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L2400/0436 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
摘要： The present invention provides systems, methods, and devices for using acoustic energy.
摘要翻译： 本发明提供了用于使用声能的系统，方法和装置。
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公开(公告)号：US20090316520A1
公开(公告)日：2009-12-24
申请号：US12278311
申请日：2007-02-07
申请人： Mark Alan Barger , Parvinder Singh Walia , Matthew T. Bishop , Anthony Charles Neubauer , Joseph Dooley , Shih-yaw Lai , Luciana Rudolph
发明人： Mark Alan Barger , Parvinder Singh Walia , Matthew T. Bishop , Anthony Charles Neubauer , Joseph Dooley , Shih-yaw Lai , Luciana Rudolph
CPC分类号： G01N1/38 , B01F3/10 , B01F7/00258 , B01F11/0082 , B01F11/0085 , B01F15/00019 , B01F15/00058 , B01F15/0279 , B01F2015/0009 , B01F2015/00103 , B01J2219/00315 , B01J2219/00353 , B01J2219/0036 , B01J2219/00418 , B01J2219/00481 , B01J2219/00486 , G01N2011/0046
摘要： The invention is a device for processing materials comprising a mixing chamber having a valve for removal of the material from the mixing chamber and a piston which fits within the mixing chamber in a manner such that the piston can be moved to remove substantially all material from the mixing chamber via the valve; at least one, preferably at least two, retractable mixing element(s) wherein each of such elements is movable in and out of the mixing chamber through a port wherein the element and port are configured such that during mixing and when the element is withdrawn from the mixing chamber substantially no material is removed from the mixing chamber via the port. The invention is also a method of using such a device and a system comprising use of such devices in an automated or partially automated array.
摘要翻译： 本发明是用于处理材料的装置，其包括具有用于从混合室移除材料的阀的混合室和以这样的方式装配在混合室内的活塞，使得可以移动活塞以将基本上所有的材料从 混合室通过阀门; 至少一个，优选至少两个，可缩回的混合元件，其中每个这样的元件可以通过端口移动和移出混合室，其中元件和端口构造成使得在混合期间以及当元件从 混合室基本上没有材料通过端口从混合室中移出。 本发明还是一种使用这种装置和系统的方法，所述装置和系统包括在自动化或部分自动化的阵列中使用这种装置。
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公开(公告)号：US20080050289A1
公开(公告)日：2008-02-28
申请号：US11894655
申请日：2007-08-20
申请人： James Laugharn , Brevard Garrison
发明人： James Laugharn , Brevard Garrison
IPC分类号： B06B1/00
CPC分类号： B01F13/0277 , B01F11/02 , B01F11/0283 , B01F13/0059 , B01F13/0222 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J2219/00317 , B01J2219/00486 , B01J2219/00659 , C12M35/04 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
摘要： Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.
摘要翻译： 公开了用于通过选择性地控制声能和/或选择性地控制样品相对于声能的位置来处理样品的装置和方法。
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6.发明申请公开(公告)号：US20060029525A1
公开(公告)日：2006-02-09
申请号：US11167934
申请日：2005-06-27
申请人： James Laugharn , Brevard Garrison
发明人： James Laugharn , Brevard Garrison
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01F3/08 , B01F11/02 , B01F11/0283 , B01F13/0001 , B01F13/0059 , B01F13/02 , B01F13/0222 , B01F15/00123 , B01F15/00285 , B01F15/0201 , B01F2215/0037 , B01F2215/0073 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L7/52 , B01L2400/0433 , B01L2400/0436 , C40B60/14 , G10K15/00
摘要： Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.
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7.发明授权Method and apparatus for acoustically controlling liquid solutions in microfluidic devices 有权用于声学控制微流体装置中的液体溶液的方法和装置公开(公告)号：US06948843B2
公开(公告)日：2005-09-27
申请号：US09812723
申请日：2001-03-20
IPC分类号： B01F3/08 , B01F11/02 , B01F13/00 , B01F13/02 , B01F15/00 , B01F15/02 , B81B1/00 , C40B60/14 , B06B1/00
CPC分类号： B01J19/0046 , B01F3/08 , B01F11/02 , B01F11/0283 , B01F13/0001 , B01F13/0059 , B01F13/02 , B01F13/0222 , B01F15/00123 , B01F15/00285 , B01F15/0201 , B01F2215/0037 , B01F2215/0073 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L7/52 , B01L2400/0433 , B01L2400/0436 , C40B60/14 , G10K15/00
摘要： Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.
摘要翻译： 声能用于控制流体中的运动。 根据一个实施例，本发明将选定的天然存在的成核特征的声能引导以控制流体中的运动。 在另一个实施例中，本发明提供聚焦或未聚焦的声能以选择性地放置成核特征以控制流体运动。 根据一个实施例，本发明包括声源，用于控制声源的操作的控制器和位于要被控制的流体附近或之中的一个或多个成核特征。
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8.发明授权公开(公告)号：US09267867B2
公开(公告)日：2016-02-23
申请号：US12489693
申请日：2009-06-23
CPC分类号： G01N1/286 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N2035/00554
摘要： Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using an energy director positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
摘要翻译： 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件以减少和/或消除样品/气体界面处的顶部空间来控制其中声学处理样品的处理体积。 可以例如通过使用至少部分地定位在样品中的能量导向器来控制声能和样品之间的相互作用，这有助于减少否则将发生的飞溅或其它样品喷射。
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公开(公告)号：US20160002708A1
公开(公告)日：2016-01-07
申请号：US14856029
申请日：2015-09-16
申请人： Covaris, Inc.
CPC分类号： C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
摘要： This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
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公开(公告)号：US08353619B2
公开(公告)日：2013-01-15
申请号：US11888708
申请日：2007-08-01
IPC分类号： B01F11/00
CPC分类号： C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
摘要： This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
摘要翻译： 本发明涉及向样品施加声能的系统和方法。 根据本发明的一个方面，一种系统包括壳体，用于接收样品的腔室，用于根据治疗方案向样品提供聚焦声场的声能源，用于确定治疗方案的处理器，传感器 用于检测关于样本的信息，以及用于与用户通信的用户界面。
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