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公开(公告)号：US20150367302A1
公开(公告)日：2015-12-24
申请号：US14762862
申请日：2014-01-21
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus GEBAUER
IPC: B01F13/08
CPC classification number: B01F13/0818 , B01F7/00875 , B01F13/0845 , B01F13/089 , B01F15/0072 , B01F15/0085 , B01F2215/0032 , C12M27/02
Abstract: A magnetic agitator mixing system comprising: a first magnetic coupling part, a first driving means provided with a second magnetic coupling part, and a container which is substantially enclosing the first magnetic coupling part. The first magnetic coupling part is rotatably suspended in a stand, which is arranged to rest on an inner surface of the container and a first impeller is arranged to be driven by the first magnetic coupling part. The invention also relates to an agitator mixing stand.
Abstract translation: 一种磁性搅拌器混合系统，包括：第一磁耦合部分，设置有第二磁耦合部分的第一驱动装置和基本上包围第一磁耦合部分的容器。 第一磁耦合部分可旋转地悬挂在支架中，该支架被布置成搁置在容器的内表面上，并且第一叶轮布置成由第一磁耦合部分驱动。 本发明还涉及一种搅拌器混合机。
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2.发明授权Method and apparatus for stirring particles in suspension such as microcarriers for anchorage-dependent living cells in a liquid culture medium 失效用于在液体培养基中搅拌悬浮液中的颗粒，例如用于锚定依赖的活细胞的微载体的方法和装置
公开(公告)号：US4382685A
公开(公告)日：1983-05-10
申请号：US277403
申请日：1981-06-25
Applicant: James M. Pearson
Inventor： James M. Pearson
CPC classification number: C12M23/08 , B01F11/04 , B01F13/0827 , B01F13/089 , B01F7/30 , C12M25/16 , C12M27/02 , C12M27/20 , B01F7/00991
Abstract: Stirring apparatus for stirring particles in a liquid medium comprising a cylindrical stirring vessel having a stirring rod extending within the vessel to stir its contents. The rod has a bulbous tip which describes an orbital path in the vessel to sweep out an annular trough or channel formed in the bottom of the vessel. The annular trough or channel is contoured in section to follow the flow lines set up in the medium by secondary motion stirring effects. In this way accumulation of particles due to the secondary motion, which would otherwise occur at the corners and center of the bottom of the vessel, is avoided. The apparatus is advantageously useful in cell culture research particularly for stirring microcarriers in a liquid culture medium because it becomes possible to maintain the microcarriers in uniform suspension at lower stirring speeds than heretofore possible thus avoiding damage to the growing cells and improving overall cell yield.
Abstract translation: 用于在液体介质中搅拌颗粒的搅拌装置，其包括具有在容器内延伸的搅拌棒的圆柱形搅拌容器以搅拌其内容物。 杆具有球形尖端，其描述了容器中的轨道，以扫出形成在容器底部的环形槽或通道。 环形槽或通道的横截面是通过二次运动搅拌效应跟随在介质中设置的流动线。 以这种方式，避免了由于二次运动引起的颗粒的积聚，否则会在容器的底部的拐角和中心处发生。 该装置有利地用于细胞培养研究，特别是用于在液体培养基中搅拌微载体，因为可以在比以前更低的搅拌速度下将微载体保持在均匀悬浮液中，从而避免对生长细胞的损害并提高总细胞产量。
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公开(公告)号：US07892497B2
公开(公告)日：2011-02-22
申请号：US12063475
申请日：2006-08-10
Applicant: Masatoshi Shibata , Yutaka Mashiyama , Yasuyuki Suzuki , Isamu Hiruta , Toshiaki Wada , Tetsuo Tomoda
Inventor： Masatoshi Shibata , Yutaka Mashiyama , Yasuyuki Suzuki , Isamu Hiruta , Toshiaki Wada , Tetsuo Tomoda
CPC classification number: B01J19/0046 , B01F7/001 , B01F7/00116 , B01F7/00141 , B01F7/003 , B01F7/00558 , B01F13/0827 , B01F13/089 , B01J2219/00283 , B01J2219/00346 , B01J2219/00389 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0072
Abstract: To provide an organic synthesizer that can conduct a pressure reaction and an atmospheric reaction in one organic synthesizer and can realize attachment of reaction vessels to the organic synthesizer and detachment of the reaction vessels from the organic synthesizer without applying any load to gas supply/discharge pipes. An organic synthesizer comprising a reaction vessel support part (160), which can support two or more reaction vessels, and pressure regulation means (164) for regulating the pressure within the reaction vessel supported by the reaction vessel support part (160) by supplying/discharging gas. Two or more pressure regulation means (164) are provided for each reaction vessel supported by the reaction vessel support part (160). At least one pressure regulation means (164A) in the two or more pressure regulation means (164) is constructed so as to be detachable from and attachable to the other pressure regulation means (164B). The pressure regulation means (164) comprises gas supply/discharge pipes (174a to 174d) and openings (194a to 194d) for supporting the gas supply/discharge pipes (174a to 174d). The gas supply/discharge pipes (174a to 174d) are constructed so that a part near the front end can be flexed in a vertical direction and in a lateral direction and are connected to the supported reaction vessels for gas supply and discharge.
Abstract translation: 提供一种能够在一种有机合成仪中进行压力反应和大气反应的有机合成仪，并且可以实现反应容器与有机合成仪的连接，并使反应容器与有机合成仪分离，而不对气体供给/排出管施加任何负荷 。 一种有机合成装置，包括可支撑两个或更多个反应容器的反应容器支撑部分（160）和压力调节装置（164），用于调节由反应容器支撑部分（160）支撑的反应容器内的压力， 排气 为由反应容器支撑部分（160）支撑的每个反应容器提供两个或更多个压力调节装置（164）。 两个或更多个压力调节装置（164）中的至少一个压力调节装置（164A）构造成可拆卸并附接到另一压力调节装置（164B）。 压力调节装置（164）包括用于支撑供气/排放管（174a至174d）的气体供给排出管（174a至174d）和开口（194a至194d）。 气体供给排出管174a〜174d构成为能够使前端附近的部分在垂直方向和横向上弯曲并且与支撑的气体供给和排出的反应容器连接。
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公开(公告)号：US20090232712A1
公开(公告)日：2009-09-17
申请号：US12063475
申请日：2006-08-10
Applicant: Masatoshi Shibata , Yutaka Mashiyama , Yasuyuki Suzuki , Isamu Hiruta , Toshiaki Wada , Tetsuo Tomoda
Inventor： Masatoshi Shibata , Yutaka Mashiyama , Yasuyuki Suzuki , Isamu Hiruta , Toshiaki Wada , Tetsuo Tomoda
CPC classification number: B01J19/0046 , B01F7/001 , B01F7/00116 , B01F7/00141 , B01F7/003 , B01F7/00558 , B01F13/0827 , B01F13/089 , B01J2219/00283 , B01J2219/00346 , B01J2219/00389 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0072
Abstract: To provide an organic synthesizer that can conduct a pressure reaction and an atmospheric reaction in one organic synthesizer and can realize attachment of reaction vessels to the organic synthesizer and detachment of the reaction vessels from the organic synthesizer without applying any load to gas supply/discharge pipes.[MEANS FOR SOLVING PROBLEMS] An organic synthesizer comprising a reaction vessel support part (160), which can support two or more reaction vessels, and pressure regulation means (164) for regulating the pressure within the reaction vessel supported by the reaction vessel support part (160) by supplying/discharging gas. Two or more pressure regulation means (164) are provided for each reaction vessel supported by the reaction vessel support part (160). At least one pressure regulation means (164A) in the two or more pressure regulation means (164) is constructed so as to be detachable from and attachable to the other pressure regulation means (164B). The pressure regulation means (164) comprises gas supply/discharge pipes (174a to 174d) and openings (194a to 194d) for supporting the gas supply/discharge pipes (174a to 174d) The gas supply/discharge pipes (174a to 174d) are constructed so that a part near the front end can be flexed in a vertical direction and in a lateral direction and are connected to the supported reaction vessels for gas supply and discharge.
Abstract translation: 提供一种能够在一种有机合成仪中进行压力反应和大气反应的有机合成仪，并且可以实现反应容器与有机合成仪的连接，并使反应容器与有机合成仪分离，而不对气体供给/排出管施加任何负荷 。 解决问题的手段一种有机合成装置，包括可支撑两个或多个反应容器的反应容器支撑部分（160）和用于调节由反应容器支撑部分支撑的反应容器内的压力的压力调节装置（164） （160）通过供给/排出气体。 为由反应容器支撑部分（160）支撑的每个反应容器提供两个或更多个压力调节装置（164）。 两个或更多个压力调节装置（164）中的至少一个压力调节装置（164A）构造成可拆卸并附接到另一压力调节装置（164B）。 压力调节装置（164）包括用于支撑供气排放管（174a至174d）的气体供应/排放管（174a至174d）和开口（194a至194d）。供气/排放管（174a至174d） 构造成使得靠近前端的部分能够在垂直方向和横向方向上弯曲并且连接到用于供气和排出的支撑反应容器。
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公开(公告)号：US4649118A
公开(公告)日：1987-03-10
申请号：US597161
申请日：1984-04-05
Applicant: John A. Anderson
Inventor： John A. Anderson
CPC classification number: B01F13/089 , B01F11/04 , B01F13/0827 , C12M27/02 , C12M29/04
Abstract: A cell culturing apparatus having a unitary filter and stirring head suspended within a culture vessel by a flexible conduit which permits movement of the head in a predetermined nonrotary path for stirring the culture medium within the vessel while at the same time permitting filtering and removal of expended medium and culture byproducts by passage through the head and flexible conduit. The flexible conduit has an upper portion fixedly secured to the culture vessel so as to eliminate the necessity for rotary bearings and the like between relative moving parts, and the head carries a magnet which is movable by means of a magnetic drive located outside the culture vessel. In one embodiment, an auxiliary supply line is disposed within the flexible conduit and head to permit the introduction of fluids into the culture vessel simultaneously with the removal of expended medium therefrom.
Abstract translation: 一种细胞培养装置，其具有通过柔性导管悬挂在培养容器内的单一过滤器和搅拌头，其允许头部在预定的非旋转路径中移动以搅拌容器内的培养基，同时允许过滤和去除消耗的 介质和培养副产物通过头部和柔性导管。 柔性管道具有固定地固定在培养容器上的上部部分，以消除相对运动部件之间的旋转轴承等的必要性，并且头部承载可通过位于培养容器外侧的磁力驱动器移动的磁体 。 在一个实施例中，辅助供应管线设置在柔性管道和头部内，以允许将流体引入培养容器中同时从其中移出消耗的介质。
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Patent Agency Ranking
公开(公告)号：US3854704A
公开(公告)日：1974-12-17
申请号：US37908173
申请日：1973-07-13
Applicant: WHEATON INDUSTRIES
Inventor： BALAS J
CPC classification number: B01F13/089 , B01F11/04 , B01F13/0827 , C12M23/08 , C12M27/02
Abstract: This specification discloses several embodiments of the basic concept of providing a magnetic stirrer for a container of cells which is characterized by the inclusion of a magnet that is mounted on the lower end of a shaft which is mounted on or in a closure for an opening in the top of the container in such a manner that when magnetic forces are applied to the magnet from a rotating magnet external of the bottom of the container the magnet on the shaft is rotated, and, due either to the construction of the shaft which in most of the embodiments is flexible, or to its mounting on the closure, will move radially outwardly and upwardly in the container under the influence of the centrifugal force generated by its rotation. In the flexible shaft embodiments provision is made for adjusting the flexing amplitude of the shaft. Provision is also made for the introduction of a fluid, either gaseous or liquid, into the container through the closure and in addition to the culture or other material which is being stirred.
Abstract translation: 本说明书公开了提供用于电池容器的磁力搅拌器的基本概念的几个实施例，其特征在于包括安装在轴的下端上的磁体，该磁体安装在用于开口的开口中的封闭件上 容器的顶部，使得当磁力从容器底部的外部的旋转磁体施加到磁体上时，轴上的磁体被旋转，并且由于在大多数情况下的轴的结构 的实施例是柔性的或其在封闭件上的安装将在由其旋转产生的离心力的影响下在容器中径向向外和向上移动。 在柔性轴实施例中，设置了用于调节轴的弯曲振幅的装置。 还提供了通过封闭件以及正在搅拌的培养物或其它材料将气体或液体流体引入到容器中的装置。
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公开(公告)号：US20180221837A1
公开(公告)日：2018-08-09
申请号：US15424465
申请日：2017-02-03
Applicant: Michael John Ogilvie
Inventor： Michael John Ogilvie
CPC classification number: B01F13/089 , B01F7/1695 , B01F7/18 , B01F13/1013 , B01F15/00772
Abstract: An apparatus for mixing a liquid comprise a base having an associated head located thereover, an elongate stirring member extending between top and bottom ends along an axis, wherein the top end is magnetically coupled with the head so as to suspend the elongate stirring member therefrom and wherein the bottom end includes at least two arms radially extending therefrom, and a rotary motor located within the base magnetically coupled to the at least two arms so as to cause the elongate stirring member to rotate with the rotary motor. A method for locating the elongate stirring member within the container, placing the container on the base at a mixing location so as to magnetically couple the stirring member with the head; and turning the rotary motor so as to cause the elongate stirring member to rotate with the rotary motor.
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公开(公告)号：US09630157B2
公开(公告)日：2017-04-25
申请号：US14421837
申请日：2013-09-10
Applicant: TOP ELECTRIC APPLIANCES INDUSTRIAL LTD
Inventor： Weizhong Li , Yewu Zhong
CPC classification number: B01F7/1695 , A23C9/1524 , A47J43/0465 , B01F3/04439 , B01F3/04453 , B01F3/04808 , B01F13/0827 , B01F13/089 , B01F2015/00603 , B01F2215/0006
Abstract: Provided is a liquid stirring apparatus of the type using a non-contact drive mechanism (4) where the stirrer is driven through a magnetic drive effect without a mechanical connection member intruding through a wall of a container (2) for receiving a liquid to be stirred. The stirrer is received in use within the container (2). The non-connect driving mechanism (4) is arranged externally of the container (2). A holder is provided for positioning the stirrer within the container (2) where the holder is not integrally formed with the container (2), but is a separate component therefrom. The holder is not affixed to the container (2), but locates within the container (2) such that it positions the stirrer adjacent a wall of the container (2) near to the external location of the non-contact drive mechanism (4). The holder is manually removable from the container (2) and the stirrer is manually removable from the holder for cleaning.
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公开(公告)号：US20160033446A1
公开(公告)日：2016-02-04
申请号：US14810461
申请日：2015-07-27
Applicant: Schlumberger Technology Corporation
Inventor： Kay McGuinness , Nathan Scott Lawrence , Andrew Meredith , Andrew Warrillow , Laurent Pirolli
IPC: G01N27/404 , B01F11/02 , B01F13/08
CPC classification number: B01F13/0818 , B01F11/0048 , B01F11/0082 , B01F11/0266 , B01F13/089 , G01N27/4045 , G01N33/2823 , G01N33/2841
Abstract: Disclosed herein are devices and methods for the detection, quantification and/or monitoring of analytes. The systems and methods can be used, for example, to rapidly monitor gases downhole in a well.
Abstract translation: 本文公开了用于检测，定量和/或监测分析物的装置和方法。 这些系统和方法可用于例如在井中快速监测井下的气体。
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公开(公告)号：US3900186A
公开(公告)日：1975-08-19
申请号：US50522674
申请日：1974-09-12
Applicant: WHEATON INDUSTRIES
Inventor： BALAS JOHN THOMAS
CPC classification number: B01F13/089 , B01F11/04 , B01F13/0827 , C12M23/08 , C12M27/02
Abstract: This specification discloses several embodiments of the basic concept of providing a magnetic stirrer for a container of cells which is characterized by the inclusion of a magnet that is mounted on the lower end of a shaft which is mounted on or in a closure for an opening in the top of the container in such a manner that when magnetic forces are applied to the magnet from a rotating magnet external of the bottom of the container the magnet on the shaft is rotated, and, due either to the construction of the shaft which in most of the embodiments is flexible, or to its mounting on the closure, will move radially outwardly and upwardly in the container under the influence of the centrifugal force generated by its rotation. In the flexible shaft embodiments provision is made for adjusting the flexing amplitude of the shaft. Provision is also made for the introduction of a fluid, either gaseous or liquid, into the container through the closure and in addition to the culture or other material which is being stirred.
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