公开(公告)号：US20240358712A1

公开(公告)日：2024-10-31

申请号：US18767228

申请日：2024-07-09

申请人： WINSANTOR, INC.

发明人： Stanley Kim

IPC分类号： A61K31/5513 ,  A61P15/10

CPC分类号： A61K31/5513 ,  A61P15/10

摘要： The present disclosure generally relates to a method and topical composition for treating sensory problems associated with sexual function of subjects, or more specifically, disruptions to the sensory function of the anogenitals of subjects. In one embodiment, the present disclosure relates to a topical, transdermal or transmucosal formulation for improving anogenital sensory disorders wherein the formulation comprises pirenzepine.

公开(公告)号：US11802121B2

公开(公告)日：2023-10-31

申请号：US18049052

申请日：2022-10-24

申请人： Pfizer Inc.

发明人： Gary Erik Aspnes ,  Scott W. Bagley ,  John M. Curto ,  Matthew S. Dowling ,  David Edmonds ,  Mark E. Flanagan ,  Kentaro Futatsugi ,  David A. Griffith ,  Kim Huard ,  Gajendra Ingle ,  Wenhua Jiao ,  Chris Limberakis ,  Alan M. Mathiowetz ,  David W. Piotrowski ,  Roger B. Ruggeri

IPC分类号： A61K31/496 ,  A61K31/4545 ,  C07D401/14 ,  C07D487/04 ,  A61P3/00 ,  A61P15/10 ,  A61P17/06 ,  A61P9/10 ,  A61P19/06 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  A61P1/16 ,  A61P25/02 ,  A61P3/04 ,  A61P19/02 ,  A61P3/10 ,  A61P13/12 ,  A61P25/18 ,  A61P1/00 ,  A61P15/00 ,  A61P25/16 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P15/00 ,  A61P15/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P25/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

公开(公告)号：US20230165927A1

公开(公告)日：2023-06-01

申请号：US18100700

申请日：2023-01-24

申请人： ACTIV'INSIDE

发明人： David Gaudout ,  Stephane Rey ,  Benoit Lemaire ,  Benjamin Moras ,  Marion Dumoulin

IPC分类号： A61K36/88 ,  A61Q19/00 ,  A61K8/9794 ,  A61K8/9789 ,  A61P15/10 ,  A61P25/22 ,  A61P25/24 ,  A61K31/11

CPC分类号： A61K36/88 ,  A61Q19/00 ,  A61K8/9794 ,  A61K8/9789 ,  A61P15/10 ,  A61P25/22 ,  A61P25/24 ,  A61K31/11 ,  A61K2236/333 ,  A61K2236/35 ,  A61K2236/331 ,  A61K2236/33 ,  A61K2236/15

摘要： The invention concerns a plant extract obtained from saffron, with a safranal concentration, measured using the HPLC method, of a minimum of 0.2% in weight relative to the total dry matter weight. The invention also concerns a procedure for obtaining such an extract, as well as compositions including this extract, and its use.

公开(公告)号：US20190111098A1

公开(公告)日：2019-04-18

申请号：US16024869

申请日：2018-07-01

申请人： INFINITUS (CHINA) COMPANY LTD.

发明人： Fang LV ,  Hongwei ZHAO ,  Qingtao TANG

IPC分类号： A61K36/79 ,  A61K9/14 ,  A61K31/733 ,  A61K36/77 ,  A61K36/725 ,  A61K36/815 ,  A61K36/64 ,  A61K36/52 ,  A61K31/185 ,  A61K36/54 ,  A61K9/00 ,  A61P15/10 ,  A23L33/105 ,  B01D61/02 ,  A23P10/40

CPC分类号： A61K36/79 ,  A23K10/30 ,  A23L33/105 ,  A23P10/40 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/14 ,  A61K9/145 ,  A61K9/19 ,  A61K31/185 ,  A61K31/733 ,  A61K36/52 ,  A61K36/54 ,  A61K36/64 ,  A61K36/725 ,  A61K36/77 ,  A61K36/815 ,  A61K2236/331 ,  A61K2236/51 ,  A61P15/10 ,  B01D61/025 ,  A61K2300/00

摘要： The present disclosure relates to health care products, disclosing a powder formulation made from inulin, ARILLUS DIMOCARPUS LONGAN, FRUCTUS ZIZIPHUS JUJUBE, FRUCTUS LYCIUM BARBARUM, RADIX REHMANNIA GLUTINOSA PRAEPARATA, SEMEN JUGLANS REGIA, HERBA CISTANCHE TUBULOSA, taurine, FRUCTUS SCHISANDRA CHINENSIS and CORTEX CINNAMOMUM CASSIA, and a simple method for preparing the powder which is suitable for large-scale production. The powder of the present disclosure promotes the growth of experimental animals, enhances the sperm motility of the animals, improves the duration and frequency of sexual response, and increases the level of sex hormones and sexual organ coefficient ratio. The powder has an obvious function of improving sexual capacity, therefore can be used to prepare the health care foods having function on improving sexual capacity.

公开(公告)号：US20180250355A1

公开(公告)日：2018-09-06

申请号：US15446406

申请日：2017-03-01

申请人： Nymox Corporation

发明人： Paul Averback

IPC分类号： A61K38/10 ,  A61K45/06 ,  A61K9/00 ,  G09B7/10

CPC分类号： A61K38/10 ,  A61K9/0019 ,  A61K38/1716 ,  A61K45/06 ,  A61P15/10 ,  G09B7/10

摘要： The embodiments include methods of improving sexual function in a male with benign prostatic hyperplasia (BPH), using compositions containing compounds based on small peptides and a pharmaceutically acceptable carrier. The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intraprostatically, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier to a male in need thereof.

公开(公告)号：US20240216359A1

公开(公告)日：2024-07-04

申请号：US18600993

申请日：2024-03-11

申请人： GMP BIOTECHNOLOGY LIMITED

发明人： Vuong TRIEU

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61K31/10 ,  A61K31/7125 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  C12N15/113

CPC分类号： A61K31/485 ,  A61K9/0043 ,  A61K31/10 ,  A61K31/7125 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2320/31

摘要： This invention relates to methods, compositions and uses of medicaments for treating or ameliorating the symptoms of neurological disorders, such as Parkinson's Disease and Alzheimer's Disease. These purposes can be achieved with formulations of agents for inhibiting or suppressing expression of TGF-β, alone or in combination with formulations of agents based on apomorphine.

公开(公告)号：US20240174688A1

公开(公告)日：2024-05-30

申请号：US18481787

申请日：2023-10-05

申请人： Case Western Reserve University ,  Board of Regent of the University of Texas System

发明人： Sanford Markowitz ,  Joseph Ready ,  Yongyou Zhang ,  Monika Antczak ,  James K.V. Willson ,  Bruce Posner ,  William Greenlee

IPC分类号： C07D495/04 ,  A61K8/49 ,  A61K9/00 ,  A61K31/395 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/5377 ,  A61K35/28 ,  A61K38/19 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P7/06 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P15/10 ,  A61P17/00 ,  A61P17/02 ,  A61P17/14 ,  A61P19/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/04 ,  A61P37/06 ,  A61P39/00 ,  A61Q7/00 ,  A61Q19/04

CPC分类号： C07D495/04 ,  A61K8/49 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/395 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/5377 ,  A61K35/28 ,  A61K38/193 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P7/06 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P15/10 ,  A61P17/00 ,  A61P17/02 ,  A61P17/14 ,  A61P19/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/04 ,  A61P37/06 ,  A61P39/00 ,  A61Q7/00 ,  A61Q19/04 ,  Y02A50/30

摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

公开(公告)号：US11986506B2

公开(公告)日：2024-05-21

申请号：US16479798

申请日：2018-01-19

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Krishanu Senguptha ,  Venkata Krishna Raju Alluri

IPC分类号： A61K36/22 ,  A23L33/105 ,  A61K9/00 ,  A61K36/38 ,  A61K45/06 ,  A61P15/10

CPC分类号： A61K36/22 ,  A23L33/105 ,  A61K9/0095 ,  A61K36/38 ,  A61K45/06 ,  A61P15/10 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： The invention discloses synergistic compositions comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana for inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme or for increasing cGMP levels in a male subject. The invention further discloses a method of inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme, increasing cGMP levels and sexual arousal, treating/alleviating various aspects of male sexual dysfunction or impotence such as erectile dysfunction, loss of libido, or orgasm/ejaculation disorders in a male subject by using a suitable dose of synergistic composition comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana.

公开(公告)号：US20240034725A1

公开(公告)日：2024-02-01

申请号：US18477050

申请日：2023-09-28

申请人： Pfizer Inc.

发明人： Gary Erik Aspnes ,  Scott W. Bagley ,  John M. Curto ,  Matthew S. Dowling ,  David Edmonds ,  Mark E. Flanagan ,  Kentaro Futatsugi ,  David A. Griffith ,  Kim Huard ,  Gajendra Ingle ,  Wenhua Jiao ,  Chris Limberakis ,  Alan M. Mathiowetz ,  David W. Piotrowski ,  Roger B. Ruggeri

IPC分类号： C07D401/14 ,  A61K31/496 ,  A61K31/4545 ,  C07D487/04 ,  A61P3/00 ,  A61P15/10 ,  A61P17/06 ,  A61P9/10 ,  A61P19/06 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  A61P1/16 ,  A61P25/02 ,  A61P3/04 ,  A61P19/02 ,  A61P3/10 ,  A61P13/12 ,  A61P25/18 ,  A61P1/00 ,  A61P15/00 ,  A61P25/16 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/14 ,  A61K31/496 ,  A61K31/4545 ,  C07D487/04 ,  A61P3/00 ,  A61P15/10 ,  A61P17/06 ,  A61P9/10 ,  A61P19/06 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  A61P1/16 ,  A61P25/02 ,  A61P3/04 ,  A61P19/02 ,  A61P3/10 ,  A61P13/12 ,  A61P25/18 ,  A61P1/00 ,  A61P15/00 ,  A61P25/16 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

公开(公告)号：US11858943B2

公开(公告)日：2024-01-02

申请号：US17500780

申请日：2021-10-13

申请人： Neumora Therapeutics, Inc.

发明人： Robert M. Jones ,  Mariangela Urbano ,  Gary Brandt ,  David Hardick ,  Chris Knight ,  Jason Tierney

IPC分类号： C07D487/04 ,  A61P15/08 ,  A61P15/10 ,  A61P25/20 ,  C07D498/04 ,  A61P9/06 ,  A61P25/18 ,  A61P25/22 ,  C07D491/04 ,  A61P25/24

CPC分类号： C07D487/04 ,  A61P9/06 ,  A61P15/08 ,  A61P15/10 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  C07D491/04 ,  C07D498/04

摘要： Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:




wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.