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1.发明申请公开(公告)号：US20220356488A1
公开(公告)日：2022-11-10
申请号：US17738896
申请日：2022-05-06
摘要： A non-naturally occurring cell comprising an inoperative genomic asparaginase (Aspg) gene and an inoperative glutamine synthetase (Gs) gene, wherein the cell has been transfected with a controllably expressed gene encoding an enzyme having asparaginase activity, a controllably expressed gene encoding an enzyme having glutamine synthetase activity, and a controllably expressed gene encoding a heterologous protein of interest.
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公开(公告)号：US20220319794A1
公开(公告)日：2022-10-06
申请号：US17619686
申请日：2020-06-19
发明人： Tetsuya FUJITA , Takahiro SUZUKI , Yasuhide MIYAZAKI , Naoya KAWAI , Peter Uhd JEPSEN , Simon Lehnskov LANGE
摘要： An electron tube includes a housing that is internally held in a vacuum and has a window transmitting an electromagnetic wave, an electron emitting unit that is disposed in the housing and has a meta-surface emitting electrons in response to incidence of the electromagnetic wave, an electron multiplying unit that is disposed in the housing and multiplies the electrons emitted from the electron emitting unit, and an electron collecting unit that is disposed in the housing and collects the electrons multiplied by the electron multiplying unit. The window contains at least one selected from quartz, silicon, germanium, sapphire, zinc selenide, zinc sulfide, magnesium fluoride, lithium fluoride, barium fluoride, calcium fluoride, magnesium oxide, and calcium carbonate.
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公开(公告)号：US20220134047A1
公开(公告)日：2022-05-05
申请号：US17084275
申请日：2020-10-29
发明人： Marcus Carstensen , Paul Michael Petersen , Jes Broeng , Mark Henney , Ngoc Mai Nguyen , Robert Dobkin
摘要： Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.
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公开(公告)号：US11299782B2
公开(公告)日：2022-04-12
申请号：US16235247
申请日：2018-12-28
申请人： Children's Medical Center Corporation , The Technical University of Denmark , Dana-Farber Cancer Institute, Inc. , The Brigham and Women's Hospital, Inc.
发明人： Zoltan Szallasi , Nicolai Juul Birkbak , Aron Eklund , Daniel Silver , Zhigang Wang , Andrea Richardson
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6874 , C12Q1/6886
摘要： The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.
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公开(公告)号：US20190309373A1
公开(公告)日：2019-10-10
申请号：US16404204
申请日：2019-05-06
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , DANA-FARBER CANCER INSTITUTE, INC. , THE TECHNICAL UNIVERSITY OF DENMARK
IPC分类号： C12Q1/6886 , A61K31/704 , G01N33/574 , A61K33/24
摘要： The present invention provides assays, methods and systems for selecting an effective therapy for a subset of cancer patients having cancer cells with increased expression of BML and FANCI genes and/or having copy number increase in chromosome location 15q26 in the cancer cells and for treatment of such patients with the effective therapy of cancer patients based on the personalized cancer cell expression profile.
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公开(公告)号：US10190160B2
公开(公告)日：2019-01-29
申请号：US14466208
申请日：2014-08-22
申请人： Children's Medical Center Corporation , The Technical University of Denmark , Dana-Farber Cancer Institute, Inc. , The Brigham and Women's Hospital, Inc.
发明人： Zoltan Szallasi , Nicolai Juul Birkbak , Aron Eklund , Daniel Silver , Zhigang Wang , Andrea Richardson
IPC分类号： C12Q1/6886 , C12P19/34 , A61K38/00 , C07D487/00 , C12Q1/6874
摘要： The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.
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公开(公告)号：US10066245B2
公开(公告)日：2018-09-04
申请号：US14896897
申请日：2014-06-12
发明人： Niels Bjerg Jensen , Irina Borodina , Yun Chen , Jerome Maury , Kanchana Rueksomtawin Kildegaard , Jochen Förster , Jens Nielsen
摘要： A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
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公开(公告)号：US09917672B2
公开(公告)日：2018-03-13
申请号：US14909863
申请日：2014-08-11
IPC分类号： H04J14/04 , H04B10/2581 , H04J14/02 , H04B7/0413 , H04B7/06 , H04B10/2575
CPC分类号： H04J14/04 , H04B7/0413 , H04B7/0697 , H04B10/25753 , H04B10/2581 , H04J14/02
摘要： The present disclosure relates to system applications of multicore optical fibers. One embodiment relates to a base transceiver station for a wireless telecommunication system comprising a plurality of antenna units arranged in a MIMO configuration and adapted for transmission and/or reception of radio-frequency signals, an optical transmitter in the form of an electro-optic conversion unit for each of said plurality of antenna units, each electro-optic conversion unit adapted for converting an RF signal into an optical signal, a plurality of a single core optical fibers for guiding the optical signals, and at least one first space division multiplexing (SDM) unit adapted for multiplexing said single core optical fibers into respective individual cores of a multicore fiber, or into respective individual modes of a multimode fiber.
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公开(公告)号：US09658123B2
公开(公告)日：2017-05-23
申请号：US14896357
申请日：2014-06-04
CPC分类号： G01L9/0076 , G01L23/16 , H04R23/008 , H04R2201/003
摘要： The present invention relates to an all-optical pressure sensor comprising a waveguide accommodating a distributed Bragg reflector. Pressure sensing can then be provided by utilizing effective index modulation of the waveguide and detection of a wavelength shift of light reflected from the Bragg reflector. Sound sensing may also be provided thereby having an all-optical microphone. One embodiment of the invention relates to an optical pressure sensor comprising at least one outer membrane and a waveguide, the waveguide comprising at least one core for confining and guiding light, at least one distributed Bragg reflector located in said at least one core, and at least one inner deflecting element forming at least a part of the core, wherein the pressure sensor is configured such that the geometry and/or dimension of the at least one core is changed when the at least one outer membrane is submitted to pressure.
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公开(公告)号：US20160091421A1
公开(公告)日：2016-03-31
申请号：US14888391
申请日：2014-03-18
IPC分类号： G01N21/45
CPC分类号： G01N21/45 , G01N21/85 , G01N2201/0231
摘要： In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature, a chirp in the local spatial frequency of interference fringes of an interference pattern is reduced by mathematical manipulation of the recorded light intensity in the interference pattern or by the physical positioning and arrangement of a detector used for capturing the interference pattern.
摘要翻译： 在用于进行基于折射率的诸如化学成分或温度等流体性质的测量的方法中，干涉图案的干涉条纹的局部空间频率中的啁啾通过数学处理干涉中记录的光强度而被减少 图案或通过用于捕获干涉图案的检测器的物理定位和布置。
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