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1.发明公开公开(公告)号：US20240334924A1
公开(公告)日：2024-10-10
申请号：US18579616
申请日：2022-07-20
发明人： Takaya UCHIYAMA , Kuniya KOMAI , Tomonori INOUE
IPC分类号： A01N1/02 , C12Q1/6806
CPC分类号： A01N1/021 , A01N1/0242 , A01N1/0284 , C12Q1/6806
摘要： Provided is a storage solution for a cell-containing solution capable of suppressing leakage of genomic DNA to the outside of cells when a mixed solution of a cell-containing solution and a storage solution is stored under refrigeration. A storage solution for a cell-containing solution according to the present invention contains a formaldehyde donor compound (A) and a compound (B) that is an inorganic salt, an organic acid, or an organic salt, an electrical conductivity of the storage solution being 3 ms/cm or more and 20 ms/cm or less.
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2.发明公开公开(公告)号：US20240319206A1
公开(公告)日：2024-09-26
申请号：US18579203
申请日：2022-07-14
发明人： Kengo FUJIMURA , Ryuta SASAKI
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , G01N2333/521
摘要： An object is to provide a diluent for a calibration sample and a sample that is less likely to cause a carryover of the TARC antigen. The object can be solved by a composition including (A) TARC (Thymus and activation-regulated chemokine) and (B) one or more components selected from the group consisting of acidic amino acids, basic amino acids, acidic polymers having an average molecular weight of 4,000 to 1,200,000, and salts thereof, and being in liquid form.
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公开(公告)号：US20240245844A1
公开(公告)日：2024-07-25
申请号：US18564326
申请日：2022-05-27
发明人： Kuniya KOMAI , Takaya UCHIYAMA , Marika KANDA , Tomonori INOUE
CPC分类号： A61M1/3693 , A61J1/05
摘要： Provided is a blood collection container capable of suppressing contamination of plasma by white blood cells and components in white blood cells. A blood collection container according to the present invention includes a blood collection container main body, a plasma separation material stored in the blood collection container main body, and an aqueous solution stored in the blood collection container main body, in which a solute contained in the aqueous solution contains an anticoagulant, and a total concentration of the solute in the aqueous solution is 100 mM or more and 450 mM or less, or 1200 mM or more.
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公开(公告)号：US20230358767A1
公开(公告)日：2023-11-09
申请号：US18025813
申请日：2021-09-10
发明人： Satoshi MACHIDA , Hiroki OSAKO , Kouji YAMAMOTO , Yuuri HAYAKAWA
CPC分类号： G01N33/725 , C12P3/00 , C07C49/86 , G01N2333/908
摘要： An object of the present invention is to provide a method for measuring an object to be measured in a specimen by an enzymatic method, the measurement method being able to suppress the positive influence of peroxide derived from the specimen. More specifically, an object of the present invention is to provide a measurement method and a measurement reagent that can suppress elevation in value regardless of whether or not the specimen is a catalase-free specimen. Provided is a measurement method that can accurately quantify hydrogen peroxide derived from an object to be measured, without influence derived from a specimen, by contacting the specimen with an enzyme in the presence of at least one compound selected from the group consisting of a compound represented by the following general formula (I), a benzimidazole derivative having an electron-donating substituent at position 2, and histidine, wherein R1 and R2 are the same or different and each represent hydrogen, a linear or branched alkyl group having 1 to 6 carbon atoms and optionally having a substituent, an aryl group optionally having a substituent, or an alkyloxy group having 1 to 6 carbon atoms.
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公开(公告)号：US20230341371A1
公开(公告)日：2023-10-26
申请号：US17998876
申请日：2021-07-15
发明人： Toshiki KAWABE , Yukio ODA
IPC分类号： G01N33/49
CPC分类号： G01N33/4905
摘要： Provided is a blood analysis method including: acquiring coagulation reaction data on a blood specimen; calculating a parameter related to a centroid point from a differential curve of the coagulation reaction data; and evaluating coagulation properties of the blood specimen using the parameter related to the centroid point.
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公开(公告)号：US20230266337A1
公开(公告)日：2023-08-24
申请号：US18015210
申请日：2021-07-09
发明人： Akiko MATSUMOTO , Tomoyuki USUI , Yuka SUZUKI , Kengo FUJIMURA
IPC分类号： G01N33/68
CPC分类号： G01N33/6863
摘要： An object of the present invention is to provide a TARC-containing composition with high storage stability. Provided is a composition including TARC (Thymus and activation-regulated chemokine) and one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant and being in liquid form. The aforementioned object is achieved by the composition.
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7.发明申请公开(公告)号：US20230118882A1
公开(公告)日：2023-04-20
申请号：US17914044
申请日：2021-03-24
发明人： Maasa YAJI , Yuya INABA , Shinichiro KITAHARA , Takeshi WAKIYA , Mai YAMAGAMI , Shuhei OBINATA
IPC分类号： G01N33/553
摘要： Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer disposed on the core particle, the magnetic layer containing microparticles of a magnetic metal and/or an oxide thereof; and a substance that specifically interacts with an analyte, the substance being supported on the magnetic responsive particle, wherein, assuming that a volume and a weight of the core particle are respectively vc and wc, and that a volume and a weight of the magnetic responsive particle are respectively ve and we, the magnetic material density [(we−wc)/(ve−vc)] satisfies the following expression 1: 2.0≤(we−wc)/(ve−vc) Expression 1 The magnetic responsive particle has a high magnetic collection property in spite of a small particle size. When the magnetic responsive particle is used, a reagent for an immunoassay having excellent magnetic separability and capable of realizing high sensitivity can be provided.
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公开(公告)号：US20220386913A1
公开(公告)日：2022-12-08
申请号：US17775461
申请日：2020-12-02
发明人： Kuniya KOMAI
IPC分类号： A61B5/15
摘要： There is provided a blood collection container capable of suppressing the contamination of white blood cells into blood plasma. A blood collection container according to the present invention is a blood collection container into which a predetermined amount of blood is collected. The blood collection container includes a blood collection container main body, and a blood plasma separation material, an osmotic pressure regulator, and an anticoagulant contained in the blood collection container main body. The specific gravity of the blood plasma separation material at 25° C. is 1.030 or more and 1.120 or less. When the osmotic pressure regulator and the anticoagulant contained in the blood collection container main body are dissolved in an amount of physiological saline solution equivalent to a predetermined amount of blood collected in the blood collection container to obtain an osmotic pressure measurement solution, the specific gravity of the blood plasma separation material at 25° C. and the osmotic pressure of the osmotic pressure measurement solution satisfy a specific relationship.
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公开(公告)号：US11471843B2
公开(公告)日：2022-10-18
申请号：US16911392
申请日：2020-06-25
发明人： Toshiki Kawabe
IPC分类号： G01J3/04 , B01F33/452 , G01N35/10 , G01N1/28 , B01F101/23
摘要： A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.
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公开(公告)号：US20220326262A1
公开(公告)日：2022-10-13
申请号：US17606274
申请日：2020-04-23
发明人： Toshiki KAWABE , Yukio ODA , Mari EMMI , Midori SHIMA , Keiji NOGAMI , Kenichi OGIWARA , Naruto SHIMONISHI
摘要： Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.
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