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    OPTICAL FILTER DEVICE, SYSTEM, AND METHOD FOR IMPROVED OPTICAL REJECTION OF OUT-OF-BAND WAVELENGTHS
    3.
    发明申请
    OPTICAL FILTER DEVICE, SYSTEM, AND METHOD FOR IMPROVED OPTICAL REJECTION OF OUT-OF-BAND WAVELENGTHS 有权

    公开(公告)号：US20220160263A1

    公开(公告)日：2022-05-26

    申请号：US17669828

    申请日：2022-02-11

    Applicant: Profusa, Inc.

    Inventor： Clayton LEPAK

    IPC: A61B5/1459 ,  G02B5/20

    Abstract: An optical filter device, system, and method for improved optical rejection of out-of-band wavelengths is disclosed. For example, an analyte detection system is provided that includes an excitation light source for illuminating an implantable sensor and an optical detector for collecting emission light from the implantable sensor. Further, the analyte detection system includes an optical filter device arranged between the implantable sensor and the optical detector, wherein the optical filter device provides high optical rejection of out-of-band wavelengths of the emission light.

    Method and system for directing a localized biological response to an implant
    5.
    发明授权
    Method and system for directing a localized biological response to an implant 有权

    公开(公告)号：US10583308B2

    公开(公告)日：2020-03-10

    申请号：US15376147

    申请日：2016-12-12

    Applicant: Profusa, Inc.

    Inventor： William A. McMillan ,  Natalie Wisniewski

    IPC: A61M35/00 ,  A61N5/06 ,  A61B5/145 ,  A61K9/70 ,  A61B5/1459 ,  A61M5/142 ,  A61M11/00 ,  A61M37/00 ,  A61K9/00 ,  A61N5/067

    Abstract: The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.

    Method and device for correcting optical signals
    9.
    发明授权
    Method and device for correcting optical signals 有权

    公开(公告)号：US12059254B2

    公开(公告)日：2024-08-13

    申请号：US17493451

    申请日：2021-10-04

    Applicant: Profusa, Inc.

    Inventor： Gregory J. Kintz ,  William McMillan ,  Natalie Wisniewski

    IPC: A61B5/1459 ,  A61B5/00 ,  A61B5/145

    CPC classification number: A61B5/1459 ,  A61B5/14532 ,  A61B5/7203

    Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

    METHOD AND SYSTEM FOR IN VITRO SENSING OF ANALYTES
    10.
    发明申请
    METHOD AND SYSTEM FOR IN VITRO SENSING OF ANALYTES 有权

    公开(公告)号：US20230044094A1

    公开(公告)日：2023-02-09

    申请号：US17970339

    申请日：2022-10-20

    Applicant: Profusa, Inc.

    Inventor： Ben HWANG ,  Soya GAMSEY

    IPC: A61B5/145 ,  G01N21/77 ,  G01N33/53

    Abstract: Some embodiments described herein relate to a method that includes receiving an optical emission signal from a sensor disposed in a vessel. The vessel can be configured for an in vitro biological process (e.g., a bioreactor), and the emission signal can be received while the sensor is in contact with a biological matrix. The emission signal can be received by a reader that is disposed outside the vessel. At least one of a presence, quantity, or concentration of an analyte can be determined based on the emission signal. Similarly stated, the emission signal emitted by the sensor can be dependent on at least one of a presence, quantity, or concentration of the analyte. In some embodiments, the emission signal can be an optical signal emitted by a sensor in response to the sensor being excited by an excitation optical signal emitted by, for example, the reader.

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