公开(公告)号：US20100310537A1

公开(公告)日：2010-12-09

申请号：US12746507

申请日：2008-12-05

申请人： Takanori Nakamura ,  Atsushi Miyamura ,  Taito Nishino ,  Norihisa Ishiwata ,  Katsuaki Miyaji

发明人： Takanori Nakamura ,  Atsushi Miyamura ,  Taito Nishino ,  Norihisa Ishiwata ,  Katsuaki Miyaji

IPC分类号： A61K35/12 ,  C12N5/078 ,  A61P37/00 ,  A61P35/00 ,  A61P7/00 ,  A61P9/10 ,  A61P35/02

CPC分类号： C12N5/0647 ,  A61K35/12 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/999

摘要： An object of the present invention is to expand CD34+ cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34+ cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells.A method for expanding CD34+ cells, which comprises culturing CD34+ cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L1, L2, L3, L4, R1, R2, R3, X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

公开(公告)号：US20070155897A1

公开(公告)日：2007-07-05

申请号：US10583559

申请日：2004-12-17

申请人： Yoshihiro Tani ,  Kenichi Motoyama

发明人： Yoshihiro Tani ,  Kenichi Motoyama

IPC分类号： B05D3/02 ,  C08K3/22 ,  B60C1/00 ,  C08G77/06

CPC分类号： C08G77/50 ,  C09D5/1675 ,  C09D183/14

摘要： To provide a process for forming an improved coating film on a substrate, particularly to provide a coating film formed on a substrate, as adhered to the surface of the substrate, having a refractive index of from 1.28 to 1.38 and a contact angle with water of from 90° to 115°. A coating film having a refractive index of from 1.28 to 1.38 and a contact angle with water of from 90° to 115°, which is formed as adhered to a substrate surface by forming a reaction mixture comprising a silicon compound (A) of the formula Si(OR)4, a silicon compound (B) of the formula (R1O)3SiCH2CH2(CF2)nCH2CH2Si(OR1)3, an alcohol (C) of the formula R2CH2OH, and oxalic acid (D), in a specific ratio; heating this reaction mixture at a temperature of from 50 to 180° C. in the absence of water, to form a solution of a polysiloxane; then applying a coating fluid comprising the polysiloxane solution on a substrate surface to form a coating; and heat-curing the coating at a temperature of from 80 to 450° C.; a method for forming such a coating film; and a process for producing such a coating fluid.

摘要翻译： 为了提供一种在基材上形成改进的涂膜的方法，特别是提供一种形成在基材上的涂膜，粘合到基材表面上，折射率为1.28-1.38，与水的接触角为 从90°到115°。 1.一种涂膜，其折射率为1.28〜1.38，与水的接触角为90〜115°，通过形成含有式（I）的硅化合物（A） Si（OR）4 S，式（R 1 O 2）3 SiCH 2的硅化合物（B）3 （CH 2）2 CH 2（OR 2）2（CH 2）2 CH 2 3，将式R 2 CH 2 OH的醇（C）和草酸（ D），具体比例; 在不存在水的情况下，在50〜180℃的温度下加热该反应混合物，形成聚硅氧烷溶液; 然后将包含所述聚硅氧烷溶液的涂布液涂布在基材表面上以形成涂层; 并在80至450℃的温度下热固化涂层; 形成这种涂膜的方法; 以及这种涂布液的制造方法。

公开(公告)号：US20020095013A1

公开(公告)日：2002-07-18

申请号：US09991649

申请日：2001-11-26

申请人： Nissan Chemical Industries Limited

发明人： Poopathy Kathirgamanathan ,  Subramaniam Ganeshamurugan

IPC分类号： C08G069/00

CPC分类号： C08G73/026 ,  Y10T428/31551

摘要： A method of production of a homopolymer or copolymer or homo-oligomer or co-oligomer product characterised in that the product is obtained by condensation reaction of a diaminoanthracene, substituted or not, optionally with a diiminoanthracene substituted or not in the absence of anthraquinone substituted or not.

摘要翻译： 制备均聚物或共聚物或均聚低聚物或共低聚物产物的方法，其特征在于产物是通过二氨基蒽的缩合反应获得的，所述二氨基蒽被取代或未被任选取代或未被取代或不与蒽醌取代或取代的二亚氨基蒽 不。

公开(公告)号：US4247480A

公开(公告)日：1981-01-27

申请号：US65338

申请日：1979-08-09

申请人： Atsuo Murata ,  Syuji Tsuchiya ,  Akihiro Konno ,  Fumiyoshi Arima ,  Hisao Ikeda

发明人： Atsuo Murata ,  Syuji Tsuchiya ,  Akihiro Konno ,  Fumiyoshi Arima ,  Hisao Ikeda

IPC分类号： C07B61/00 ,  B01J27/00 ,  C07C291/04 ,  C07C135/02

CPC分类号： C07C291/04

摘要： An amine oxide is produced by oxidizing a tertiary amine having the formula ##STR1## wherein R.sub.1 and R.sub.2 respectively represent methyl or ethyl group; and R.sub.3 represent a C.sub.8 -C.sub.14 alkyl or alkenyl group in the presence of carbon dioxide and in the presence or absence of an improver selected from the group consisting of ethylenediaminetetraacetic acid, its salts, stanates, polyphosphates, salts of hydroxycaboxylic acid and salts of polycarboxylic acid.

摘要翻译： 通过氧化具有式“IMAGE”的叔胺制备氧化胺，其中R1和R2分别表示甲基或乙基; 并且R 3在二氧化碳的存在下和在存在或不存在选自乙二胺四乙酸，其盐，甾烷酸酯，多磷酸盐，羟基羧酸的盐和多元羧酸盐的存在或不存在的情况下代表C 8 -C 14烷基或烯基 酸。

公开(公告)号：US4208391A

公开(公告)日：1980-06-17

申请号：US933582

申请日：1978-08-14

申请人： Makoto Endo ,  Kohji Kusahara

发明人： Makoto Endo ,  Kohji Kusahara

IPC分类号： C01B21/50 ,  B01D53/56 ,  C01F11/00 ,  C04B22/08 ,  C23F11/18 ,  C01B21/20

CPC分类号： C23F11/181 ,  B01D53/56 ,  C01F11/00 ,  C04B22/085

摘要： An aqueous solution of calcium nitrite having high purity and high concentration is obtained by contacting a nitrogen oxides containing gas with an aqueous slurry of calcium hydroxide.It is necessary to use the aqueous slurry having high calcium hydroxide content such as 20 to 40 wt. %, whereby it is necessary to feed the gas having high nitrogen oxides concentration such as 5 to 10 vol. % to give high conversion to calcium nitrite. In order to prevent a formation of a by-product of calcium nitrate, a nitrogen oxides containing gas having 5 to 10 vol. % of a nitrogen oxides concentration and 1.2 to 1.5 of a molar ratio of NO/NO.sub.2 is fed as a first stage and then, the unabsorbed gas is oxidized and the resulting gas having 1 to 3 vol. % of a nitrogen oxides concentration and 1.2 to 1.5 of molar ratio of NO/NO.sub.2 is fed to the aqueous slurry having 3 to 10 wt. % of a calcium hydroxide obtained in the first stage so as to convert the residual calcium hydroxide to calcium nitrite without forming a by-product of calcium nitrate. The process is preferably carried out as continuous process having a first reaction zone and a second reaction zone.

摘要翻译： 通过使含有氮氧化物的气体与氢氧化钙的水性浆液接触，可以获得高纯度和高浓度的亚硝酸钙水溶液。 需要使用氢氧化钙含量高的含水浆料，例如20〜40重量％ ％，因此有必要将具有高的氮氧化物浓度的气体例如5〜10体积份。 ％以提供高亚硝酸钙转化率。 为了防止硝酸钙的副产物的形成，含有5〜10体积％ 氮氧化物浓度的％和NO1 / NO2的摩尔比为1.2〜1.5作为第一阶段进料，然后，未吸收的气体被氧化，得到的气体具有1〜3体积％ 将氮氧化物浓度的％和NO1 / NO2的摩尔比为1.2〜1.5进料到含有3〜10重量％ 在第一阶段获得的氢氧化钙的百分比，以便将残留的氢氧化钙转化成亚硝酸钙而不形成硝酸钙的副产物。 该方法优选作为具有第一反应区和第二反应区的连续方法进行。

公开(公告)号：US20100312000A1

公开(公告)日：2010-12-09

申请号：US12867339

申请日：2009-02-27

申请人： Satoshi Nakano ,  Daisuke Saito

发明人： Satoshi Nakano ,  Daisuke Saito

IPC分类号： C07C331/30 ,  C07C331/28 ,  C07C331/24 ,  C07C331/20

CPC分类号： C07C331/20 ,  C07C331/24 ,  C07C331/28 ,  C07C331/30 ,  C07C2601/14

摘要： To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s).A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.

摘要翻译： 提供从具有羧基的相应氨基化合物制备具有羧基的异硫氰酸酯化合物的新方法。 一种具有羧基并由式（2）表示的异硫氰酸酯化合物的制备方法。 该方法包括使具有羧基的氨基化合物与由式（1）表示的氨基化合物反应（其中A为例如C 6-14芳族烃基或C 1-12饱和烃基，B为例如 单键，C6-14芳族烃基或C1-12饱和烃基）在溶剂中与二硫化碳（CS2）反应，然后以卤素作为单一物质。

公开(公告)号：US20020111485A1

公开(公告)日：2002-08-15

申请号：US10118260

申请日：2002-04-09

申请人： Nissan Chemical Industries Limited

发明人： Hisao Ikeda ,  Motohiko Hidaka ,  Atsumi Aoki

IPC分类号： C07D47/14

CPC分类号： C07D405/14

摘要： Optically active null-type tris-(2,3-epoxypropyl)-isocyanurate is obtained by a method of reacting isocyanuric acid with an optically active epihalohydrin, or a method of optically resolving a racemic modification of tris-(2,3-epoxypropyl)-isocyanurate by using an amylose or cellulose derivative. It is a method for producing a high melting point type tris-(2,3-epoxypropyl)-isocyanurate obtained by mixing two enantiomers of optically active null-type tris-(2,3-epoxypropyl)-isocyanurate.

公开(公告)号：US4186148A

公开(公告)日：1980-01-29

申请号：US902758

申请日：1978-05-03

申请人： Atsuo Murata ,  Shuji Tsuchiya ,  Akihiro Konno ,  Jun Uchida

发明人： Atsuo Murata ,  Shuji Tsuchiya ,  Akihiro Konno ,  Jun Uchida

IPC分类号： C07B61/00 ,  B01J31/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/60 ,  C07C211/21 ,  C07C85/18 ,  C07D295/02

CPC分类号： C07C209/60

摘要： 3,7-Dimethyl-2,6-octadienylamine derivatives are produced by reacting isoprene with a secondary amine in the presence of a catalyst prepared by reacting a secondary amine, a conjugated diene and/or a polycyclic aromatic compound, a lithium salt and sodium and/or potassium metal.

摘要翻译： 3,7-二甲基-2,6-辛二烯基胺衍生物通过使异戊二烯与仲胺反应，在通过使仲胺，共轭二烯和/或多环芳族化合物，锂盐和钠 和/或钾金属。

公开(公告)号：US20140051857A1

公开(公告)日：2014-02-20

申请号：US14064367

申请日：2013-10-28

申请人： Nissan Chemical Industries Limited

发明人： Shingo OWADA ,  Shunsuke Iwamoto ,  Kazufumi Yanagihara ,  Katsuaki Miyaji ,  Takanori Nakamura ,  Norihisa Ishiwata ,  Yutaka Hirokawa

IPC分类号： C07D417/12 ,  C07D295/192 ,  C07D403/12 ,  C07D231/18 ,  C07D333/32

CPC分类号： C07D417/12 ,  C07D231/18 ,  C07D295/192 ,  C07D333/32 ,  C07D333/38 ,  C07D403/12 ,  C07D409/12

摘要： A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

摘要翻译： 由式（1）表示的化合物：其中A是氮原子或CR 4，B是氧原子，硫原子或NR 9（条件是当A是氮原子时，B不是NH），R1是C2 -14芳基，L1为键，CR10R11，氧原子，硫原子或NR12，X为OR13，SR13或NR14NR15，R2为氢原子，甲酰基，C1-10烷基等， L2是键或类似物，L3是键，CR17R18，氧原子，硫原子或NR19，L4是键，CR20R21，氧原子，硫原子或NR22，Y是氧原子，硫 原子或NR 23，并且R 3是该化合物或其溶剂合物的C2-14芳基，互变异构体，前药或药学上可接受的盐。

公开(公告)号：US20140023798A1

公开(公告)日：2014-01-23

申请号：US14038204

申请日：2013-09-26

申请人： Nissan Chemical Industries Limited

发明人： Kimiaki Tsutsui ,  Takahiro Sakai ,  Kohei Goto

IPC分类号： G02F1/1337

CPC分类号： G02F1/133723 ,  C08G73/10 ,  C09K19/56 ,  Y10T428/1023

摘要： To provide a liquid crystal aligning agent useful to obtain a liquid crystal alignment film excellent in liquid crystal alignment properties, alignment controlling power and rubbing resistance, having high voltage retention characteristics and having reduced charge accumulation, and a liquid crystal display device which is less susceptible to display failure, to lowering of contrast or to image persistence.A liquid crystal aligning agent comprising a low resistance polyimide precursor having a volume resistivity of from 1×1010 to 1×1014 Ωcm when formed into a film, and a high alignment polyimide precursor or polyimide having a specific structure, and a liquid crystal display device employing this liquid crystal aligning agent.

摘要翻译： 提供一种液晶取向剂，其具有优异的液晶取向性，取向控制功率和耐摩擦性，具有高电压保持特性并且具有降低的电荷积聚的液晶取向膜，以及易受影响的液晶显示装置 显示失败，降低对比度或图像持久性。 一种液晶取向剂，其包含形成膜时体积电阻率为1×10 10〜1×10 14Ω·mol的低电阻聚酰亚胺前体，以及具有特定结构的高取向聚酰亚胺前体或聚酰亚胺以及液晶显示装置 采用该液晶取向剂。