公开(公告)号：US20140051857A1

公开(公告)日：2014-02-20

申请号：US14064367

申请日：2013-10-28

申请人： Nissan Chemical Industries Limited

发明人： Shingo OWADA ,  Shunsuke Iwamoto ,  Kazufumi Yanagihara ,  Katsuaki Miyaji ,  Takanori Nakamura ,  Norihisa Ishiwata ,  Yutaka Hirokawa

IPC分类号： C07D417/12 ,  C07D295/192 ,  C07D403/12 ,  C07D231/18 ,  C07D333/32

CPC分类号： C07D417/12 ,  C07D231/18 ,  C07D295/192 ,  C07D333/32 ,  C07D333/38 ,  C07D403/12 ,  C07D409/12

摘要： A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

摘要翻译： 由式（1）表示的化合物：其中A是氮原子或CR 4，B是氧原子，硫原子或NR 9（条件是当A是氮原子时，B不是NH），R1是C2 -14芳基，L1为键，CR10R11，氧原子，硫原子或NR12，X为OR13，SR13或NR14NR15，R2为氢原子，甲酰基，C1-10烷基等， L2是键或类似物，L3是键，CR17R18，氧原子，硫原子或NR19，L4是键，CR20R21，氧原子，硫原子或NR22，Y是氧原子，硫 原子或NR 23，并且R 3是该化合物或其溶剂合物的C2-14芳基，互变异构体，前药或药学上可接受的盐。