公开(公告)号：US20240268968A1

公开(公告)日：2024-08-15

申请号：US18581570

申请日：2024-02-20

Applicant: MUSC Foundation for Research Development

Inventor： Stephen Kalhorn ,  Mark E. Semler ,  Joseph Ruscito ,  Christopher Hapstack

IPC: A61F2/44 ,  A61F2/30 ,  A61F2/46

CPC classification number: A61F2/4455 ,  A61F2/4611 ,  A61F2002/30471 ,  A61F2002/3055 ,  A61F2002/30556 ,  A61F2002/30884 ,  A61F2002/30891 ,  A61F2002/4415 ,  A61F2002/4445 ,  A61F2002/4698

Abstract: The present invention provides expandable devices and insertion tools for deploying the expandable devices. The expandable devices are capable of increasing in height and width when expanded from a closed configuration to an open configuration to occupy a larger volume and to present a larger surface area. The expandable devices are lockable and are capable of rigidly occupying a space after expansion. In some embodiments, the expandable devices are useful as interbody devices for spinal fusions.

公开(公告)号：US11963980B2

公开(公告)日：2024-04-23

申请号：US16095828

申请日：2017-04-25

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Chrystal M. Paulos ,  Michelle H. Nelson ,  Stefanie R. Bailey

IPC: A61K35/17 ,  A61K38/19 ,  A61K39/00 ,  A61P35/00 ,  C12N5/0783 ,  C12N5/16

CPC classification number: A61K35/17 ,  A61K38/19 ,  A61K39/0011 ,  A61K39/001156 ,  A61K39/001168 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/163 ,  A61K2039/5156 ,  A61K2039/5158 ,  C12N2510/00 ,  G01N2800/52

Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.

公开(公告)号：US20240085427A1

公开(公告)日：2024-03-14

申请号：US18259640

申请日：2022-01-04

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Nathan G. DOLLOFF ,  Reeder M. ROBINSON

IPC: G01N33/574 ,  C07K16/28

CPC classification number: G01N33/57488 ,  C07K16/283 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/94 ,  G01N2333/99

Abstract: The present disclosure is directed to antibodies binding to AGR2 and cancer cells that express or overexpress AGR2, and methods for use thereof.

公开(公告)号：US20230399387A1

公开(公告)日：2023-12-14

申请号：US18033464

申请日：2021-11-05

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Federica DEL MONTE ,  Rakez KAYED

IPC: C07K16/18 ,  G01N33/68 ,  A61P9/00

CPC classification number: C07K16/18 ,  G01N33/6896 ,  A61P9/00 ,  C07K2317/31 ,  G01N2800/32

Abstract: The present disclosure is directed to method of diagnosing and treating heart disease using antibodies that bind to Cofilin, Aβ and/or Tau.

公开(公告)号：US20230389853A1

公开(公告)日：2023-12-07

申请号：US18449091

申请日：2023-08-14

Applicant: MUSC Foundation for Research Development

Inventor： Nancey Trevanian Tsai ,  Mark E. Semler

IPC: A61B5/00 ,  A61B5/16 ,  G16H40/67 ,  G16H50/20 ,  G16H20/70 ,  A61B5/11

CPC classification number: A61B5/4076 ,  A61B5/163 ,  G16H40/67 ,  G16H50/20 ,  G16H20/70 ,  A61B5/0077 ,  A61B5/1104 ,  A61B5/162 ,  A61B5/743 ,  A61B5/7475

Abstract: A device for measuring eyelid movement in a human subject comprises a housing, at least one stimulator mounted to the housing, and a camera. The at least one stimulator is configured to provide stimulus to one or both eyes of the subject. The camera is configured to collect information related to movement of one or both eyes of the subject. The device also includes a user interface that is configured to control the at least one stimulator and display information collected by the camera.

公开(公告)号：US11690549B2

公开(公告)日：2023-07-04

申请号：US17158620

申请日：2021-01-26

Applicant: MUSC Foundation for Research Development

Inventor： Jonathan Edwards ,  Jessica Barley ,  Mark Semler

IPC: A61B5/24 ,  A61B5/00 ,  A61B5/296

CPC classification number: A61B5/24 ,  A61B5/0022 ,  A61B5/296 ,  A61B5/688 ,  A61B5/6849 ,  A61B5/7203 ,  A61B2505/05

Abstract: A needle electrode fixation device is configured to secure a transdermal needle electrode to a patient. The device includes a base having a body that defines a first portion and a second portion. The first and second portions are rotatable relative to each other. The first portion defines a channel configured to fit a portion of the transdermal needle electrode. The second portion defines a recess configured to fit a tip of the needle electrode. The device further includes an adhesive layer configured to affix the base to the patient.

公开(公告)号：US20230191109A1

公开(公告)日：2023-06-22

申请号：US18059503

申请日：2022-11-29

Applicant: MUSC Foundation for Research Development

Inventor： Bashar Badran ,  Mark George ,  Doe Jenkins ,  Daniel Cook

IPC: A61N1/04 ,  A61N1/36

CPC classification number: A61N1/0452 ,  A61N1/0456 ,  A61N1/36031 ,  A61N1/36034 ,  A61N1/36036

Abstract: The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.

公开(公告)号：US20230110411A1

公开(公告)日：2023-04-13

申请号：US17936986

申请日：2022-09-30

Applicant: Washington University ,  MUSC Foundation for Research Development

Inventor： Eric C. Leuthardt ,  Peter Brunner ,  Kara Donovan ,  Aiko Thompson

IPC: A61N1/36 ,  A61N1/04

Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient’s vagus nerve within a patient’s ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

公开(公告)号：US11602436B2

公开(公告)日：2023-03-14

申请号：US16847320

申请日：2020-04-13

Applicant: MUSC Foundation for Research Development

Inventor： Mark Evald Semler ,  Bruce Frankel ,  Joseph Ruscito

IPC: A61F2/44 ,  A61F2/46 ,  A61F2/30

Abstract: An expandable vertebral body device, system, instrument, and methods of assembly and using the device, system, and instrument are disclosed. The vertebral body device includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, a second rotating member rotatably coupled to the second end, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body device and an insertion instrument. Methods for assembling and using the vertebral body device and instrument are also disclosed.

公开(公告)号：US11260027B2

公开(公告)日：2022-03-01

申请号：US15745913

申请日：2016-06-24

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Satish Nadig ,  Carl Atkinson ,  Ann-Marie Broome ,  Suraj K. Dixit

IPC: A61K9/107 ,  A61K9/127 ,  A61K38/13 ,  A61K9/51 ,  A01N1/02 ,  A61K31/436 ,  A61K31/365 ,  A61K38/20 ,  A61K31/713 ,  A61P37/06 ,  A61K31/343 ,  A61K47/10 ,  A61K31/453 ,  B82Y5/00

Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.