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公开(公告)号：US11719679B2
公开(公告)日：2023-08-08
申请号：US17198879
申请日：2021-03-11
申请人： Li-Cor, Inc.
IPC分类号： G01N33/00
CPC分类号： G01N33/0098
摘要： Gas exchange analysis methods and systems utilize a water vapor buffering component including a material configured to buffer water vapor in a flow of a gas, whereby fluctuations in the water vapor content in the flow of the gas are slowed for components downstream from the water vapor buffering component. Components downstream of the water vapor buffering component may include: a first water vapor sensor configured to receive the flow of the gas from the water vapor buffering component and configured to measure a first concentration of water vapor in the gas; a sample chamber configured to receive the gas exiting the water vapor buffering component or the first water vapor sensor and to hold a sample capable of adding or removing water vapor from the gas; and a second water vapor sensor configured to measure a second concentration of water vapor in the gas exiting the sample chamber.
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公开(公告)号：US20220057360A1
公开(公告)日：2022-02-24
申请号：US17518430
申请日：2021-11-03
申请人： LI-COR, Inc.
发明人： Michael D. Furtaw , Donald T. Lamb
IPC分类号： G01N27/447
摘要： A flat bar piezoelectric actuator affixed to a pressure chamber with one or more separation capillary tubes exiting near respective nozzle orifices is disclosed. The flat actuator against a flat wall of the pump chamber causes a relatively planar pressure wave to pass by the end of each capillary, transporting a precise amount of separated analyte from the capillary out of the nozzle orifice. The nozzle may or may not be tapered. Multiple nozzles can form an inkjet print head that ejects precise droplets of analyte and sheath fluid. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes.
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公开(公告)号：US20220054011A1
公开(公告)日：2022-02-24
申请号：US17405592
申请日：2021-08-18
申请人： LI-COR, Inc.
发明人： Andrew Ragatz , Mark Fiedler
摘要： Multi-modality imaging systems and methods for enabling controllable and/or automated switching between different imaging systems or modes. An imaging system includes a base plate having a first exposed region and a second region, a sample stage configured to hold a sample platform, and a first translation mechanism configured to translate the sample stage on the base plate along a first axis between a first position and a second position. In the first position the sample stage is positioned proximal to the first exposed region, and in the second position, the sample stage is positioned proximal to the second region. An illumination device is configured to illuminate a portion of the first exposed region, and a second translation mechanism is configured to translate the illumination device along a second axis substantially perpendicular to the first axis.
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公开(公告)号：US11241689B2
公开(公告)日：2022-02-08
申请号：US15670896
申请日：2017-08-07
申请人： LI-COR, Inc.
发明人： Michael D. Furtaw , Donald T. Lamb
IPC分类号： G01N27/447 , B01L3/00
摘要： Devices and methods are provided for the separation and dispensing of material using a microfluidic electrophoresis column, sheath liquid pump, and exit channel, all on the same monolithic chip. Material is separated in the electrophoresis column and passed into the exit chamber in response to a voltage potential between a first electrode within the electrophoresis column and a terminating electrode integrated into the chip. The terminating electrode can be in the sheath liquid pump chamber, the sheath liquid reservoir, or a separate flow channel that intersects the exit channel along with the electrophoresis column and sheath liquid pump chamber. The flow of sheath liquid into the exit chamber entrains separated analytes into an effluent that is dispensed out of the exit chamber via a discharge outlet.
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公开(公告)号：US11133087B2
公开(公告)日：2021-09-28
申请号：US16911898
申请日：2020-06-25
申请人： LI-COR, Inc.
发明人： Patrick G. Humphrey
摘要： Systems and methods for automatically identifying and characterizing one or more lanes in image data for one or more electrophoresed samples. The method includes receiving data representing an image of one or more electrophoresed samples, segmenting the data into one or multiple data segments or portions within a region of interest (ROI), wherein the one or multiple data segments represent (e.g., when visually displayed) one or multiple lane segments along a first axis in the ROI, each of the one or multiple lane segments traversing one or multiple lanes in the image data, generating an intensity profile for at least a first data segment of the one or multiple data segments along a second axis orthogonal to the first axis, and processing the intensity profile to determine a location and parameters for each of one or multiple lanes in the first data segment.
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公开(公告)号：US10993622B2
公开(公告)日：2021-05-04
申请号：US15819603
申请日：2017-11-21
申请人： LI-COR, Inc.
发明人： Han-Wei Wang , Lyle R. Middendorf
摘要： Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.
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公开(公告)号：US10988687B2
公开(公告)日：2021-04-27
申请号：US15825339
申请日：2017-11-29
申请人： LI-COR, INC.
发明人： Xinshe Xu , Rose Skopp , Mark Cradduck , Nisha Padhye
摘要： The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
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公开(公告)号：US10758631B2
公开(公告)日：2020-09-01
申请号：US15951911
申请日：2018-04-12
申请人： LI-COR, Inc.
摘要： Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
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公开(公告)号：US20200179514A1
公开(公告)日：2020-06-11
申请号：US16751850
申请日：2020-01-24
申请人： LI-COR, INC.
发明人： JOY L. KOVAR
IPC分类号： A61K41/00 , A61K49/00 , A61N5/06 , A61K47/68 , A61K47/64 , A61K51/08 , A61K51/04 , A61M1/36 , A61K41/10
摘要： The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (
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公开(公告)号：US20190323966A1
公开(公告)日：2019-10-24
申请号：US16456511
申请日：2019-06-28
申请人： LI-COR, Inc.
发明人： Han-Wei Wang , Lyle R. Middendorf
摘要： Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.
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