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    Solid cyanine dyes
    1.
    发明授权
    Solid cyanine dyes 有权

    公开(公告)号：US10758631B2

    公开(公告)日：2020-09-01

    申请号：US15951911

    申请日：2018-04-12

    Applicant: LI-COR, Inc.

    Inventor： Vassil Elitzin ,  William M. Volcheck ,  Katie Schaepe ,  Rahul Patil

    IPC: A61K49/00 ,  C09B23/01 ,  A61M5/00 ,  C09B23/08 ,  A61B5/20 ,  A61B5/00

    Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided.A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.

    IR DYES FOR FLUORESCENCE IMAGING
    3.
    发明申请
    IR DYES FOR FLUORESCENCE IMAGING 审中-公开

    公开(公告)号：US20200085976A1

    公开(公告)日：2020-03-19

    申请号：US16687450

    申请日：2019-11-18

    Applicant: LI-COR, INC.

    Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

    IPC: A61K49/00 ,  A61B5/20 ,  A61B5/00 ,  C09B23/10 ,  C09B23/08 ,  C09B23/01

    Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

    IR dyes for fluorescence imaging
    4.
    发明授权
    IR dyes for fluorescence imaging 有权

    公开(公告)号：US10548991B2

    公开(公告)日：2020-02-04

    申请号：US14949654

    申请日：2015-11-23

    Applicant: LI-COR, Inc.

    Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin

    IPC: A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20

    Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

    HEMICYANINE DYES
    5.
    发明申请
    HEMICYANINE DYES 审中-公开

    公开(公告)号：US20190338131A1

    公开(公告)日：2019-11-07

    申请号：US16404993

    申请日：2019-05-07

    Applicant: LI-COR, Inc.

    Inventor： Silvano Sanchini ,  Rose Skopp ,  Vassil Elitzin ,  Nisha Padhye ,  Teresa Urlacher

    IPC: C09B23/01 ,  G01N33/58

    Abstract: The present disclosure embodies compounds, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

    Hemicyanine dyes
    7.
    发明授权
    Hemicyanine dyes 有权

    公开(公告)号：US11186719B2

    公开(公告)日：2021-11-30

    申请号：US16404993

    申请日：2019-05-07

    Applicant: LI-COR, Inc.

    Inventor： Silvano Sanchini ,  Rose Skopp ,  Vassil Elitzin ,  Nisha Padhye ,  Teresa Urlacher

    IPC: C09B23/01 ,  G01N33/58 ,  C07D209/14 ,  C07D403/12

    Abstract: The present disclosure embodies compounds of Formula I, methods of use thereof, and kits thereof: that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

    IR dyes for fluorescence imaging
    8.
    发明授权
    IR dyes for fluorescence imaging 有权

    公开(公告)号：US11167046B2

    公开(公告)日：2021-11-09

    申请号：US16687450

    申请日：2019-11-18

    Applicant: LI-COR, INC.

    Inventor： Daniel R. Draney ,  William M. Volcheck ,  Katie Schaepe ,  Vassil Elitzin ,  Joy Kovar

    IPC: A61K49/00 ,  C09B23/10 ,  A61B5/00 ,  A61B5/20 ,  C09B23/01 ,  C09B23/08

    Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

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