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公开(公告)号：US20240115819A1
公开(公告)日：2024-04-11
申请号：US18538917
申请日：2023-12-13
CPC分类号： A61M15/08 , A61M11/02 , A61M15/009 , A61M2210/0618
摘要： A delivery device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the compound and the outlet allows for delivery of the compound.
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2.发明公开公开(公告)号：US20230301955A1
公开(公告)日：2023-09-28
申请号：US18313330
申请日：2023-05-06
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61P25/16 , A61K9/00 , A61M15/00 , A61M11/02 , A61M15/08 , A61K9/16 , A61K31/165 , A61K9/48 , A61K9/14
CPC分类号： A61K31/198 , A61P25/16 , A61K9/0075 , A61M15/0036 , A61M11/02 , A61M15/003 , A61M15/08 , A61M15/0035 , A61K9/0043 , A61K9/1623 , A61K9/1652 , A61K31/165 , A61K9/48 , A61K9/14 , A61K9/0053 , A61M15/009 , A61M2202/04 , A61M2202/064 , A61M2206/20 , A61M2205/8225
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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公开(公告)号：US20230095719A1
公开(公告)日：2023-03-30
申请号：US17866222
申请日：2022-07-15
摘要： A deliver device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the compound and the outlet allows for delivery of the compound.
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公开(公告)号：US20220323698A1
公开(公告)日：2022-10-13
申请号：US17835256
申请日：2022-06-08
摘要： A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip that removably couples to the actuator body. The actuator body comprises a propellant channel in fluid communication with a propellant canister. The tip comprises an exit channel, an inlet interface, one or more grooves, and an outlet orifice. The exit channel extends between a proximal end and a distal end of the tip. The inlet interface is positioned about a distal end of the exit channel, and the inlet interface couples to a compound container containing the compound. The grooves are positioned about the inlet interface and direct propellant from the propellant channel into the compound container, thereby agitating and entraining the compound in the compound container with the released propellant. The compound and the propellant then travel through the exit channel and out the outlet orifice.
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公开(公告)号：US11878109B2
公开(公告)日：2024-01-23
申请号：US16875906
申请日：2020-05-15
CPC分类号： A61M11/02 , A61M15/0065 , A61M2210/0618
摘要： Embodiments relate to a single-use device for delivery of medication into a nasal cavity. In an embodiment, the device includes a propellant canister containing a propellant capable of propelling the compound to the nasal cavity. The propellant canister is displaceable between an unactuated position and an actuated position within the device. The device further includes an actuation element with an actuation lever configured to displace the propellant canister from the unactuated position to the actuated position. The device also includes a puncture element positioned to puncture the propellant canister, which causes the release of the propellant from the propellant canister. The device further includes a dose holding chamber containing a unit dose of the compound. The dose holding chamber is positioned such that propellant flows into the dose holding chamber and causes the compound to be propelled from the dose holding chamber to the nasal cavity of the user.
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公开(公告)号：US11752100B2
公开(公告)日：2023-09-12
申请号：US17574511
申请日：2022-01-12
CPC分类号： A61K9/0043 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K31/00 , A61K31/5513 , A61M15/003 , A61P25/18
摘要： Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (Cmax) of at least 30 ng/mL, with (b) a mean time to Cmax (Tmax) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.
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公开(公告)号：US11730903B2
公开(公告)日：2023-08-22
申请号：US16664588
申请日：2019-10-25
CPC分类号： A61M15/08 , A61M11/02 , A61M2202/0468 , A61M2202/064 , A61M2205/073 , A61M2205/8225
摘要： A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
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公开(公告)号：US11517548B2
公开(公告)日：2022-12-06
申请号：US16517423
申请日：2019-07-19
发明人： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC分类号： A61K31/198 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/165 , A61M11/02 , A61M15/00 , A61M15/08 , A61P25/16
摘要： A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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公开(公告)号：US11890412B2
公开(公告)日：2024-02-06
申请号：US17164371
申请日：2021-02-01
发明人： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford
CPC分类号： A61M15/08 , A61M15/0021 , A61M16/127 , B05B1/14 , B05B7/08 , A61M16/208 , A61M2202/064 , A61M2210/0612 , A61M2210/0618 , A61M2210/1067 , A61M2210/1475
摘要： A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
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公开(公告)号：US11878110B2
公开(公告)日：2024-01-23
申请号：US17835256
申请日：2022-06-08
CPC分类号： A61M15/003 , A61M15/0035 , A61M15/08 , A61M15/009 , A61M2202/04 , A61M2202/064 , A61M2205/8225 , A61M2206/20
摘要： A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip that removably couples to the actuator body. The actuator body comprises a propellant channel in fluid communication with a propellant canister. The tip comprises an exit channel, an inlet interface, one or more grooves, and an outlet orifice. The exit channel extends between a proximal end and a distal end of the tip. The inlet interface is positioned about a distal end of the exit channel, and the inlet interface couples to a compound container containing the compound. The grooves are positioned about the inlet interface and direct propellant from the propellant channel into the compound container, thereby agitating and entraining the compound in the compound container with the released propellant. The compound and the propellant then travel through the exit channel and out the outlet orifice.
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