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1.发明申请公开(公告)号：US20130020200A1
公开(公告)日：2013-01-24
申请号：US13560134
申请日：2012-07-27
CPC分类号： G01N15/1218 , B26D7/10 , B26D7/14 , B26F1/00 , B26F1/0084 , B26F1/24 , B26F1/31 , B26F3/02 , G01N15/1031 , G01N15/1245 , G01N2015/0038 , G01N2015/1062 , Y10T137/0391
摘要： A method is provided for detecting, measuring or controlling particles and/or electromagnetic radiation, comprising providing a deformable material containing a deformable aperture defining a path for particles or radiation, adjusting the deformable aperture to a prescribed geometry and/or size by deforming the deformable material to change at least one of the parameters of the path defined by the deformable aperture, and causing the particle or radiation to be detected, measured or controlled to enter the deformable aperture. The method includes the step of monitoring the geometry and/or size of the deformable aperture and controlling the adjustment of the size of the deformable aperture in response to such monitoring. The required apparatus is easily fabricated from inexpensive materials. Furthermore the deformable aperture can be tuned to the appropriate geometry post fabrication, and the ability to adjust the aperture geometry renders it capable of discriminating a plurality of differently sized particles.
摘要翻译： 提供了一种用于检测，测量或控制颗粒和/或电磁辐射的方法，包括提供包含限定用于颗粒或辐射的路径的可变形孔的可变形材料，通过使可变形的 材料以改变由可变形孔径限定的路径的至少一个参数，并且使得可以检测，测量或控制粒子或辐射进入可变形孔径。 该方法包括监测可变形孔径的几何形状和/或尺寸并响应于这种监测来控制可变形孔径尺寸的调节的步骤。 所需的装置容易由廉价的材料制成。 此外，可变形孔可以调整到制造后的适当几何形状，并且调整孔径几何形状的能力使得其能够区分多个不同尺寸的颗粒。
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公开(公告)号：US20130015066A1
公开(公告)日：2013-01-17
申请号：US13575357
申请日：2011-01-26
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N15/12 , G01N27/447
摘要： The flow of particles (18) in an aperture (10) between two reservoirs (14) and (15) is controlled by suspending the particles (18) in a fluid (17) within the aperture (10), applying a potential difference across the aperture (10) so as to tend to electrophoretically transport the particles (18) between a region of higher potential field and a region of lower potential in the fluid (17), applying a pressure differential across the aperture (10) so as to tend to transfer the fluid (17) with the particles (18) therein though the aperture (10) from a high-pressure reservoir (14) to a low-pressure reservoir (15), and adjusting the potential difference and/or the pressure differential across the aperture (10) in order to achieve precise control over the translation of the particles (18) within the aperture (10). This permits precise control of velocity and displacement, and the measured delivery of particles in solution through an aperture from one reservoir to another by means of careful command over electrical potential and pressure differential over the aperture.
摘要翻译： 在两个储存器（14）和（15）之间的孔（10）中的颗粒（18）的流动通过将颗粒（18）悬浮在孔（10）内的流体（17）中来控制， 所述孔径（10）倾向于在所述流体（17）中的较高电场的区域和较低电势区域之间电泳输送所述颗粒（18），在所述孔（10）上施加压力差，以便 倾向于将流体（17）与其中的颗粒（18）通过孔（10）从高压储存器（14）转移到低压储存器（15），并且调节电位差和/或压力 跨越孔径（10）的差分，以便实现对孔（10）内的颗粒（18）的平移的精确控制。 这允许精确控制速度和位移，以及通过对孔上的电势和压力差的仔细指令，通过孔从一个储存器到另一储存器的测量的溶液中的颗粒的输送。
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3.发明授权公开(公告)号：US08247214B2
公开(公告)日：2012-08-21
申请号：US11721047
申请日：2005-07-13
CPC分类号： G01N15/1218 , B26D7/10 , B26D7/14 , B26F1/00 , B26F1/0084 , B26F1/24 , B26F1/31 , B26F3/02 , G01N15/1031 , G01N15/1245 , G01N2015/0038 , G01N2015/1062 , Y10T137/0391
摘要： A method is provided for detecting, measuring or controlling particles and/or electromagnetic radiation, comprising providing a deformable material containing a deformable aperture defining a path for particles or radiation, adjusting the deformable aperture to a prescribed geometry and/or size by deforming the deformable material to change at least one of the parameters of the path defined by the deformable aperture, and causing the particle or radiation to be detected, measured or controlled to enter the deformable aperture. The method includes the step of monitoring the geometry and/or size of the deformable aperture and controlling the adjustment of the size of the deformable aperture in response to such monitoring. The required apparatus is easily fabricated from inexpensive materials. Furthermore the deformable aperture can be tuned to the appropriate geometry post fabrication, and the ability to adjust the aperture geometry renders it capable of discriminating a plurality of differently sized particles.
摘要翻译： 提供了一种用于检测，测量或控制颗粒和/或电磁辐射的方法，包括提供包含限定用于颗粒或辐射的路径的可变形孔的可变形材料，通过使可变形的 材料以改变由可变形孔径限定的路径的至少一个参数，并且使得可以检测，测量或控制粒子或辐射进入可变形孔径。 该方法包括监测可变形孔径的几何形状和/或尺寸并响应于这种监测来控制可变形孔径尺寸的调节的步骤。 所需的装置容易由廉价的材料制成。 此外，可变形孔可以调整到制造后的适当几何形状，并且调整孔径几何形状的能力使得其能够区分多个不同尺寸的颗粒。
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公开(公告)号：US10429347B2
公开(公告)日：2019-10-01
申请号：US14916405
申请日：2014-09-03
申请人： IZON SCIENCE LIMITED
IPC分类号： G01N27/447 , G01N15/12 , G01N27/416 , G01N29/24 , G01N15/10 , G01N15/00 , G01R29/24
摘要： A method of determining a charge of at least one test particle (as herein defined), comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring a value indicative of the other of the electric current or voltage across the aperture; determining a time interval between a first and a second point in time, the second point in time corresponding to a point in time when the measured current or voltage has reached a specific proportion of the measured current or voltage at the first point in time; and determining the charge of the at least one test particle by: determining a value indicative of an electrical velocity component of a total velocity of at least one calibration particle having a known charge, taking into account that the total velocity of the at least one calibration particle comprises a non zero-convective velocity component and the electrical velocity component; determining a value indicative of an electrical velocity component of a total velocity of the at least one test particle, taking into account that the total velocity of the at least one test particle comprises a non-zero convective-velocity component and the electrical velocity component; and using the determined values indicative of the electrical velocity components of the test particle and the calibration particle to calibrate the quantitative relationship between the charge of the at least one test particle and the determined time interval.
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公开(公告)号：US09052262B2
公开(公告)日：2015-06-09
申请号：US13575357
申请日：2011-01-26
IPC分类号： G01N15/12 , G01N27/447
CPC分类号： G01N15/12 , G01N27/447
摘要： The flow of particles (18) in an aperture (10) between two reservoirs (14) and (15) is controlled by suspending the particles (18) in a fluid (17) within the aperture (10), applying a potential difference across the aperture (10) so as to tend to electrophoretically transport the particles (18) between a region of higher potential field and a region of lower potential in the fluid (17), applying a pressure differential across the aperture (10) so as to tend to transfer the fluid (17) with the particles (18) therein though the aperture (10) from a high-pressure reservoir (14) to a low-pressure reservoir (15), and adjusting the potential difference and/or the pressure differential across the aperture (10) in order to achieve precise control over the translation of the particles (18) within the aperture (10). This permits precise control of velocity and displacement, and the measured delivery of particles in solution through an aperture from one reservoir to another by means of careful command over electrical potential and pressure differential over the aperture.
摘要翻译： 在两个储存器（14）和（15）之间的孔（10）中的颗粒（18）的流动通过将颗粒（18）悬浮在孔（10）内的流体（17）中来控制， 所述孔径（10）倾向于在所述流体（17）中的较高电场的区域和较低电势区域之间电泳输送所述颗粒（18），在所述孔（10）上施加压力差，以便 倾向于将流体（17）与其中的颗粒（18）通过孔（10）从高压储存器（14）转移到低压储存器（15），并且调节电位差和/或压力 跨越孔径（10）的差分，以便实现对孔（10）内的颗粒（18）的平移的精确控制。 这允许精确控制速度和位移，以及通过对孔上的电势和压力差的仔细指令，通过孔从一个储存器到另一储存器的测量的溶液中的颗粒的输送。
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公开(公告)号：US20140251825A1
公开(公告)日：2014-09-11
申请号：US14235989
申请日：2012-08-02
IPC分类号： G01N27/416 , G01N27/48
CPC分类号： G01N27/4161 , G01N15/12 , G01N27/48 , G01N33/48721 , G01N33/54313 , G01N2015/0038 , G01N2015/1075
摘要： A method of determining the charge of at least one test particle, comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring the other of the electric current or voltage across the aperture; varying a pressure differential between the two chambers; and determining the charge based on the measurements of the electric current or voltage.
摘要翻译： 一种确定至少一个测试颗粒的电荷的方法，包括：将电流或电压中的一个跨过连接两个室的孔，由此所述室至少部分地填充有电解质，由此所述至少一个测试颗粒是 悬浮在至少一个室的电解质中; 测量孔径上的另一电流或电压; 改变两个室之间的压力差; 以及基于电流或电压的测量来确定电荷。
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公开(公告)号：US09664643B2
公开(公告)日：2017-05-30
申请号：US14235989
申请日：2012-08-02
IPC分类号： G01N27/416 , G01N33/543 , G01N15/12 , G01N27/48 , G01N33/487 , G01N15/10 , G01N15/00
CPC分类号： G01N27/4161 , G01N15/12 , G01N27/48 , G01N33/48721 , G01N33/54313 , G01N2015/0038 , G01N2015/1075
摘要： A method of determining the charge of at least one test particle, comprising: applying one of an electric current or a voltage across an aperture connecting two chambers, whereby the chambers are at least partially filled with electrolyte and whereby the at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring the other of the electric current or voltage across the aperture; varying a pressure differential between the two chambers; and determining the charge based on the measurements of the electric current or voltage.
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