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公开(公告)号：US20120270298A1
公开(公告)日：2012-10-25
申请号：US13523800
申请日：2012-06-14
Applicant: Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
Inventor： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
IPC: C12N9/42
CPC classification number: C12N9/2437 , C11D3/38645 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , D21C5/005 , Y02E50/16
Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
Abstract translation: 本文描述的是H.jecorina CBH I，Cel7酶的变体。 本发明提供了具有改善的热稳定性和可逆性的新型纤维二糖水解酶。
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2.发明授权公开(公告)号：US07858762B2
公开(公告)日：2010-12-28
申请号：US10483842
申请日：2002-07-26
Applicant: Katherine D Collier , Edwin Lee , Nicholas Leiva , Thomas B Morrison , Volker Schellenberger , Olga V Selifonova , Adam C Kean
Inventor： Katherine D Collier , Edwin Lee , Nicholas Leiva , Thomas B Morrison , Volker Schellenberger , Olga V Selifonova , Adam C Kean
Abstract: An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.
Abstract translation: 描述了在蛋白质进化期间表现出连续或高水平表达的枯草芽孢杆菌的可进化生产菌株。 一种进化的枯草芽孢杆菌pstS启动子有助于分泌蛋白的筛选和产生。
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3.发明申请公开(公告)号：US20100221775A1
公开(公告)日：2010-09-02
申请号：US12639921
申请日：2009-12-16
Applicant: Merja E. Penttila , Michael Ward , Huaming Wang , Mari J. Valkonen , Markku L.A. Saloheimo
Inventor： Merja E. Penttila , Michael Ward , Huaming Wang , Mari J. Valkonen , Markku L.A. Saloheimo
CPC classification number: C12N9/16 , C07K14/37 , C12N9/12 , C12Y207/11001 , C12Y301/03016
Abstract: Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In one case, the protein having unfolded protein response modulating activity is selected from the proteins selected from the group consisting of HAC1, PTC2 and IRE1. The protein of interest can be any secreted protein such as a therapeutic or an industrial enzyme. For example the protein can be selected from the group consisting of lipase, cellulase, endo-glucosidase H, protease, carbohydrase, reductase, oxidase, isomerase, transferase, kinase, phosphatase, alpha-amylase, glucoamylase, lignocellulose hemicellulase, pectinase and ligninase.
Abstract translation: 本文描述了增加细胞分泌的蛋白质的量的方法。 在一种情况下，提供了包含编码具有未折叠蛋白质应答调节活性的蛋白质的异源核酸和编码目的蛋白质的异源核酸分泌的细胞。 在一种情况下，具有解折叠的蛋白质反应调节活性的蛋白质选自HAC1，PTC2和IRE1中的蛋白质。 感兴趣的蛋白质可以是任何分泌蛋白质，例如治疗剂或工业酶。 例如，蛋白质可以选自脂肪酶，纤维素酶，内切葡糖苷酶H，蛋白酶，碳水解酶，还原酶，氧化酶，异构酶，转移酶，激酶，磷酸酶，α-淀粉酶，葡糖淀粉酶，木质纤维素半纤维素酶，果胶酶和木质素酶。
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公开(公告)号：US07723079B2
公开(公告)日：2010-05-25
申请号：US12177080
申请日：2008-07-21
Applicant: Nigel Dunn-Coleman , Paulien Neefe-Kruithof , Craig E. Pilgrim , Piet Van Solingen , Donald E. Ward, III
Inventor： Nigel Dunn-Coleman , Paulien Neefe-Kruithof , Craig E. Pilgrim , Piet Van Solingen , Donald E. Ward, III
CPC classification number: C12N9/2428 , C12N1/16 , C12N9/2417 , C12N9/242 , C12N15/8245 , C12P7/06 , C12P19/14 , C12P21/06 , Y02E50/17
Abstract: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences, enzyme compositions and methods of using the glucoamylases in various applications.
Abstract translation: 本发明涉及与具有SEQ ID NO：4的序列及其生物功能性片段的木霉属葡糖淀粉酶具有至少80％序列同一性的葡糖淀粉酶。 本发明还涉及编码葡糖淀粉酶的DNA序列，掺入DNA序列的载体和宿主细胞，酶组合物以及在各种应用中使用葡糖淀粉酶的方法。
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5.发明授权公开(公告)号：US07691806B2
公开(公告)日：2010-04-06
申请号：US11351712
申请日：2006-02-10
Applicant: Katherine D. Collier , William A. Cuevas , Manoj Kumar
Inventor： Katherine D. Collier , William A. Cuevas , Manoj Kumar
CPC classification number: A61K8/64 , A61K38/00 , A61K47/59 , A61K47/64 , A61K2800/57 , A61Q13/00 , A61Q17/04 , C07K14/21 , C07K14/415 , C07K14/43504 , C07K14/43586 , C07K14/4716 , C07K14/4727 , C07K14/4741 , C07K14/78 , C07K2319/00 , C08H1/00 , C08H1/06
Abstract: Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.
Abstract translation: 提供了包含重复序列蛋白质聚合物和至少一种活性剂的缀合产物的生物分子缀合物。 其他方面提供了其制造方法和各种工业和消费者应用。
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Patent Agency Ranking
6.发明申请Trichoderma Reesei Phytase Enzymes, Nucleic Acids Encoding Such Phytase Enzymes, Vectors and Host Cells Incorporating Same and Methods of Making and Using Same 审中-公开里氏木霉植酸酶，编码这样的植酸酶，载体和宿主细胞的核酸以及其制造和使用方法公开(公告)号：US20090246856A1
公开(公告)日：2009-10-01
申请号：US12372680
申请日：2009-02-17
Applicant: Nigel Dunn-Coleman , Frits Goedegebuur , Michael Ward
Inventor： Nigel Dunn-Coleman , Frits Goedegebuur , Michael Ward
CPC classification number: C12N9/16
Abstract: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
Abstract translation: 提供了一种新的DNA，其编码具有从木霉属中分离出的植酸酶活性的酶。 还提供了分离编码具有植酸酶活性的酶的DNA从具有这种DNA的生物中分离的DNA的方法，将DNA转化为合适的宿主生物体，转化的DNA的表达和在饲料中使用表达的植酸酶蛋白作为补充 。
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7.发明授权公开(公告)号：US07592157B2
公开(公告)日：2009-09-22
申请号：US11848213
申请日：2007-08-30
Applicant: Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
Inventor： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
CPC classification number: C12N15/80 , C07K14/811
Abstract: Described herein are protease inhibitors, variants thereof and methods for their production.
Abstract translation: 本文描述的是蛋白酶抑制剂，其变体及其制备方法。
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公开(公告)号：US20090233335A1
公开(公告)日：2009-09-17
申请号：US11825498
申请日：2007-07-06
Applicant: Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Edmund Larenas
Inventor： Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Edmund Larenas
IPC: C12P19/00
CPC classification number: C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01091
Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
Abstract translation: 披露的是灰腐质霉Cel7A（CBH1.1），H.jecorina CBH1变体或嗜热链球菌CBH1的变体，编码它们的核酸及其生产方法。 变体纤维素酶具有7A族糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代。
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公开(公告)号：US20090075336A1
公开(公告)日：2009-03-19
申请号：US12259843
申请日：2008-10-28
Applicant: Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Edmund Larenas
Inventor： Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Edmund Larenas
CPC classification number: C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01091
Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
Abstract translation: 披露的是灰腐质霉Cel7A（CBH1.1），H.jecorina CBH1变体或嗜热链球菌CBH1的变体，编码它们的核酸及其生产方法。 变体纤维素酶具有7A族糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代。
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10.发明授权Proteins producing an altered immunogenic response and methods of making and using the same 有权产生改变的免疫原性反应的蛋白质及其制备和使用方法公开(公告)号：US07476528B2
公开(公告)日：2009-01-13
申请号：US11127947
申请日：2005-05-12
Applicant: David A. Estell , Grant C. Ganshaw , Fiona A. Harding , Edmund A. Larenas , Ayrookaran J. Poulose , Elizabeth E. Sikorski , Elliott P. Russell
Inventor： David A. Estell , Grant C. Ganshaw , Fiona A. Harding , Edmund A. Larenas , Ayrookaran J. Poulose , Elizabeth E. Sikorski , Elliott P. Russell
CPC classification number: C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
Abstract: The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
Abstract translation: 本发明涉及与亲本蛋白质相比显示出降低的变应原性的新型蛋白质变体。 还包括编码新变体的DNA分子，包含DNA的宿主细胞和使蛋白质变得不敏感的方法。
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