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公开(公告)号：US20240360438A1
公开(公告)日：2024-10-31
申请号：US18686764
申请日：2022-08-30
发明人： Hye-Won Song , Samatha Vadrevu , Margaret Nakamoto
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C12N15/1068
摘要： Disclosed herein include systems, methods, compositions, and kits for preserving and/or recovering RNA from fixed and/or permeabilized cells, for example for single cell analysis. In some embodiments, the fixed and/or permeabilized cells are for measuring intracellular target (e.g., protein) expression.
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公开(公告)号：US20240353308A1
公开(公告)日：2024-10-24
申请号：US18734978
申请日：2024-06-05
发明人： Fedor Ilkov
IPC分类号： G01N15/1434 , G01N15/01 , G02B27/10 , G02B27/14
CPC分类号： G01N15/1434 , G02B27/1013 , G02B27/141 , G02B27/145 , G01N15/01
摘要： Systems for detecting light (e.g., in a flow stream) are described. Light detection systems according to certain embodiments include a wavelength separator configured to generate first, second and third predetermined spectral ranges of light from a light source and first, second and third light detection modules configured to receive each of the first, second and third predetermined spectral ranges of light, the light detection modules having a plurality of photodetectors and an optical component that conveys light having a predetermined sub-spectral range to the photodetectors. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) and kits having three or more wavelength separators, a plurality of photodetectors and an optical component are also provided.
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公开(公告)号：USD1048386S1
公开(公告)日：2024-10-22
申请号：US29881378
申请日：2022-12-30
设计人： Vincent Delobelle , Eleanor Bainton , James Leslie Rhodri Jones , Daniel Paul Jenkins , Zoe Georgina Armstrong , Malcolm Stanley Boyd
摘要： FIG. 1 is a front perspective view of an on-body fillable injector, showing our new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a top view thereof;
FIG. 5 is a side view thereof;
FIG. 6 is a side view thereof;
FIG. 7 is a rear view thereof; and,
FIG. 8 is a bottom view thereof.
Portions of the on-body fillable injector shown in dashed lines in FIGS. 1-8 depict unclaimed portions of the on-body fillable injector that are included for environmental purposes only.-
公开(公告)号：US12121407B2
公开(公告)日：2024-10-22
申请号：US17110907
申请日：2020-12-03
发明人： Jeffrey C. O'Bryan , Yiping Ma
CPC分类号： A61B90/39 , A61B5/489 , A61B8/08 , A61B8/488 , B41J3/4073 , B41M5/0047 , B41M5/0076 , C09D11/03 , A61B2090/395
摘要： A device, system, and method for printing a vein map onto a patient's skin may include a probe and a printer. The probe may be configured to identify a location of a target vein beneath the patient's skin. The printer may be configured to receive the location and, using the location, print the vein map onto the patient's skin to indicate the location. The vein map may comprise antimicrobial ink printed onto the patient's skin with one or more colors and/or one or more patterns. The vein map may be a two-dimensional vein map or a three-dimensional vein map that indicates the location of the target vein within the patient, a width of the target vein, and/or a depth of the target vein within the patient.
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公开(公告)号：US20240342394A1
公开(公告)日：2024-10-17
申请号：US18683670
申请日：2021-09-03
发明人： Des Whitney
CPC分类号： A61M5/345 , A61M5/3134 , A61M2039/1077 , A61M2039/1088
摘要： A male needless connector having a tapered elongate tip and a collar compliant with ISO standards, the collar having an outer sidewall surface with a plurality of threads for connection to corresponding inner threads of a pen needle. The male needleless connector having a taper between a distal end of the elongate tip and an inner sidewall of the elongate tip. The male needless connector being configured to receive a pen needle.
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公开(公告)号：US20240342383A1
公开(公告)日：2024-10-17
申请号：US18590423
申请日：2024-02-28
发明人： Hervé Monchoix , Damien Maréchal
CPC分类号： A61M5/31515 , A61M5/16831 , A61M5/3157 , A61M2205/3553
摘要： A plunger device for a drug delivery device is disclosed. The plunger device includes a plunger rod having a proximal end and a distal end configured to be attached to a stopper. The plunger device further includes at least one tracking element operatively connected to an outer surface of the plunger rod, the at least one tracking element extending along a longitudinal axis of the plunger rod. The plunger device also includes at least one power supply operatively connected to the at least one tracking element, and at least one current sensing device operatively connected to the at least one power supply and configured to detect an electrical contact established between the at least one tracking element and a conductive element external to the plunger rod.
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公开(公告)号：US20240342364A1
公开(公告)日：2024-10-17
申请号：US18682965
申请日：2022-08-12
CPC分类号： A61M5/14248 , A61K45/06 , A61M5/16831 , A61M2005/14252 , A61M2005/16863 , A61M2205/0238 , A61M2205/10 , A61M2205/3379 , A61M2205/50 , A61M2205/8206
摘要： A drug delivery device includes a reservoir configured to receive a fluid, a cannula in fluid communication with the reservoir, with the cannula configured to be inserted into subcutaneous tissue or muscle tissue of a patient, and a pump configured to deliver a fluid from the reservoir to the cannula. The cannula includes a bioactive agent configured to cause a tissue response to decrease a pressure required to deliver fluid from the reservoir. The tissue response can include vasodilation, vasoconstriction, increased tissue permeability, increased flow of interstitial fluid or enzymatic deterioration of extracellular matrix.
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公开(公告)号：US12114976B2
公开(公告)日：2024-10-15
申请号：US17183098
申请日：2021-02-23
CPC分类号： A61B5/150992 , A61B5/150343 , A61M25/007 , A61M25/0606 , A61M2025/0008
摘要： A method may include coupling a first delivery device to a catheter assembly, which may include a catheter dwelling within vasculature of a patient. The first delivery device may include a first tubular instrument. In response to the first tubular instrument being in a distal position, a distal surface of the first tubular instrument may be disposed at a first distance beyond the distal tip of the catheter. The method may include coupling a second delivery device to the catheter assembly after uncoupling the first delivery device from the catheter assembly. The second delivery device may include a second tubular instrument. In response to the second tubular instrument being in the distal position, a distal surface of the second tubular instrument may be disposed at a second distance beyond the distal tip of the catheter. The second distance may be greater than the first distance.
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公开(公告)号：US12114971B2
公开(公告)日：2024-10-15
申请号：US17080514
申请日：2020-10-26
CPC分类号： A61B5/1411 , A61B5/150022 , A61B5/150259 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150564 , A61B5/150618 , A61B5/150717 , A61B5/150908 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15142 , A61B5/15144
摘要： The lancet device includes a housing and a lancet having a puncturing element. The lancet is disposed within the housing and is adapted for axial movement between an initial or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward opening in the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet toward the puncturing position, and a retraction or return spring for returning the lancet to a position within the housing where the puncturing element is disposed within the housing. The retraction spring thereafter maintains engagement with the lancet to assist in preventing the puncturing element from again projecting outward from the forward opening in the housing.
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公开(公告)号：US20240335641A1
公开(公告)日：2024-10-10
申请号：US18618940
申请日：2024-03-27
CPC分类号： A61M25/0631 , A61M25/0043 , A61M25/0097 , A61M25/0606
摘要： A catheter system may include a catheter hub, which may include a distal end, a proximal end, and a lumen extending through the distal end of the catheter hub and the proximal end of the catheter hub. The catheter system may include a catheter extending from the distal end of the catheter hub. The catheter system may include a needle hub and an introducer needle extending from the needle hub. The introducer needle may extend through the catheter when the introducer needle is in an advanced position. The catheter system may include a compressible element or another needle shield element configured to shield the introducer needle from distal movement beyond the compressible element or the other needle shield element.
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