公开(公告)号：US07817698B2

公开(公告)日：2010-10-19

申请号：US11836578

申请日：2007-08-09

申请人： Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

发明人： Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

IPC分类号： H01S3/20

CPC分类号： H01S3/022 ,  H01S3/08036 ,  H01S3/1053 ,  H01S3/1055 ,  H01S3/213

摘要： The invention relates to a microfluidic dye laser including a pump light source configured to provide light having a pump light wavelength. The microfluidic dye laser also includes an elastomer substantially optically transparent at the pump light wavelength and at a microfluidic dye laser wavelength. A microfluidic channel configured to accept a fluidic dye is defined in the elastomer. An optical grating is formed in a single mode 3D waveguide in the microfluidic channel in order to provide a single mode microfluidic dye laser light as output in response to illumination with light from the pump light source. In another aspect, the invention features a method of tuning a wavelength of a microfluidic dye laser light by mechanically deforming the elastomeric laser chip to change the grating period in the optical cavity.

摘要翻译： 本发明涉及一种微流体染料激光器，其包括被配置为提供具有泵浦光波长的光的泵浦光源。 微流体染料激光器还包括在泵浦光波长处和微流体染料激光波长基本上光学透明的弹性体。 在弹性体中限定了构造成接受流体染料的微流体通道。 在微流体通道中的单模3D波导中形成光栅，以便响应于来自泵浦光源的光的照明，提供单模微流体染料激光作为输出。 在另一方面，本发明的特征在于通过机械地使弹性体激光芯片变形以改变光腔中的光栅周期来调谐微流体染料激光的波长的方法。

公开(公告)号：US20080159351A1

公开(公告)日：2008-07-03

申请号：US11836578

申请日：2007-08-09

申请人： Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

发明人： Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

IPC分类号： H01S3/20 ,  H01S3/10

CPC分类号： H01S3/022 ,  H01S3/08036 ,  H01S3/1053 ,  H01S3/1055 ,  H01S3/213

摘要： The invention relates to a microfluidic dye laser including a pump light source configured to provide light having a pump light wavelength. The microfluidic dye laser also includes an elastomer substantially optically transparent at the pump light wavelength and at a microfluidic dye laser wavelength. A microfluidic channel configured to accept a fluidic dye is defined in the elastomer. An optical grating is formed in a single mode 3D waveguide in the microfluidic channel in order to provide a single mode microfluidic dye laser light as output in response to illumination with light from the pump light source. In another aspect, the invention features a method of tuning a wavelength of a microfluidic dye laser light by mechanically deforming the elastomeric laser chip to change the grating period in the optical cavity.

摘要翻译： 本发明涉及一种微流体染料激光器，其包括被配置为提供具有泵浦光波长的光的泵浦光源。 微流体染料激光器还包括在泵浦光波长处和微流体染料激光波长基本上光学透明的弹性体。 在弹性体中限定了构造成接受流体染料的微流体通道。 在微流体通道中的单模3D波导中形成光栅，以便响应于来自泵浦光源的光的照明，提供单模微流体染料激光作为输出。 在另一方面，本发明的特征在于通过机械地使弹性体激光芯片变形以改变光腔中的光栅周期来调谐微流体染料激光的波长的方法。

公开(公告)号：US09365816B2

公开(公告)日：2016-06-14

申请号：US13230933

申请日：2011-09-13

申请人： Zhenyu Li ,  Axel Scherer

发明人： Zhenyu Li ,  Axel Scherer

IPC分类号： B01L3/00 ,  C12M1/00 ,  C12N1/06

CPC分类号： C12M47/06 ,  C12N1/066

摘要： Apparatus and methods for mechanical cell lysis with single cell resolution which requires very low applied pressure. The device can be handheld, simple to operate, requires no external power except for hand-applied pressure via a syringe, and is applicable to all cell types including yeast and bacterial cells. The device is also capable of mechanically lysing a single cell. A single cell is selected from a biological sample of interest. The single cell is lysed by application of mechanical stress in a single cell lysing apparatus having a trap structure for deterministically capturing the cell and a stress raiser that cooperates with a source of mechanical stress so as to apply sufficient force to rupture a cell. The stress raiser can be a properly designed edge of the trap or it can be a lithographically produced structure such as a nanoblade or a nanopillar.

摘要翻译： 用于单细胞分辨率的机械细胞裂解的装置和方法，其需要非常低的施加压力。 该装置可以是手持式的，操作简单，除了通过注射器的手动施加的压力外，不需要外部功率，并且适用于包括酵母和细菌细胞在内的所有细胞类型。 该装置还能够机械裂解单个电池。 从感兴趣的生物样品中选择单个细胞。 单细胞通过在具有用于确定性捕获细胞的捕获结构的单细胞裂解装置中施加机械应力而裂解，并且应力提升器与机械应力源协作以施加足够的力使细胞破裂。 应力提升器可以是陷阱的适当设计的边缘，或者它可以是光刻产生的结构，例如纳米颗粒或纳米柱。

公开(公告)号：US20120091235A1

公开(公告)日：2012-04-19

申请号：US13230933

申请日：2011-09-13

申请人： Zhenyu Li ,  Axel Scherer

发明人： Zhenyu Li ,  Axel Scherer

IPC分类号： C12N1/06

CPC分类号： C12M47/06 ,  C12N1/066

摘要： Apparatus and methods for mechanical cell lysis with single cell resolution which requires very low applied pressure. The device can be handheld, simple to operate, requires no external power except for hand-applied pressure via a syringe, and is applicable to all cell types including yeast and bacterial cells. The device is also capable of mechanically lysing a single cell. A single cell is selected from a biological sample of interest. The single cell is lysed by application of mechanical stress in a single cell lysing apparatus having a trap structure for deterministically capturing the cell and a stress raiser that cooperates with a source of mechanical stress so as to apply sufficient force to rupture a cell. The stress raiser can be a properly designed edge of the trap or it can be a lithographically produced structure such as a nanoblade or a nanopillar.

摘要翻译： 用于单细胞分辨率的机械细胞裂解的装置和方法，其需要非常低的施加压力。 该装置可以是手持式的，操作简单，除了通过注射器的手动施加的压力外，不需要外部功率，并且适用于包括酵母和细菌细胞在内的所有细胞类型。 该装置还能够机械裂解单个电池。 从感兴趣的生物样品中选择单个细胞。 单细胞通过在具有用于确定性捕获细胞的捕获结构的单细胞裂解装置中施加机械应力而裂解，并且应力提升器与机械应力源协作以施加足够的力使细胞破裂。 应力提升器可以是陷阱的适当设计的边缘，或者它可以是光刻产生的结构，例如纳米颗粒或纳米柱。

公开(公告)号：US08825864B2

公开(公告)日：2014-09-02

申请号：US13423024

申请日：2012-03-16

申请人： Zhenyu Li ,  Lidan Liu

发明人： Zhenyu Li ,  Lidan Liu

IPC分类号： G06F15/173 ,  G06F15/16

CPC分类号： H04L47/70 ,  G06F8/60 ,  G06F9/5072 ,  G06F2209/508

摘要： A system and method can support dynamically scaling up/down transactional resources in a transactional middleware machine environment. Transactional resources, such as groups and machines, can be by added or removed using a dynamic resource broker according to resource usage changes. The transactional middleware machine environment can comprise a deployment center in the transactional middleware machine environment, wherein the deployment center maintains one or more deployment policies for the transactional middleware machine environment and one or more deployment agents. Each of the one or more deployment agents is associated with a transactional middleware machine of a plurality of transactional middleware machines in a transactional domain in the transactional middleware machine environment. The deployment center operates to receive machine usage information from the one or more deployment agents, and dynamically scale up/down resources used in the transactional domain based on the resource usage information collected by the one or more deployment agents.

摘要翻译： 系统和方法可以支持在事务性中间件机器环境中动态扩展上/下交易资源。 根据资源使用情况的变化，可以使用动态资源代理来添加或删除事务资源（如组和机器）。 交易中间件机器环境可以包括事务中间件机器环境中的部署中心，其中部署中心维护事务中间件机器环境和一个或多个部署代理的一个或多个部署策略。 所述一个或多个部署代理中的每一个与交易中间件机器环境中的事务域中的多个事务中间件机器的事务性中间件机器相关联。 所述部署中心用于从一个或多个部署代理接收机器使用信息，并且基于由所述一个或多个部署代理收集的资源使用信息来动态地扩展/减少事务域中使用的资源。

公开(公告)号：US08690075B2

公开(公告)日：2014-04-08

申请号：US13290509

申请日：2011-11-07

申请人： Sana Mahmood ,  Zhenyu Li ,  Michael Curtis Herr ,  Gregory William Hefler ,  Linda Angharad Williams

发明人： Sana Mahmood ,  Zhenyu Li ,  Michael Curtis Herr ,  Gregory William Hefler ,  Linda Angharad Williams

IPC分类号： F02M47/02 ,  F02M51/06 ,  F02D7/00

CPC分类号： F02M47/027 ,  F02M55/008 ,  F02M2200/28

摘要： A common rail fuel injector includes a needle valve member that moves to open and close nozzle outlets for a fuel injection event responsive to pressure in a needle control chamber. Between injection events, the needle control chamber is fluidly connected to the fuel inlet by a first pathway that includes a Z orifice, and fluidly connected to the fuel inlet by a second pathway that includes an F orifice, an intermediate chamber and an A orifice. During an injection event, the needle control chamber is fluidly connected to a drain outlet by a third pathway that includes the A orifice, the intermediate chamber an E orifice and a buffer chamber, which may assist in avoiding cavitation erosion in a sensitive area associated with a flat control valve seat. Different performance characteristics are achieved by adjusting the sizes of the respective of F, A, Z and E orifices.

摘要翻译： 共轨燃料喷射器包括针阀构件，该针阀构件响应于针控制室中的压力移动以打开和关闭用于燃料喷射事件的喷嘴出口。 在注射事件之间，针控制室通过包括Z孔的第一路径流体地连接到燃料入口，并且通过包括F孔，中间室和A孔的第二路径流体地连接到燃料入口。 在注射事件期间，针控制室通过包括A孔，中间室，E孔和缓冲室的第三路径流体地连接到排水口，该孔可有助于避免在与 平面控制阀座。 通过调整F，A，Z和E各孔的大小来实现不同的性能特征。

公开(公告)号：US08622046B2

公开(公告)日：2014-01-07

申请号：US12823623

申请日：2010-06-25

申请人： Michael D. Gerstner ,  Kenneth C. Adams ,  Benjamin R. Tower ,  Bharath Chandrashekar ,  Zhenyu Li

发明人： Michael D. Gerstner ,  Kenneth C. Adams ,  Benjamin R. Tower ,  Bharath Chandrashekar ,  Zhenyu Li

IPC分类号： F02M63/04

CPC分类号： F02M55/02 ,  F02M55/004 ,  F02M55/025 ,  F02M61/165 ,  F02M63/0054 ,  F02M63/0285

摘要： A fuel system for an engine is disclosed. The fuel system may have a pump, a plurality of fuel injectors, and a plurality of fuel accumulators. Each of the plurality of fuel accumulators may be disposed at least partially within a different cylinder head of the engine in fluid communication with an associated fuel injector of the plurality of fuel injectors. Each of the plurality of fuel accumulators may also be in fluid communication with adjacent fuel accumulators of the plurality of fuel accumulators. At least one of the plurality of fuel accumulators may also be in fluid communication with the pump. The fuel system may further have a plurality of flow limiters. Each of the plurality of flow limiters may be disposed between an associated fuel accumulator of the plurality of fuel accumulators and an associated fuel injector of the plurality of fuel injectors.

摘要翻译： 公开了一种用于发动机的燃料系统。 燃料系统可以具有泵，多个燃料喷射器和多个燃料蓄积器。 多个燃料蓄积器中的每一个可以至少部分地布置在与多个燃料喷射器的相关联的燃料喷射器流体连通的发动机的不同气缸盖内。 多个燃料蓄积器中的每一个也可以与多个燃料蓄积器的相邻燃料蓄积器流体连通。 多个燃料蓄积器中的至少一个也可以与泵流体连通。 燃料系统还可以具有多个流量限制器。 多个流量限制器中的每一个可以设置在多个燃料蓄积器的相关联的燃料蓄积器和多个燃料喷射器的相关联的燃料喷射器之间。

公开(公告)号：US08561593B2

公开(公告)日：2013-10-22

申请号：US12718171

申请日：2010-03-05

申请人： Scott F. Shafer ,  Zhenyu Li

发明人： Scott F. Shafer ,  Zhenyu Li

IPC分类号： F02M69/46 ,  F02M55/02

CPC分类号： F02M63/0285

摘要： A pump and rail assembly includes a plurality of quills that are compressed between quill seats on a pump and an output rail. A rail pressure control valve and a rail pressure sensor are attached to respective ends of the output rail. An inlet throttle valve is attached to a housing of the pump and rail assembly. Depending upon the application, the output rail may supply fuel to a first injection bank that includes a plurality of fuel injectors in a first common rail, and a second fuel injection bank that includes a second common rail and a plurality of fuel injectors. Different engines having different numbers of cylinders may use similar pump and rail assemblies that each include a plurality of quills, a plurality of pumping elements positioned in a pump housing and an output rail. The quills for each of the different engine applications are interchangeable but differ in number. In addition, the pumping elements of each of the different engine applications are also interchangeable but differ in number.

摘要翻译： 泵和轨道组件包括在泵上的轴承座和输出轨道之间被压缩的多个套筒。 轨道压力控制阀和轨道压力传感器连接到输出轨道的相应末端。 入口节流阀连接到泵和导轨组件的壳体。 根据应用，输出轨道可以向包括第一共轨中的多个燃料喷射器的第一注入组提供燃料，以及包括第二共轨和多个燃料喷射器的第二燃料喷射组。 具有不同数量的气缸的不同发动机可以使用类似的泵和轨道组件，其各自包括多个套筒，定位在泵壳体中的多个泵送元件和输出轨道。 每个不同发动机应用的套筒可互换，但数量不同。 此外，不同发动机应用中的每一个的泵送元件也是可互换的，但数量不同。

公开(公告)号：US09003397B2

公开(公告)日：2015-04-07

申请号：US13423035

申请日：2012-03-16

申请人： Zhenyu Li ,  Lidan Liu

发明人： Zhenyu Li ,  Lidan Liu

IPC分类号： G06F9/445 ,  H04L12/911 ,  G06F9/50

CPC分类号： H04L47/70 ,  G06F8/60 ,  G06F9/5072 ,  G06F2209/508

摘要： A system and method can support automatically deploying application components in a transactional middleware machine environment. A deployment center can receive one or more application packages, each of which contains binary files for one or more transactional servers and configuration information that describes relationship and parameters of the one or more transactional servers in the application package. The deployment center can further generate one or more distribution packages for each transactional middleware machine in the transactional middleware machine environment based on the one or more application packages. Then, the deployment center can deploy the one or more distribution packages to the plurality of transactional middleware machines in the transactional middleware machine environment.

摘要翻译： 系统和方法可以支持在事务中间件机器环境中自动部署应用程序组件。 部署中心可以接收一个或多个应用程序包，每个应用程序包都包含一个或多个事务性服务器的二进制文件以及描述应用程序包中一个或多个事务性服务器的关系和参数的配置信息。 基于一个或多个应用程序包，部署中心可以进一步为交易中间件机器环境中的每个事务性中间件机器生成一个或多个分发程序包。 然后，部署中心可以将一个或多个分发包部署到事务中间件机器环境中的多个事务中间件机器。

公开(公告)号：US08898271B2

公开(公告)日：2014-11-25

申请号：US13410128

申请日：2012-03-01

申请人： Zhenyu Li ,  Xuhui Chen

发明人： Zhenyu Li ,  Xuhui Chen

IPC分类号： G06F15/173 ,  G06F15/16 ,  H04L29/08 ,  G06F9/50

CPC分类号： G06F9/505 ,  H04L67/1002 ,  H04L67/1095 ,  H04L67/288

摘要： A system and method can support accurate load balancing in a transactional middleware machine environment with a plurality of transactional middleware machines. A service response time table can be maintained on each transactional middleware machine in the transactional middleware machine environment, wherein said service response time table is adaptive to be used by a client on the transactional middleware machine to make routing decisions for a service request. The transactional middleware machine environment can further include a plurality of synchronization servers, with each said synchronization server associated with a transactional middleware machine in the transactional middleware machine environment. The plurality of synchronization servers operates to periodically synchronize the service response time table on each said transactional middleware machine in the transactional middleware machine environment.

摘要翻译： 系统和方法可以支持在具有多个事务性中间件机器的事务中间件机器环境中的精确负载平衡。 可以在事务中间件机器环境中的每个事务性中间件机器上维护服务响应时间表，其中所述服务响应时间表被自适应地由交易中间件机器上的客户端使用以为服务请求做出路由决定。 交易中间件机器环境可以进一步包括多个同步服务器，每个所述同步服务器与交易中间件机器环境中的事务中间件机器相关联。 多个同步服务器操作以周期性地同步事务中间件机器环境中的每个所述事务中间件机器上的服务响应时间表。