公开(公告)号：US10882817B2

公开(公告)日：2021-01-05

申请号：US16676575

申请日：2019-11-07

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： C07C219/14 ,  A61K31/621 ,  C07C213/06

摘要： A disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.

公开(公告)号：US12065397B2

公开(公告)日：2024-08-20

申请号：US18154520

申请日：2023-01-13

申请人： ZHEJIANG YUEJIA PHARMACEUTICALS CO., LTD

发明人： Jing Zhang

IPC分类号： C07C229/38 ,  A61P29/00 ,  C07C291/04 ,  C07D319/08

CPC分类号： C07C229/38 ,  A61P29/00 ,  C07C291/04 ,  C07D319/08

摘要： Disclosed are benzoate derivatives. Provided is a compound having a formula selected from the group consisting of following structures. The compound can be used for quality control over a 2-(diethylamino)ethyl 2-acetoxybenzoate hydrochloride product, and also for inflammation diminishment

公开(公告)号：US10532973B2

公开(公告)日：2020-01-14

申请号：US15562222

申请日：2016-03-07

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： C07C219/14 ,  C07C213/06

摘要： Disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.

公开(公告)号：US11986453B2

公开(公告)日：2024-05-21

申请号：US18312466

申请日：2023-05-04

申请人： ZHEJIANG YUEJIA PHARMACEUTICALS CO., LTD

发明人： Jing Zhang

IPC分类号： A61K31/245 ,  A61K9/08 ,  A61K31/216

CPC分类号： A61K31/245 ,  A61K9/08 ,  A61K31/216

摘要： A stable pharmaceutical composition containing a non-steroidal anti-inflammatory drug derivative, at least comprising a separated solid part and liquid part, the solid part comprising a therapeutically effective dose of non-steroidal anti-inflammatory drug derivative and the liquid part being a pharmaceutically acceptable solvent.

公开(公告)号：US11278513B2

公开(公告)日：2022-03-22

申请号：US16764434

申请日：2018-09-29

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： A61K31/24 ,  A61P23/02 ,  A61K31/618

摘要： Provided is an application of a compound represented by general formula 1 in the preparation of a local anesthetic. The local anesthetic comprises at least a solid portion and a liquid portion that are separated. The solid portion comprises a therapeutically effective amount of the compound represented by general formula 1. The liquid portion is a pharmaceutically acceptable solvent. The solid portion and the liquid portion are mixed when the local anesthetic is used.

公开(公告)号：US20180305296A1

公开(公告)日：2018-10-25

申请号：US15562222

申请日：2016-03-07

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： C07C219/14 ,  C07C213/06

CPC分类号： C07C219/14 ,  A61K31/621 ,  C07B2200/13 ,  C07C213/06

摘要： Disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.

公开(公告)号：US10987689B1

公开(公告)日：2021-04-27

申请号：US16902354

申请日：2020-06-16

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： B05B11/00 ,  B65D51/28 ,  B65D41/02 ,  B05B15/30

摘要： A bottle and a bottle cap device thereof are provided. In the bottle cap device, the outer-cap outer ring is threadedly connected with the inner-cap outer ring, the outer-cap inner ring penetrates through the inner-cap inner ring, the lower end of the outer-cap inner ring protrudes for a distance from the inner-cap inner ring, and the guide tube is arranged to extend in the outer-cap inner ring. The distance is sufficient to allow the end cap to be connected with the lower end of the outer-cap inner ring in a releasably sealing manner, and when the outer-cap outer ring is turned toward the loosening direction, the distance is sufficiently shortened to allow the end cap abutting with the inner-cap inner ring; while the end cap is connected with the inner-cap inner ring, the guide tube is connected with the end-cap hole, such that a stockage space is formed.