公开(公告)号：US08361536B2

公开(公告)日：2013-01-29

申请号：US12593110

申请日：2007-10-10

申请人： Zhanjiang Yu

发明人： Zhanjiang Yu

IPC分类号： A61L33/00 ,  A61M25/00 ,  B05D3/00

CPC分类号： A61L31/047 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/256

摘要： A method for fixing antibody on the surface of medical instrument, mainly includes: 1) pre-treating the instrument surface; 2) preparing holes: preparing multicrystal phase structure which has same size holes in the surface of the instrument by chemical corrosion, electrochemical corrosion, anodic oxidation, micro-arc oxidation, micro-arc nitridation; 3) post-treating the instrument surface; 4) fixing the antibody: immerging the bare metal scaffold which has holes in surface into a buffer solution containing antibody, adjusting the pH value of the antibody buffer solution, fixing the antibody on the surface of the instrument by the attraction between positive and negative charge and hole effect; and 5) confirming the effectiveness of the fixed antibody by artificial simulation hemodynamics and detecting method of antibody activity in scaffold surface.

摘要翻译： 在医疗器械表面固定抗体的方法主要包括：1）预处理仪器表面; 2）制备孔：通过化学腐蚀，电化学腐蚀，阳极氧化，微弧氧化，微弧氮化，制备在仪器表面具有相同尺寸孔的多晶相结构; 3）后处理仪器表面; 4）固定抗体：将具有表面孔的裸金属支架浸入含有抗体的缓冲溶液中，调节抗体缓冲溶液的pH值，通过正电荷和负电荷之间的吸引将抗体固定在仪器表面上 孔效应; 和5）通过人工模拟血液动力学确定固定抗体的有效性，并在支架表面检测抗体活性的方法。

公开(公告)号：US20100112189A1

公开(公告)日：2010-05-06

申请号：US12593110

申请日：2007-10-10

申请人： Zhanjiang Yu

发明人： Zhanjiang Yu

IPC分类号： B05D3/00

CPC分类号： A61L31/047 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/256

摘要： A method for fixing antibody on the surface of medical instrument, mainly includes: 1) pre-treating the instrument surface; 2) preparing holes: preparing multicrystal phase structure which has same size holes in the surface of the instrument by chemical corrosion, electrochemical corrosion, anodic oxidation, micro-arc oxidation, micro-arc nitridation; 3) post-treating the instrument surface; 4) fixing the antibody: immerging the bare metal scaffold which has holes in surface into a buffer solution containing antibody, adjusting the pH value of the antibody buffer solution, fixing the antibody on the surface of the instrument by the attraction between positive and negative charge and hole effect; and 5) confirming the effectiveness of the fixed antibody by artificial simulation hemodynamics and detecting method of antibody activity in scaffold surface. The method can promote the firm degree of the antibody which is fixed on the surface of the instrument, and keep high activity of the antibody on the surface of medical instrument.

摘要翻译： 在医疗器械表面固定抗体的方法主要包括：1）预处理仪器表面; 2）制备孔：通过化学腐蚀，电化学腐蚀，阳极氧化，微弧氧化，微弧氮化，制备在仪器表面具有相同尺寸孔的多晶相结构; 3）后处理仪器表面; 4）固定抗体：将具有表面孔的裸金属支架浸入含有抗体的缓冲溶液中，调节抗体缓冲溶液的pH值，通过正电荷和负电荷之间的吸引将抗体固定在仪器表面上 孔效应; 和5）通过人工模拟血液动力学确定固定抗体的有效性，并在支架表面检测抗体活性的方法。 该方法可以促进固定在仪器表面的抗体的牢固程度，并保持抗体在医疗器械表面的高活性。

公开(公告)号：US20100049308A1

公开(公告)日：2010-02-25

申请号：US12515044

申请日：2007-10-16

申请人： Zhanjiang Yu

发明人： Zhanjiang Yu

IPC分类号： A61F2/06

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/61

摘要： A stent with multi drug-coatings includes a stent body and active drugs. A portion of the surface or the entire surface of the stent body is covered with at least one layer of active drug coating. Use of such a stent not only can accelerate endothelialization of coronary, but also resist cell proliferation, resist the migration of smooth muscle cells, reduce the formation of thrombus and the inflammatory reaction of cells and recover the flexibility of vascular tissues. Multi drug-coatings can prevent the multiple phases of restenosis, resist the release of drugs at different phases of endothelial repair, and play a role in co-resisting vessel stent restenosis by various drugs. Well-composed multi drug-coatings make the coating area and coating layers of drug-eluting stent and drugs compatibility more reasonable, make the use of drug-eluting stent more secure, and produce better treatment effects.

摘要翻译： 具有多种药物涂层的支架包括支架体和活性药物。 支架主体的表面或整个表面的一部分被至少一层活性药物涂层覆盖。 使用这种支架不仅可以加速冠状动脉的内皮化，而且可以抵抗细胞增殖，抵抗平滑肌细胞的迁移，减少血栓的形成和细胞的炎症反应，并恢复血管组织的柔韧性。 多药物涂层可以预防再狭窄的多个阶段，抵抗内皮修复不同阶段的药物释放，并通过各种药物共同抵抗血管支架再狭窄发挥作用。 组合多药物涂层使药物洗脱支架和药物相容性的涂层面积和涂层更加合理，使药物洗脱支架的使用更加安全，产生更好的治疗效果。