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    System for providing diabetic therapy
    1.
    发明授权
    System for providing diabetic therapy 有权
    糖尿病治疗系统

    公开(公告)号：US08634930B2

    公开(公告)日：2014-01-21

    申请号：US11428070

    申请日：2006-06-30

    Applicant: Yousufali Dalal ,  Andrew P. Kramer ,  Lizbeth M. Mino

    Inventor： Yousufali Dalal ,  Andrew P. Kramer ,  Lizbeth M. Mino

    IPC: A61N1/36

    CPC classification number: A61N1/37288 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/36557 ,  A61N1/36585 ,  A61N1/37282

    Abstract: Various system embodiments include a glucose control input, a low physical activity input, and a diabetic therapy delivery system adapted to respond to the glucose control input and the low physical activity input to deliver diabetic therapy. According to various embodiments, the diabetic therapy includes an anti-arrhythmia therapy, a hypertension therapy, a neural stimulation therapy adapted to reduce a risk of myocardial infarction, a neural stimulation therapy adapted to be applied after a myocardial infarction to reduce an infarct area, a neural stimulation therapy adapted to reduce a risk of sudden cardiac death, a therapy adapted to secrete insulin, or a therapy to reduce a workload of a diabetic heart. Other aspects and embodiments are provided herein.

    Abstract translation: 各种系统实施方案包括葡萄糖控制输入，低体力活动输入和适于响应于葡萄糖控制输入和低体力活动输入以递送糖尿病治疗的糖尿病治疗递送系统。 根据各种实施方案，糖尿病治疗包括抗心律失常治疗，高血压治疗，适于降低心肌梗死风险的神经刺激疗法，适于在心肌梗死后应用以减少梗死面积的神经刺激疗法， 适于减少心源性猝死的风险的神经刺激疗法，适于分泌胰岛素的治疗剂或减少糖尿病心脏的工作量的治疗方法。 本文提供了其它方面和实施例。

    SYSTEM FOR PROVIDING DIABETIC THERAPY
    2.
    发明申请
    SYSTEM FOR PROVIDING DIABETIC THERAPY 有权
    提供糖尿病治疗的系统

    公开(公告)号：US20080004672A1

    公开(公告)日：2008-01-03

    申请号：US11428070

    申请日：2006-06-30

    Applicant: Yousufali Dalal ,  Andrew P. Kramer ,  Lizbeth M. Mino

    Inventor： Yousufali Dalal ,  Andrew P. Kramer ,  Lizbeth M. Mino

    IPC: A61N1/18

    CPC classification number: A61N1/37288 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/36557 ,  A61N1/36585 ,  A61N1/37282

    Abstract: Various system embodiments include a glucose control input, a low physical activity input, and a diabetic therapy delivery system adapted to respond to the glucose control input and the low physical activity input to deliver diabetic therapy. According to various embodiments, the diabetic therapy includes an anti-arrhythmia therapy, a hypertension therapy, a neural stimulation therapy adapted to reduce a risk of myocardial infarction, a neural stimulation therapy adapted to be applied after a myocardial infarction to reduce an infarct area, a neural stimulation therapy adapted to reduce a risk of sudden cardiac death, a therapy adapted to secrete insulin, or a therapy to reduce a workload of a diabetic heart. Other aspects and embodiments are provided herein.

    Abstract translation: 各种系统实施方案包括葡萄糖控制输入，低体力活动输入和适于响应于葡萄糖控制输入和低体力活动输入以递送糖尿病治疗的糖尿病治疗递送系统。 根据各种实施方案，糖尿病治疗包括抗心律失常治疗，高血压治疗，适于降低心肌梗死风险的神经刺激疗法，适于在心肌梗死后应用以减少梗死面积的神经刺激疗法， 适于减少心源性猝死的风险的神经刺激疗法，适于分泌胰岛素的治疗剂或减少糖尿病心脏的工作量的治疗方法。 本文提供了其它方面和实施例。

    Cardiac rhythm management device with neural sensor
    3.
    发明授权
    Cardiac rhythm management device with neural sensor 有权

    公开(公告)号：US09409025B2

    公开(公告)日：2016-08-09

    申请号：US12840449

    申请日：2010-07-21

    Applicant: Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    Inventor： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    IPC: A61N1/36 ,  A61N1/362

    CPC classification number: A61N1/3627 ,  A61N1/36114 ,  A61N1/36117

    Abstract: Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

    SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION
    5.
    发明申请
    SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
    闭环神经刺激的系统和方法

    公开(公告)号：US20130165998A1

    公开(公告)日：2013-06-27

    申请号：US13709271

    申请日：2012-12-10

    Applicant: Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    Inventor： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    IPC: A61N1/36

    CPC classification number: A61N1/36053 ,  A61N1/36117

    Abstract: Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.

    Abstract translation: 各种装置实施例包括脉冲发生器，信号处理模块和控制器。 脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。 信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。 控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。 控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。 本文提供了其它方面和实施例。

    System and method for neural stimulation
    6.
    发明授权
    System and method for neural stimulation 有权

    公开(公告)号：US08457734B2

    公开(公告)日：2013-06-04

    申请号：US11468135

    申请日：2006-08-29

    Applicant: Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhao

    Inventor： Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhao

    IPC: A61N1/365

    CPC classification number: A61N1/365 ,  A61N1/36053 ,  A61N1/36114

    Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

    System and method for closed-loop neural stimulation
    8.
    发明授权
    System and method for closed-loop neural stimulation 有权
    闭环神经刺激的系统和方法

    公开(公告)号：US08396560B2

    公开(公告)日：2013-03-12

    申请号：US10992319

    申请日：2004-11-18

    Applicant: Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    Inventor： Imad Libbus ,  Andrew P. Kramer ,  Julia Moffitt

    IPC: A61N1/18

    CPC classification number: A61N1/36117 ,  A61N1/08 ,  A61N1/36171

    Abstract: Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

    Abstract translation: 本主题的各个方面提供了一种装置。 在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并且适于接收和处理 神经交通信号从引导到指示神经交通的信号。 该装置包括连接到脉冲发生器和信号处理模块的控制器。 控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。 本文提供了其他方面。

    CARDIAC RHYTHM MANAGEMENT SYSTEM SELECTING BETWEEN MULTIPLE SAME-CHAMBER ELECTRODES FOR DELIVERING CARDIAC THERAPY
    10.
    发明申请
    CARDIAC RHYTHM MANAGEMENT SYSTEM SELECTING BETWEEN MULTIPLE SAME-CHAMBER ELECTRODES FOR DELIVERING CARDIAC THERAPY 有权
    CARDIAC RHYTHM管理系统选择用于提供心脏治疗的多个相同电极

    公开(公告)号：US20130030485A1

    公开(公告)日：2013-01-31

    申请号：US13646720

    申请日：2012-10-07

    Applicant: Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    Inventor： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    IPC: A61N1/365

    CPC classification number: A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

    Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

    Abstract translation: 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

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