公开(公告)号：US08859807B2

公开(公告)日：2014-10-14

申请号：US12444298

申请日：2007-10-04

申请人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

发明人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

IPC分类号： C07C323/39 ,  A61K47/18 ,  A61K38/06

CPC分类号： A61K47/183 ,  A61K38/063

摘要： The present invention relates to a method of improving the preservation stability of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. In addition, the present invention relates to a production method of a glutathione preparation, which is characterized by mixing glutathione and an arginine-acidic amino acid salt. By the production method, a glutathione preparation that resists quality deterioration can be provided. Moreover, the present invention relates to a preservation method of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. By the preservation method, quality deterioration of glutathione during preservation can be suppressed.

摘要翻译： 本发明涉及一种提高谷胱甘肽保存稳定性的方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 此外，本发明涉及谷胱甘肽制剂的制备方法，其特征在于将谷胱甘肽和精氨酸 - 酸性氨基酸盐混合。 通过该制造方法，可以提供抗恶化的谷胱甘肽制剂。 此外，本发明涉及谷胱甘肽的保存方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 通过保存方法，可以抑制保存期间谷胱甘肽的质量恶化。

公开(公告)号：US20100048948A1

公开(公告)日：2010-02-25

申请号：US12444298

申请日：2007-10-04

申请人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

发明人： Yasushi Sakai ,  Aki Kato ,  Masao Kimura

IPC分类号： C07C323/39

CPC分类号： A61K47/183 ,  A61K38/063

摘要： The present invention relates to a method of improving the preservation stability of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. In addition, the present invention relates to a production method of a glutathione preparation, which is characterized by mixing glutathione and an arginine-acidic amino acid salt. By the production method, a glutathione preparation that resists quality deterioration can be provided. Moreover, the present invention relates to a preservation method of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. By the preservation method, quality deterioration of glutathione during preservation can be suppressed.

摘要翻译： 本发明涉及一种提高谷胱甘肽保存稳定性的方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 此外，本发明涉及谷胱甘肽制剂的制备方法，其特征在于将谷胱甘肽和精氨酸 - 酸性氨基酸盐混合。 通过该制造方法，可以提供抗恶化的谷胱甘肽制剂。 此外，本发明涉及谷胱甘肽的保存方法，其特征在于允许谷胱甘肽与精氨酸 - 酸性氨基酸盐共存。 通过保存方法，可以抑制保存期间谷胱甘肽的质量恶化。

公开(公告)号：US20090053798A1

公开(公告)日：2009-02-26

申请号：US11909391

申请日：2006-03-30

申请人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

发明人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： C12N1/04 ,  A23L1/48

CPC分类号： C12N1/04

摘要： The present invention relates to a method of improving storage stability of dried microorganisms, such as dried lactic acid bacteria, by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt, a composition comprising dried microorganisms and an L-arginine acidic amino acid salt and a process for producing the same, and a method of storing dried microorganisms in the presence of an L-arginine acidic amino acid salt. The storage stability of dried microorganisms can be improved by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt.

摘要翻译： 本发明涉及通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，包含干燥的微生物的组合物和L-精氨酸的酸性化合物来提高干燥的微生物如干燥的乳酸菌的储存稳定性的方法 氨基酸盐及其制备方法，以及在L-精氨酸酸性氨基酸盐存在下储存干燥的微生物的方法。 通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，可以提高干燥微生物的储存稳定性。

公开(公告)号：US20090082305A1

公开(公告)日：2009-03-26

申请号：US11909328

申请日：2006-03-30

申请人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

发明人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： A61K31/7084 ,  A61K31/34 ,  A23K1/16 ,  A23L1/48

CPC分类号： A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K31/375 ,  A61K31/7084

摘要： The present invention relates to a method of improving storage stability of reduced form of nicotinamide adenine dinucleotide, reduced form of nicotinamide adenine dinucleotide phosphate, or a salt thereof, or ascorbic acid, an ascorbic acid derivative, or a salt thereof, which comprises allowing the substance to coexist with an L-arginine acidic amino acid salt, a composition containing the substance and an L-arginine acidic amino acid salt, a process for producing the composition, and a method of storing the substance in the presence of an L-arginine acidic amino acid salt.

摘要翻译： 本发明涉及一种改善烟酰胺腺嘌呤二核苷酸，还原型烟酰胺腺嘌呤二核苷酸磷酸酯或其盐或抗坏血酸，抗坏血酸衍生物或其盐的还原形式的储存稳定性的方法，其包括使 物质与L-精氨酸酸性氨基酸盐共存，含有该物质和L-精氨酸酸性氨基酸盐的组合物，该组合物的制造方法以及在L-精氨酸存在下将物质进行存储的方法 酸性氨基酸盐。

公开(公告)号：US20060172005A1

公开(公告)日：2006-08-03

申请号：US10564438

申请日：2004-07-08

申请人： Takahiro Hara ,  Masao Kimura ,  Yasushi Sakai

发明人： Takahiro Hara ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： A61K31/724 ,  A61K9/20

CPC分类号： A61K9/0056 ,  A61K9/286 ,  A61K31/198 ,  A61K31/375

摘要： An object of the present invention relates to a tablet which comprises an active ingredient and a cyclodextrin or a cyclodextrin derivative and rapidly disintegrates in the oral cavity, etc. The present invention provides a tablet in which 70% by mass or more of the components of the tablet is a cyclodextrin or a cyclodextrin derivative and a method for manufacturing a tablet comprising the steps of: mixing constituent components of the tablet which comprises as constituent components an active ingredient and a cyclodextrin or a cyclodextrin derivative and in which 70% by mass or more of the total constituent components of the tablet is the cyclodextrin or the cyclodextrin derivative; and subsequently tableting the resultant mixture.

摘要翻译： 本发明的目的是涉及包含活性成分和环糊精或环糊精衍生物并在口腔内快速崩解的片剂等。本发明提供一种片剂，其中，70质量％以上的成分 片剂为环糊精或环糊精衍生物及其制备方法，其特征在于，包括以下步骤：将片剂的构成成分与作为活性成分的组合成分与环糊精或环糊精衍生物混合，将70质量％ 更多的片剂的总体构成成分是环糊精或环糊精衍生物; 随后将所得混合物压片。

公开(公告)号：US20070224265A1

公开(公告)日：2007-09-27

申请号：US11578061

申请日：2005-04-14

申请人： Takahiro Hara ,  Masao Kimura ,  Yasushi Sakai

发明人： Takahiro Hara ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： A61K9/20 ,  A61K31/198 ,  A61K47/26 ,  A61P13/12 ,  A61P25/20 ,  A61P9/10 ,  A61P3/10 ,  A61P21/06 ,  A61P1/16 ,  A61K47/38

CPC分类号： A61K31/198 ,  A61K9/2013 ,  A61K9/2018 ,  A61K47/183 ,  A61K47/26

摘要： According to the present invention, with an object to provide a tablet comprising a branched chain amino acid that can be produced without compression molding failures and a method for producing the same, provided are a tablet comprising a branched chain amino acid and hydrogenated palatinose, a method for producing a tablet comprising a branched chain amino acid in which a mixture of the branched chain amino acid and hydrogenated palatinose is compression-molded by direct tableting method, and a method for producing a tablet comprising a branched chain amino acid including a step of granulating a mixture comprising the branched chain amino acid and hydrogenated palatinose and a subsequent step of compression molding.

摘要翻译： 根据本发明，目的在于提供一种包含可压缩成型失败的支链氨基酸的片剂及其制造方法，其特征在于，含有支链氨基酸和氢化帕拉金糖的片剂， 制备包含支链氨基酸的片剂的方法，其中通过直接压片法将支链氨基酸和氢化帕拉金糖的混合物进行压缩成型，以及包含支链氨基酸的片剂的制备方法，包括步骤 造粒含有支链氨基酸和氢化帕拉金糖的混合物和随后的压缩成型步骤。

公开(公告)号：US07846902B2

公开(公告)日：2010-12-07

申请号：US12066849

申请日：2006-09-20

申请人： Yasushi Sakai ,  Masao Kimura ,  Shun Kayahashi ,  Toshikazu Kamiya ,  Shin-ichi Hashimoto ,  Hideo Kawabe

发明人： Yasushi Sakai ,  Masao Kimura ,  Shun Kayahashi ,  Toshikazu Kamiya ,  Shin-ichi Hashimoto ,  Hideo Kawabe

IPC分类号： A61K38/05 ,  A61K9/00

CPC分类号： A61K9/2095 ,  A23L2/39 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/2018 ,  A61K9/2059 ,  A61K38/05 ,  A23V2200/316 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/0626 ,  A23V2250/0604 ,  A23V2250/0622 ,  A23V2250/0606 ,  A23V2250/0642 ,  A23V2250/0608 ,  A23V2250/062

摘要： A composition for oral administration is provided, which includes at least one dipeptide represented by the formula: (wherein X represents alanyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property.

摘要翻译： 提供一种用于口服给药的组合物，其包括至少一种由下式表示的二肽（其中X表示丙氨酰，Y表示缬氨酸，亮氨酸或异亮氨酸），其目的是提供营养优异的口服组合物 ，药理作用和气味，或提供口服给药组合物，其加工特性如溶解度和压片性能优异。

公开(公告)号：US20090028937A1

公开(公告)日：2009-01-29

申请号：US11814828

申请日：2006-01-30

申请人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

发明人： Toshikazu Kamiya ,  Masao Kimura ,  Yasushi Sakai

IPC分类号： A61K9/20 ,  A61K31/195

CPC分类号： A61K9/2018 ,  A61K9/205 ,  A61K31/198

摘要： The present invention has an object to provide a tablet capable of comprising ornithine hydrochloride in a higher content; and a process for producing the same, and provides the tablet comprising ornithine hydrochloride and maltose, or a linear or cyclic dextrin; and the process for producing a tablet comprising ornithine hydrochloride, which comprises compression molding a mixture comprising ornithine hydrochloride and maltose, or a linear or cyclic dextrin by a direct tableting method.

摘要翻译： 本发明的目的是提供一种能够含有更高含量的鸟氨酸盐酸盐的片剂， 及其制备方法，提供包含鸟氨酸盐酸盐和麦芽糖的片剂，或线性或环状糊精; 以及包含鸟氨酸盐酸盐的片剂的制造方法，其包括通过直接压片法压缩成型含有鸟氨酸盐酸盐和麦芽糖的混合物，或线性或环状糊精。

公开(公告)号：US20080305151A1

公开(公告)日：2008-12-11

申请号：US12066849

申请日：2006-09-20

申请人： Yasushi Sakai ,  Masao Kimura ,  Shun Kayahashi ,  Toshikazu Kamiya ,  Shin-ichi Hashimoto ,  Hideo Kawabe

发明人： Yasushi Sakai ,  Masao Kimura ,  Shun Kayahashi ,  Toshikazu Kamiya ,  Shin-ichi Hashimoto ,  Hideo Kawabe

IPC分类号： A61K9/00 ,  C07C229/02 ,  A61K38/05

CPC分类号： A61K9/2095 ,  A23L2/39 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/2018 ,  A61K9/2059 ,  A61K38/05 ,  A23V2200/316 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/0626 ,  A23V2250/0604 ,  A23V2250/0622 ,  A23V2250/0606 ,  A23V2250/0642 ,  A23V2250/0608 ,  A23V2250/062

摘要： The present invention provides a composition for oral administration, which comprises at least one kind of dipeptide represented by the formula: X-Y (wherein X represents alanyl, glycyl, arginyl, seryl, α-aspartyl or α-glutamyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation and comprises at least one kind selected from valine, leucine and isoleucine, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property and comprises at least one kind selected from valine, leucine and isoleucine.

摘要翻译： 本发明提供了一种口服给药用组合物，其包含至少一种由下式表示的二肽：<？in-line-formula description =“In-line Formulas”end =“lead”？> XY < line-formula description =“In-line Formulas”end =“tail”？>（其中X表示丙氨酰，甘氨酰，精氨酰，丝氨酰，α-天冬氨酰或α-谷氨酰，Y表示缬氨酸，亮氨酸或异亮氨酸） 提供口服给药组合物的目的在营养，药理作用和阵风上优异，并且包含选自缬氨酸，亮氨酸和异亮氨酸的至少一种，或提供加工特性如溶解性和压片性优异的口服用组合物 性质并且包含选自缬氨酸，亮氨酸和异亮氨酸中的至少一种。

公开(公告)号：US09918951B2

公开(公告)日：2018-03-20

申请号：US12866001

申请日：2009-02-05

申请人： Yasushi Sakai ,  Shun Kayahashi

发明人： Yasushi Sakai ,  Shun Kayahashi

IPC分类号： A61K9/00 ,  A61K31/198 ,  A61K9/14 ,  A61K47/12 ,  A61K47/18 ,  A23L33/10 ,  A23L33/175

CPC分类号： A61K31/198 ,  A23L33/10 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/145 ,  A61K47/12 ,  A61K47/183 ,  A23V2200/02 ,  A23V2250/31 ,  A23V2250/0606 ,  A23V2250/063 ,  A23V2250/032 ,  A23V2250/056 ,  A23V2250/044 ,  A23V2250/708

摘要： The invention provides a method of improving the preservation stability of glutathione in a solid composition containing glutathione and arginine. In particular, glutathione and arginine are made to be coexistent with an organic acid such as citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to coexistent with glutathione and arginine is generally 0.1-2 parts by weight relative to 1 part by weight of arginine.