知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

59 条记录 (耗时 0.056 秒)

    Quinazolinone compounds as anticancer agents
    2.
    发明授权
    Quinazolinone compounds as anticancer agents 失效
    喹唑啉酮化合物作为抗癌剂

    公开(公告)号：US07939539B2

    公开(公告)日：2011-05-10

    申请号：US10996814

    申请日：2004-11-24

    申请人： Weibo Wang ,  Liana M. Lagniton ,  Ryan N. Constantine ,  Manoj C. Desai

    发明人： Weibo Wang ,  Liana M. Lagniton ,  Ryan N. Constantine ,  Manoj C. Desai

    IPC分类号： A61K31/517 ,  C07D239/88

    CPC分类号： C07D401/06 ,  C07D239/90

    摘要： Quinazolinone compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

    摘要翻译： 喹唑啉酮化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种喹唑啉酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用喹唑啉酮化合物或与至少一种其它治疗剂组合使用的方法可用于预防或治疗增殖性疾病。

    ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF
    7.
    发明申请
    ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20090291922A1

    公开(公告)日：2009-11-26

    申请号：US12436004

    申请日：2009-05-05

    申请人： Xiaoqin Cheng ,  Gary P. Cook ,  Manoj C. Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung U. Kim ,  William A. Lee ,  John C. Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    发明人： Xiaoqin Cheng ,  Gary P. Cook ,  Manoj C. Desai ,  Edward Doerffler ,  Gong-Xin He ,  Choung U. Kim ,  William A. Lee ,  John C. Rohloff ,  Jianying Wang ,  Zheng-Yu Yang

    IPC分类号： A61K31/675 ,  C07D473/16 ,  A61K31/52 ,  C07F9/02

    CPC分类号： C07F9/65616 ,  Y02P20/55

    摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, —N(R4)C(R3b) (N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.

    Spiroazacyclic derivatives as substance P antagonists
    10.
    发明授权
    Spiroazacyclic derivatives as substance P antagonists 失效
    作为物质P拮抗剂的螺环环衍生物

    公开(公告)号：US5688806A

    公开(公告)日：1997-11-18

    申请号：US513798

    申请日：1995-10-12

    申请人： Manoj C. Desai ,  Lawrence A. Vincent

    发明人： Manoj C. Desai ,  Lawrence A. Vincent

    IPC分类号： A61K31/435 ,  A61P25/00 ,  A61P25/04 ,  A61P25/30 ,  A61P29/00 ,  C07D211/76 ,  C07D471/10 ,  A61K31/445

    CPC分类号： C07D471/10 ,  C07D211/76

    摘要： The present invention relates to novel spirocyclic piperidine derivatives and related compounds and, specifically, to compounds of the formula ##STR1## wherein X, Z, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and m are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

    摘要翻译： PCT No.PCT / US93 / 11793 Sec。 371 1995年10月12日第 102（e）日期1995年10月12日PCT 1993年12月10日PCT PCT。 第WO94 / 20500号公报 日期1994年9月15日本发明涉及新型的螺环哌啶衍生物和相关化合物，具体地说，涉及式m化合物如本说明书中所定义，以及用于合成这些化合物的中间体。 式I的新型化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。