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    Method for modifying the refractive index of ocular tissues
    4.
    发明授权
    Method for modifying the refractive index of ocular tissues 有权
    改变眼组织折射率的方法

    公开(公告)号：US08617147B2

    公开(公告)日：2013-12-31

    申请号：US12895978

    申请日：2010-10-01

    申请人： Wayne H. Knox ,  Krystel R. Huxlin

    发明人： Wayne H. Knox ,  Krystel R. Huxlin

    IPC分类号： A61B18/18

    CPC分类号： A61F9/00829 ,  A61F9/008 ,  A61F9/00827 ,  A61F2009/00842 ,  A61F2009/00851 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00897

    摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.

    摘要翻译： 一种用于向患者提供视力矫正的方法。 该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织 焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。 此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

    Method for modifying the refractive index of ocular tissues and applications thereof
    5.
    发明授权
    Method for modifying the refractive index of ocular tissues and applications thereof 有权

    公开(公告)号：US10813791B2

    公开(公告)日：2020-10-27

    申请号：US13326403

    申请日：2011-12-15

    申请人： Wayne H. Knox ,  Krystel R. Huxlin

    发明人： Wayne H. Knox ,  Krystel R. Huxlin

    IPC分类号： A61F9/008

    摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

    METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES AND APPLICATIONS THEREOF
    6.
    发明申请
    METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES AND APPLICATIONS THEREOF 审中-公开
    用于修改眼科组织折射指数的方法及其应用

    公开(公告)号：US20120310223A1

    公开(公告)日：2012-12-06

    申请号：US13326403

    申请日：2011-12-15

    申请人： Wayne H. Knox ,  Krystel R. Huxlin

    发明人： Wayne H. Knox ,  Krystel R. Huxlin

    IPC分类号： A61F9/01

    CPC分类号： A61F9/00827 ,  A61F9/00834 ,  A61F2009/00842 ,  A61F2009/00846 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/0088

    摘要： A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

    摘要翻译： 一种通过在角膜基质和/或晶体中产生至少一个光学修饰的梯度指数（GRIN）层来连续地扫描具有聚焦体积的激光脉冲的流量来修改眼睛中眼组织的折射特性的方法， 具有在组织内具有平滑变化的折射率的连续线具有已知平均功率的激光，并且在扫描期间改变扫描速度和激光平均功率中的任一者或两者。 该方法还可以包括确定期望的视力矫正调整，以及确定要在眼组织内产生的梯度指数（GRIN）层的位置，数量和设计参数，以提供期望的视力矫正。

    METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES
    7.
    发明申请
    METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES 有权
    修饰眼科组织折射指数的方法

    公开(公告)号：US20110071509A1

    公开(公告)日：2011-03-24

    申请号：US12895978

    申请日：2010-10-01

    申请人： Wayne H. Knox ,  Krystel R. Huxlin

    发明人： Wayne H. Knox ,  Krystel R. Huxlin

    IPC分类号： A61F9/01

    CPC分类号： A61F9/00829 ,  A61F9/008 ,  A61F9/00827 ,  A61F2009/00842 ,  A61F2009/00851 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00897

    摘要： A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.

    摘要翻译： 一种用于向患者提供视力矫正的方法。 该方法包括：（a）测量患者所需的视力矫正度，并确定需要定位在角膜内的折射结构的位置和形状，以部分校正患者的视力; （b）以足够高的强度将飞秒激光脉冲引导和聚焦在角膜内的蓝色光谱区域，以改变焦点区域内的角膜的折射率，但不足以破坏角膜或影响角膜外部的角膜组织 焦点区域; 和（c）扫描角膜或透镜体积上的激光脉冲，以在角膜或透镜中提供焦点区域的折射结构。 此外，折射结构的特征在于折射率的变化，并且表现出很少或没有散射损失。

    Method for Modifying the Refractive Index of an Optical Material and Resulting Optical Vision Component
    9.
    发明申请
    Method for Modifying the Refractive Index of an Optical Material and Resulting Optical Vision Component 有权
    用于修改光学材料和所得光学视觉组件的折射率的方法

    公开(公告)号：US20120310340A1

    公开(公告)日：2012-12-06

    申请号：US13238143

    申请日：2011-09-21

    申请人： Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

    发明人： Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

    IPC分类号： A61F2/16 ,  B29D11/00

    CPC分类号： G02B3/0087 ,  A61F2/1618 ,  A61F2/1627 ,  A61F9/00834 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/18 ,  A61L2430/16 ,  G02B2003/0093 ,  G02C2202/12 ,  G02C2202/14 ,  C08L33/10

    摘要： A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

    摘要翻译： 一种用于改变光学聚合物材料的折射率的方法。 该方法包括用飞秒激光脉冲连续照射光学聚合材料的预定区域，以在材料内形成梯度折射率折射结构。 光学装置包括具有前表面和后表面的光学聚合物透镜材料和与表面相交的光轴以及设置在前表面和后表面之间并且沿着第一轴线45布置的至少一个激光修饰的GRIN层 °至90°，并且进一步的特征在于，相邻段的至少一部分中的至少一个和沿着每个段的折射率的变化。

    OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX
    10.
    发明申请
    OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX 有权
    光学材料和修正折射指数的方法

    公开(公告)号：US20090143858A1

    公开(公告)日：2009-06-04

    申请号：US11948298

    申请日：2007-11-30

    申请人： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

    发明人： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

    IPC分类号： A61F2/16 ,  G02B1/12

    CPC分类号： A61F2/1613 ,  A61B18/20 ,  A61F2/14 ,  A61F2/16 ,  A61F2/1627 ,  A61F2/1635 ,  B29D11/00461 ,  B29D11/023 ,  C08J7/12 ,  C08J7/123 ,  G02C2202/14

    摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.

    摘要翻译： 用于改变光学聚合物材料的折射率的方法。 该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。 照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。 该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。 本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异 光学，聚合材料。