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1.发明公开公开(公告)号：US20230356109A1
公开(公告)日：2023-11-09
申请号：US18024628
申请日：2021-09-28
IPC分类号： B01D15/22 , B01D15/38 , B01D69/14 , B01D71/36 , B01D63/08 , B01D63/10 , B01D63/06 , B01J20/28 , B01J20/286 , B01J20/10 , B01J20/32
CPC分类号： B01D15/22 , B01D15/3809 , B01D69/147 , B01D71/36 , B01D63/082 , B01D63/10 , B01D63/06 , B01J20/28019 , B01J20/28038 , B01J20/28004 , B01J20/286 , B01J20/10 , B01J20/321 , B01J20/3274 , B01J20/3291 , B01D2325/12 , B01D2323/12 , B01D2319/04
摘要： The present disclosure is directed to affinity chromatography devices including a fibrillated polymer membrane that contains inorganic particles having a spherical shape and a particle size distribution that has a D90/D10 less than or equal to 3. A blend or a combination of spherical inorganic particles may be utilized. A nominal particle size of the spherical inorganic particles is from about 5 microns to about 20 microns. An affinity ligand may be bonded to the spherical inorganic particles and/or to the fibrillated polymer membrane. Also, the affinity chromatography devices have a hydraulic permeability from about 100 (×10−12 cm2) to about 500 (×10−12 cm2). Additionally, the affinity chromatography devices have a cycling durability of at least 100 cycles without exceeding an pressure of 0.3 MPa. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
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公开(公告)号：US20230241530A1
公开(公告)日：2023-08-03
申请号：US17590338
申请日：2022-02-01
发明人： Jared Clinger , EuiJun Kim , Kevin Mabe , Michael McManaway , Eric Van Voorhees , Jeffrey Cassel , Edward Gunzel
CPC分类号： B01D15/3804 , B01D61/38 , B01J20/165 , B01J20/041 , B01J20/043
摘要： The present disclosure is directed to affinity chromatography devices that include a fibrillated heat treated polymer membrane that contains therein inorganic particles that separate a targeted molecule from an aqueous mixture containing the targeted molecule. The targeted molecule includes proteins, antibodies, viral vectors, nucleic acids, and combinations thereof. The inorganic particles may be spherical or irregular in shape. A blend or combination of various sizes and/or shapes of inorganic particles may be utilized. An affinity ligand may be bonded to the inorganic particles and/or to the fibrillated polymer membrane. The affinity chromatography device may be repeatedly used and may be cleaned between uses. In some embodiments, the affinity chromatography devices separate nucleic acids (e.g., mRNA) and viral vectors (e.g., adeno-associated virus) from the aqueous mixture. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
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公开(公告)号：US20230241529A1
公开(公告)日：2023-08-03
申请号：US17590335
申请日：2022-02-01
发明人： Jared Clinger , EuiJun Kim , Kevin Mabe , Michael McManaway , Eric Van Voorhees , Jeffrey Cassel , Edward Gunzel
CPC分类号： B01D15/3804 , B01D61/38 , B01J20/165 , B01J20/041 , B01J20/043
摘要： The present disclosure is directed to affinity chromatography devices that include a fibrillated polymer membrane that contains therein inorganic particles that separate a targeted molecule from an aqueous mixture containing the targeted molecule. The targeted molecule includes proteins, antibodies, viral vectors, nucleic acids, and combinations thereof. The inorganic particles may be spherical or irregular in shape. A blend or combination of various sizes and/or shapes of inorganic particles may be utilized. An affinity ligand may be bonded to the inorganic particles and/or to the fibrillated polymer membrane. The affinity chromatography device may be repeatedly used and may be cleaned between uses. In some embodiments, the affinity chromatography devices separate nucleic acids (e.g., mRNA) and viral vectors (e.g., adeno-associated virus) from the aqueous mixture. Manifolds containing multiple affinity chromatography devices in a parallel configuration and multiple manifolds in a parallel configuration are also disclosed.
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