公开(公告)号：US20230286961A1

公开(公告)日：2023-09-14

申请号：US17982983

申请日：2022-11-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia M. Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07D307/24

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11919887B2

公开(公告)日：2024-03-05

申请号：US17982983

申请日：2022-11-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia M. Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D307/24 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11827627B2

公开(公告)日：2023-11-28

申请号：US17831842

申请日：2022-06-03

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Elizabeth Mary Beck ,  Steven John Durrant ,  Sarah Skerratt ,  Robert Pullin ,  Gorka Etxebarria Jardi ,  David Matthew Shaw ,  Nadia M. Ahmad ,  Christopher Wray ,  Anisa Nizarali Virani ,  Kiri North ,  James Dodd ,  Michael Edward O'Donnell ,  Bhairavi Galan ,  Ronald Marcellus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  Stephen Andrew Thomson ,  Lidio Marx Carvalho Meireles ,  Dean Stamos ,  Yvonne Schmidt ,  Joseph Pontillo ,  Sara S. Hadida Ruah ,  Timothy Donald Neubert ,  Dennis James Hurley ,  Jinglan Zhou

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20240182455A1

公开(公告)日：2024-06-06

申请号：US18491021

申请日：2023-10-20

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Elizabeth Mary Beck ,  Steven John Durrant ,  Sarah Skerratt ,  Robert Pullin ,  Gorka Etxebarria Jardi ,  David Matthew Shaw ,  Nadia M. Ahmad ,  Christopher Wray ,  Anisa Nizarali Virani ,  Kiri North ,  James Dodd ,  Michael Edward O'Donnell ,  Bhairavi Galan ,  Ronald Marcellus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  Stephen Andrew Thomson ,  Lidio Marx Carvalho Meireles ,  Dean Stamos ,  Yvonne Schmidt ,  Joseph Pontillo ,  Sara S. Hadida Ruah ,  Timothy Donald Neubert ,  Dennis James Hurley ,  Jinglan Zhou

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11834441B2

公开(公告)日：2023-12-05

申请号：US17112156

申请日：2020-12-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20130338119A1

公开(公告)日：2013-12-19

申请号：US13967732

申请日：2013-08-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Dean Stamos ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Timothy Donald Neubert ,  Mehdi Numa ,  Tara Whitney ,  Aarti Sameer Kawatkar

IPC分类号： C07D417/14

CPC分类号： C07D417/14

摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：US08492403B2

公开(公告)日：2013-07-23

申请号：US13745919

申请日：2013-01-21

申请人： Vertex Pharmaceuticals Incorporated

发明人： Aarti Sameer Kawatkar ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Andreas P. Termin ,  Timothy Donald Neubert

IPC分类号： C07D401/12

CPC分类号： C07D417/12 ,  C07D277/52

摘要： Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.

公开(公告)号：US20230382910A1

公开(公告)日：2023-11-30

申请号：US18305186

申请日：2023-04-21

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Mark Thomas Miller ,  Dennis James Hurley ,  Timothy Donald Neubert ,  Elamprakash Nesan Savariar ,  Urvi Patel ,  Sara Sabina Hadida Ruah ,  Jason McCartney ,  Jinglan Zhou ,  Robert Martin Demoret ,  Roman Askatovich Valiulin ,  Alexander Frederik Kintzer ,  Peter Webb ,  David Robert Slochower ,  Kathleen Aertgeerts ,  Elizabeth Mary Beck ,  Ronald Marcellus Alphonsus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder

IPC分类号： C07D471/04 ,  C07D215/233 ,  C07D215/22 ,  C07D215/60 ,  C07D215/48 ,  C07D401/04

CPC分类号： C07D471/04 ,  C07D215/233 ,  C07D215/22 ,  C07D215/60 ,  C07D215/48 ,  C07D401/04

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20230373925A1

公开(公告)日：2023-11-23

申请号：US18137939

申请日：2023-04-21

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Mark Thomas Miller ,  Dennis James Hurley ,  Timothy Donald Neubert ,  Vijayalaksmi Arumugam ,  Sara Sabina Hadida Ruah ,  Jason McCartney ,  Jinglan ZHOU ,  Jaclyn Chau ,  Robert Martin Demoret ,  Senait G. Ghirmai ,  Roman Askatovich Valiulin ,  Alexander Frederik Kintzer ,  David Robert Slochower ,  Kathleen Aertgeerts ,  Elizabeth Mary Beck ,  James Jun Bon Mui ,  Miranda Adele Wright ,  Ronald Marcellus Alphonsus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  James Dodd

IPC分类号： C07D215/233 ,  C07D471/04 ,  C07D239/91 ,  C07D401/14 ,  C07D401/04 ,  C07D519/00

CPC分类号： C07D215/233 ,  C07D471/04 ,  C07D239/91 ,  C07D401/14 ,  C07D401/04 ,  C07D519/00 ,  C07B2200/05

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US08841282B2

公开(公告)日：2014-09-23

申请号：US13967732

申请日：2013-08-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Dean Stamos ,  Esther Ann Martinborough ,  Nicole Hilgraf ,  Timothy Donald Neubert ,  Mehdi Numa ,  Tara Whitney ,  Aarti Sameer Kawatkar

IPC分类号： C07D417/14

CPC分类号： C07D417/14

摘要： The present invention relates to pyrrolidinone benzenesulfonamides of the following formula: useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

摘要翻译： 本发明涉及下式的吡咯烷酮苯磺酰胺：可用作离子通道的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。