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公开(公告)号：US11919887B2
公开(公告)日：2024-03-05
申请号：US17982983
申请日：2022-11-08
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Steven John Durrant , Nadia M. Ahmad , Elizabeth Mary Beck , Lidio Marx Carvalho Meireles , Ewa Iwona Chudyk , Gorka Etxebarria Jardi , Bhairavi Galan , Sara S. Hadida Ruah , Dennis James Hurley , Ronald Marcellus Knegtel , Timothy Donald Neubert , Joanne Louise Pinder , Joseph Pontillo , Robert Pullin , Yvonne Schmidt , David Matthew Shaw , Sarah Skerratt , Dean Stamos , Stephen Andrew Thomson , Anisa Nizarali Virani , Christopher Wray
IPC: C07D307/24 , C07D405/12 , C07D405/14
CPC classification number: C07D405/12 , C07D307/24 , C07D405/14 , C07B2200/13
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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2.发明授权公开(公告)号：US11827627B2
公开(公告)日：2023-11-28
申请号：US17831842
申请日：2022-06-03
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Elizabeth Mary Beck , Steven John Durrant , Sarah Skerratt , Robert Pullin , Gorka Etxebarria Jardi , David Matthew Shaw , Nadia M. Ahmad , Christopher Wray , Anisa Nizarali Virani , Kiri North , James Dodd , Michael Edward O'Donnell , Bhairavi Galan , Ronald Marcellus Knegtel , Ewa Iwona Chudyk , Joanne Louise Pinder , Stephen Andrew Thomson , Lidio Marx Carvalho Meireles , Dean Stamos , Yvonne Schmidt , Joseph Pontillo , Sara S. Hadida Ruah , Timothy Donald Neubert , Dennis James Hurley , Jinglan Zhou
IPC: C07D405/12
CPC classification number: C07D405/12
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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3.发明公开公开(公告)号：US20240182455A1
公开(公告)日：2024-06-06
申请号：US18491021
申请日：2023-10-20
Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Inventor： Elizabeth Mary Beck , Steven John Durrant , Sarah Skerratt , Robert Pullin , Gorka Etxebarria Jardi , David Matthew Shaw , Nadia M. Ahmad , Christopher Wray , Anisa Nizarali Virani , Kiri North , James Dodd , Michael Edward O'Donnell , Bhairavi Galan , Ronald Marcellus Knegtel , Ewa Iwona Chudyk , Joanne Louise Pinder , Stephen Andrew Thomson , Lidio Marx Carvalho Meireles , Dean Stamos , Yvonne Schmidt , Joseph Pontillo , Sara S. Hadida Ruah , Timothy Donald Neubert , Dennis James Hurley , Jinglan Zhou
IPC: C07D405/12
CPC classification number: C07D405/12
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US11834441B2
公开(公告)日：2023-12-05
申请号：US17112156
申请日：2020-12-04
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Steven John Durrant , Nadia Ahmad , Elizabeth Mary Beck , Lidio Marx Carvalho Meireles , Ewa Iwona Chudyk , Gorka Etxebarria Jardi , Bhairavi Galan , Sara S. Hadida Ruah , Dennis James Hurley , Ronald Marcellus Knegtel , Timothy Donald Neubert , Joanne Louise Pinder , Joseph Pontillo , Robert Pullin , Yvonne Schmidt , David Matthew Shaw , Sarah Skerratt , Dean Stamos , Stephen Andrew Thomson , Anisa Nizarali Virani , Christopher Wray
IPC: C07D405/12 , C07D307/24 , C07D405/14
CPC classification number: C07D405/12 , C07D307/24 , C07D405/14 , C07B2200/13
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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Patent Agency Ranking
5.发明申请公开(公告)号：US20130338119A1
公开(公告)日：2013-12-19
申请号：US13967732
申请日：2013-08-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Stamos , Esther Ann Martinborough , Nicole Hilgraf , Timothy Donald Neubert , Mehdi Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC: C07D417/14
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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6.发明授权公开(公告)号：US08586589B2
公开(公告)日：2013-11-19
申请号：US13633478
申请日：2012-10-02
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC: A61K31/497 , A61K31/445
CPC classification number: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
Abstract translation: 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US20240391907A1
公开(公告)日：2024-11-28
申请号：US18524339
申请日：2023-11-30
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Steven John Durrant , Nadia M. Ahmad , Elizabeth Mary Beck , Lidio Marx Carvalho Meireles , Ewa Iwona Chudyk , Gorka Etxebarria Jardi , Bhairavi Galan , Sara S. Hadida Ruah , Dennis James Hurley , Ronald Marcellus Knegtel , Timothy Donald Neubert , Joanne Louise Pinder , Joseph Pontillo , Robert Pullin , Yvonne Schmidt , David Matthew Shaw , Sarah Skerratt , Dean Stamos , Stephen Andrew Thomson , Anisa Nizarali Virani , Christopher Wray
IPC: C07D405/12 , C07D307/24 , C07D405/14
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20230286961A1
公开(公告)日：2023-09-14
申请号：US17982983
申请日：2022-11-08
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Steven John Durrant , Nadia M. Ahmad , Elizabeth Mary Beck , Lidio Marx Carvalho Meireles , Ewa Iwona Chudyk , Gorka Etxebarria Jardi , Bhairavi Galan , Sara S. Hadida Ruah , Dennis James Hurley , Ronald Marcellus Knegtel , Timothy Donald Neubert , Joanne Louise Pinder , Joseph Pontillo , Robert Pullin , Yvonne Schmidt , David Matthew Shaw , Sarah Skerratt , Dean Stamos , Stephen Andrew Thomson , Anisa Nizarali Virani , Christopher Wray
IPC: C07D405/12 , C07D405/14 , C07D307/24
CPC classification number: C07D405/12 , C07D307/24 , C07D405/14 , C07B2200/13
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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9.发明授权公开(公告)号：US08841282B2
公开(公告)日：2014-09-23
申请号：US13967732
申请日：2013-08-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Dean Stamos , Esther Ann Martinborough , Nicole Hilgraf , Timothy Donald Neubert , Mehdi Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC: C07D417/14
CPC classification number: C07D417/14
Abstract: The present invention relates to pyrrolidinone benzenesulfonamides of the following formula: useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
Abstract translation: 本发明涉及下式的吡咯烷酮苯磺酰胺：可用作离子通道的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。
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