公开(公告)号：US20230374038A1

公开(公告)日：2023-11-23

申请号：US18248068

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy Richard COON ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Haripada KHATUYA ,  Paul KRENITSKY ,  Mark Thomas MILLER ,  Prasuna PARASELLI ,  Fabrice PIERRE ,  Alina SILINA ,  Joe A. TRAN ,  Jinglan ZHOU

IPC分类号： C07D515/08 ,  A61K45/06 ,  C07D515/18 ,  A61K31/529 ,  A61K31/5377

CPC分类号： C07D515/08 ,  A61K45/06 ,  C07D515/18 ,  A61K31/529 ,  A61K31/5377

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of mediated diseases, such as cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and therapies comprising such modulators, and processes and intermediates for making such modulators.

公开(公告)号：US20230416275A1

公开(公告)日：2023-12-28

申请号：US18030537

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Mark Thomas MILLER ,  Alina SILINA ,  Jinglan ZHOU

IPC分类号： C07D515/18 ,  C07D515/22 ,  C07D515/08 ,  A61K45/06

CPC分类号： C07D515/18 ,  C07D515/22 ,  C07D515/08 ,  A61K45/06 ,  C07B2200/09

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：US20230373939A1

公开(公告)日：2023-11-23

申请号：US18030519

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Mark Thomas MILLER ,  Alina SILINA ,  Jinglan ZHOU

IPC分类号： C07D279/06 ,  C07D241/22 ,  C07D251/24 ,  C07D239/69 ,  C07D403/04 ,  C07D213/76 ,  C07D401/14 ,  C07D401/12 ,  A61K45/06

CPC分类号： C07D279/06 ,  C07D241/22 ,  C07D251/24 ,  C07D239/69 ,  C07D403/04 ,  C07D213/76 ,  C07D401/14 ,  C07D401/12 ,  A61K45/06 ,  C07B2200/05

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：US20240150377A1

公开(公告)日：2024-05-09

申请号：US18248071

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy Richard COON ,  Timothy A. DWIGHT ,  Lev Tyler Dewey FANNING ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Anton V. GULEVICH ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Haripada KHATUYA ,  Paul KRENITSKY ,  Vito MELILLO ,  Mark Thomas MILLER ,  Prasuna PARASELLI ,  Fabrice PIERRE ,  Alina SILINA ,  Joe A. TRAN ,  Johnny UY ,  Lino VALDEZ ,  Troy VICKERS ,  Jinglan ZHOU

IPC分类号： C07D515/08 ,  A61K31/404 ,  A61K31/47 ,  A61K31/529

CPC分类号： C07D515/08 ,  A61K31/404 ,  A61K31/47 ,  A61K31/529

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

公开(公告)号：US20230382924A1

公开(公告)日：2023-11-30

申请号：US18030527

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Paul KRENITSKY ,  Mark Thomas MILLER ,  Fabrice PIERRE ,  Alina SILINA ,  Johnny UY ,  Jinglan Zhou

IPC分类号： C07D515/08 ,  C07F7/08 ,  C07F9/6561 ,  C07D515/18 ,  C07D515/20 ,  C07D519/00 ,  A61K31/47 ,  A61K31/529 ,  A61K31/695 ,  A61K31/675 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D515/08 ,  C07F7/0812 ,  C07F9/6561 ,  C07D515/18 ,  C07D515/20 ,  C07D519/00 ,  A61K31/47 ,  A61K31/529 ,  A61K31/695 ,  A61K31/675 ,  A61K31/5377 ,  A61K31/541 ,  C07B2200/09

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：US20220372047A1

公开(公告)日：2022-11-24

申请号：US17600829

申请日：2020-04-02

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Paul KRENITSKY ,  Jason MCCARTNEY ,  Vito MELILLO ,  Mark Thomas MILLER ,  Alina SILINA ,  Johnny UY ,  Jinglan ZHOU

IPC分类号： C07D515/08 ,  C07D239/69 ,  C07D215/233 ,  C07D405/12

摘要： Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

公开(公告)号：US20240018161A1

公开(公告)日：2024-01-18

申请号：US18030530

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy Richard COON ,  Andrew DINH ,  Timothy A. DWIGHT ,  Lev Tyler Dewey FANNING ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Paul KRENITSKY ,  Mark Thomas MILLER ,  Fabrice PIERRE ,  Alina SILINA ,  Joe A. TRAN ,  Lino VALDEZ ,  Jinglan ZHOU

IPC分类号： C07D515/04 ,  C07D515/14 ,  A61K45/06

CPC分类号： C07D515/04 ,  A61K45/06 ,  C07D515/14

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：US20230373935A1

公开(公告)日：2023-11-23

申请号：US18030518

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Mark Thomas MILLER ,  Alina SILINA ,  Jinglan ZHOU

IPC分类号： C07D239/69 ,  C07D401/14 ,  C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/12 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D471/08 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D413/10 ,  C07F9/6558 ,  C07D409/12 ,  C07D405/12 ,  C07D239/47 ,  C07D413/12 ,  C07D417/12 ,  A61K45/06

CPC分类号： C07D239/69 ,  C07D401/14 ,  C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/12 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D471/08 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D413/10 ,  C07F9/65583 ,  C07D409/12 ,  C07D405/12 ,  C07D239/47 ,  C07D413/12 ,  C07D417/12 ,  A61K45/06

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.

公开(公告)号：US20230382925A1

公开(公告)日：2023-11-30

申请号：US18030529

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Alexander Russell ABELA ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Jeremy CLEMENS ,  Thomas CLEVELAND ,  Timothy Richard COON ,  Timothy A. DWIGHT ,  Lev Tyler Dewey FANNING ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Anton V. GULEVICH ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Haripada KHATUYA ,  Paul KRENITSKY ,  Vito MELILLO ,  Mark Thomas MILLER ,  Prasuna PARASELLI ,  Fabrice PIERRE ,  Alina SILINA ,  Joe A. TRAN ,  Johnny UY ,  Lino VALDEZ ,  Jinglan ZHOU

IPC分类号： C07D515/08 ,  A61K45/06

CPC分类号： C07D515/08 ,  A61K45/06

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：US20230373974A1

公开(公告)日：2023-11-23

申请号：US18030520

申请日：2021-10-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Jason MCCARTNEY ,  Sunny ABRAHAM ,  Corey Don ANDERSON ,  Vijayalaksmi ARUMUGAM ,  Jaclyn CHAU ,  Thomas CLEVELAND ,  Timothy A. DWIGHT ,  Bryan A. FRIEMAN ,  Peter GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Mark Thomas MILLER ,  Alina SILINA ,  Jinglan ZHOU

IPC分类号： C07D403/12 ,  C07D239/70 ,  C07D279/08 ,  C07D241/44 ,  C07D471/04 ,  C07D277/82 ,  C07D513/04 ,  C07D277/84 ,  C07D239/84 ,  C07D487/04 ,  C07D231/56 ,  C07D215/38 ,  C07D217/22 ,  C07D491/048 ,  C07D235/30 ,  A61K45/06

CPC分类号： C07D403/12 ,  C07D239/70 ,  C07D279/08 ,  C07D241/44 ,  C07D471/04 ,  C07D277/82 ,  C07D513/04 ,  C07D277/84 ,  C07D239/84 ,  C07D487/04 ,  C07D231/56 ,  C07D215/38 ,  C07D217/22 ,  C07D491/048 ,  C07D235/30 ,  A61K45/06

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions, containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.