公开(公告)号：US20240180924A1

公开(公告)日：2024-06-06

申请号：US18526158

申请日：2023-12-01

Applicant: Newave Pharmaceutical Inc.

Inventor： Yi Chen

IPC: A61K31/553 ,  A61K31/282 ,  A61K31/4184 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/52 ,  A61K31/635 ,  A61K31/7048 ,  A61K33/243 ,  A61K35/17 ,  A61K38/07 ,  A61K39/395 ,  A61K47/68 ,  A61P35/02 ,  C07D471/14 ,  C07D491/147 ,  C07D498/14 ,  C07D498/22 ,  C07D513/14 ,  C07D515/14 ,  C07D519/00

CPC classification number: A61K31/553 ,  A61K31/282 ,  A61K31/4184 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/52 ,  A61K31/635 ,  A61K31/7048 ,  A61K33/243 ,  A61K35/17 ,  A61K38/07 ,  A61K39/3955 ,  A61K47/6849 ,  A61P35/02 ,  C07D471/14 ,  C07D491/147 ,  C07D498/14 ,  C07D498/22 ,  C07D513/14 ,  C07D515/14 ,  C07D519/00

Abstract: The disclosure includes compounds of Formula (A), (A) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11, h, j m, n, k, v, s, g, V, W, L, Z1, Q1, Q2, Q3, Q4, Q5, Q6 and Q7, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a nerodegenerative disease with these compounds.

公开(公告)号：US11932658B2

公开(公告)日：2024-03-19

申请号：US17142288

申请日：2021-01-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D491/04 ,  A61K31/498 ,  A61P7/02 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D515/14 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and Ri, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20210188914A1

公开(公告)日：2021-06-24

申请号：US17185658

申请日：2021-02-25

Applicant: The Johns Hopkins University

Inventor： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC: C07K7/64 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US10954273B2

公开(公告)日：2021-03-23

申请号：US16563633

申请日：2019-09-06

Applicant: The Johns Hopkins University

Inventor： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC: C07K7/64 ,  C07K17/08 ,  G01N33/566 ,  A61K31/436 ,  A61K31/4353 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US20190315774A1

公开(公告)日：2019-10-17

申请号：US16317258

申请日：2017-07-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： XIAOJUN Zhang ,  Eldon Scott Priestley ,  Oz Scott Halpern ,  Wen Jiang ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D519/00 ,  A61P7/02 ,  C07D515/14

Abstract: Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US4876251A

公开(公告)日：1989-10-24

申请号：US59951

申请日：1987-06-09

Applicant: Akira Morimoto ,  Nobuo Choh ,  Noriyoshi Noguchi

Inventor： Akira Morimoto ,  Nobuo Choh ,  Noriyoshi Noguchi

IPC: A61K31/397 ,  A61K31/425 ,  A61K31/54 ,  A61P31/04 ,  C07D205/08 ,  C07D205/09 ,  C07D205/095 ,  C07D307/32 ,  C07D405/12 ,  C07D513/14 ,  C07D515/14

CPC classification number: C07D405/12 ,  C07D205/09 ,  C07D205/095 ,  C07D513/14

Abstract: The compounds, having a 4,10-dioxo-3-oxa-7-thia-1-azatricyclo[6,2,0,0.sup.2,6 ]decane-2-carboxylic acid skeleton as the base structure, their esters and their salts, are useful antibacterial agents.

公开(公告)号：US20240262867A1

公开(公告)日：2024-08-08

申请号：US18435939

申请日：2024-02-07

Applicant: The Johns Hopkins University

Inventor： Jun O. Liu ,  Jingxin Wang ,  Zufeng Guo ,  Wei Li ,  Shridhar Bhat ,  Manisha Das

IPC: C07K7/64 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

CPC classification number: C07K7/645 ,  A61K31/4353 ,  A61K31/436 ,  C07D471/04 ,  C07D498/04 ,  C07D498/14 ,  C07D515/04 ,  C07D515/14 ,  C07K17/08 ,  G01N33/566

Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

公开(公告)号：US20230076319A1

公开(公告)日：2023-03-09

申请号：US17937841

申请日：2022-10-04

Applicant: ANTIOS THERAPEUTICS, INC.

Inventor： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Davide GORNATI ,  Alessandro GRILLO ,  Luca FERRANTE ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Marco FERRARA

IPC: A61K31/554 ,  A61P31/20 ,  A61K31/407 ,  C07D513/14 ,  C07D515/08 ,  C07D515/14 ,  C07D519/00

Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.

公开(公告)号：US20220110943A1

公开(公告)日：2022-04-14

申请号：US17267693

申请日：2019-08-09

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE Dl GENETICA MOLECOLARE - INGM

Inventor： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Davide GORNATI ,  Alessandro GRILLO ,  Luca FERRANTE ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Marco FERRARA

IPC: A61K31/554 ,  C07D515/14 ,  C07D515/08 ,  A61K31/407 ,  C07D519/00 ,  C07D513/14 ,  A61P31/20

Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.

公开(公告)号：US11193891B2

公开(公告)日：2021-12-07

申请号：US16722988

申请日：2019-12-20

Applicant: Robert Bosch GmbH

Inventor： Mordechai Kornbluth ,  Kaushal Sagar ,  Jonathan Mailoa ,  Soo Kim

IPC: G01N21/77 ,  G01N21/64 ,  C07D515/14 ,  C07D277/22 ,  G01N33/52 ,  G01N31/22

Abstract: Provided are chemosensor compounds of formula (I) useful for detecting an ion, such as Pb2+ in an aqueous sample. Also provided are a chemosensor device including such compounds and methods of use thereof.