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公开(公告)号：US10907010B2
公开(公告)日：2021-02-02
申请号：US16351383
申请日：2019-03-12
摘要： The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.
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公开(公告)号：US10273327B2
公开(公告)日：2019-04-30
申请号：US15506578
申请日：2015-09-03
摘要： The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.
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公开(公告)号：US10066119B2
公开(公告)日：2018-09-04
申请号：US14991884
申请日：2016-01-08
发明人： Andrew J. Boydston , Mark A. Ganter , Duane Storti , Adam Edward Goetz , Mete Yurtoglu , Michael Byrnes Larsen , Gregory Isaac Peterson , Di Zhang
IPC分类号： B29C71/02 , B29C71/04 , C09D161/16 , B29C64/165 , B29C67/00 , C08G65/48 , C08G67/02 , C08G8/28 , C08J3/24 , C08J3/28 , C08G59/02 , C08G59/68 , C09D163/00 , C08G65/40 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B29K71/00 , B29K105/24 , B29K105/00
摘要： The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using 3D printing. A layer of prepolymer is deposited on a build plate to form a powder bed. The deposited powder bed is heated to about 50° C. to about 170° C. Then, a solution of activating agent is printed on the powder bed in a predetermined pattern, and a stimulus is applied converting the prepolymer to the final polymer. After a predetermined period of time, sequential layers are printed to provide the three-dimensional article. The three-dimensional object can be cured to produce the three-dimensional article composed of the final polymers.
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公开(公告)号：US20160066553A1
公开(公告)日：2016-03-10
申请号：US14850768
申请日：2015-09-10
摘要： The present disclosure is directed to a carbon dioxide-releasing device, including a chamber having a sealable aperture for receiving a first material; a carbon dioxide-releasing polymer disposed within the chamber; and a port for releasing a carbon dioxide generated by the carbon dioxide-releasing polymer from the chamber. The carbon-dioxide releasing polymer can be a self-immolative polymer.
摘要翻译： 本公开涉及一种二氧化碳释放装置，包括具有用于接收第一材料的可密封孔的室; 设置在室内的释放二氧化碳的聚合物; 以及用于从室释放由二氧化碳释放聚合物产生的二氧化碳的端口。 二氧化碳释放聚合物可以是自消泡聚合物。
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公开(公告)号：US20150368403A1
公开(公告)日：2015-12-24
申请号：US14650221
申请日：2013-12-09
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , PACIFIC LUTHERAN UNIVERSITY
发明人： Andrew J. Boydston , Neal A. Yakelis , Ronald Jay Berenson , Derek C. Church , Gregory I. Peterson , Michael Larsen
CPC分类号： C08G71/04 , A61K47/59 , B82Y5/00 , C08G81/028 , C08G85/002
摘要： A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
摘要翻译： 描述了包含自褪色聚合物链段和热活化触发子部分的聚合物。 自褪色聚合物链段包括头端，尾端和多个重复单元。 触发剂部分包括环状加成加合物，其共价偶联于自消除性聚合物片段的头端。 当聚合物暴露于活化温度时，环加成加成物进行逆环加成以释放自消泡聚合物链段。 然后自褪色的聚合物链段分解，从而逐个释放在头尾方向上的重复单元。
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公开(公告)号：US20190211143A1
公开(公告)日：2019-07-11
申请号：US16351383
申请日：2019-03-12
CPC分类号： C08G61/08 , C08G61/12 , C08G61/125 , C08G2261/135 , C08G2261/142 , C08G2261/1422 , C08G2261/1424 , C08G2261/144 , C08G2261/3322 , C08G2261/3324 , C08G2261/3325 , C08G2261/3342 , C08G2261/42 , C08G2261/44 , C08G2261/76 , C08G2261/80
摘要： The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.
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公开(公告)号：US20170240695A1
公开(公告)日：2017-08-24
申请号：US15506578
申请日：2015-09-03
CPC分类号： C08G61/08 , C08G61/12 , C08G61/125 , C08G2261/135 , C08G2261/142 , C08G2261/1422 , C08G2261/1424 , C08G2261/144 , C08G2261/3322 , C08G2261/3324 , C08G2261/3325 , C08G2261/3342 , C08G2261/42 , C08G2261/44 , C08G2261/76 , C08G2261/80
摘要： The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.
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公开(公告)号：US20170225395A1
公开(公告)日：2017-08-10
申请号：US15501721
申请日：2015-08-05
发明人： Andrew J. Boydston , Duane Storti , Mark A. Ganter , Gregory I. Peterson , Michael Larsen , Mete Yurtoglu
CPC分类号： B33Y70/00 , B29C64/106 , B29C64/153 , B29K2995/002 , B33Y10/00 , B33Y80/00
摘要： The present disclosure provides additive manufacturing methods that include depositing onto a substrate a material including a blend of a mechanochromic molecule and a matrix polymer; and fusing the material to provide an article. The mechanochromic molecule has a first end and a second end and includes at least one polymer chain covalently bound to each end.
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公开(公告)号：US20170202874A1
公开(公告)日：2017-07-20
申请号：US15405988
申请日：2017-01-13
CPC分类号： A61K33/00 , A61K41/0028 , A61K47/58 , A61N5/062 , A61N2005/0661
摘要： Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases HNO upon decomposition. In some embodiments, the moiety is in turn linked to an agent to be delivered, such as a therapeutic agent, which is released from the multivalent scaffolds when the moiety decomposes. In some embodiments, the moiety is a 1,2-oxazine moiety. In some embodiments, the multivalent scaffold is a polymer. A plurality of 1,2-oxazine moieties can be covalently bound as side chains to the backbone of the polymer.
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公开(公告)号：US09580553B2
公开(公告)日：2017-02-28
申请号：US14650221
申请日：2013-12-09
申请人： University of Washington through its Center for Commercialization , Pacific Lutheran University
发明人： Andrew J. Boydston , Neal A. Yakelis , Ronald Jay Berenson , Derek C. Church , Gregory I. Peterson , Michael Larsen
CPC分类号： C08G71/04 , A61K47/59 , B82Y5/00 , C08G81/028 , C08G85/002
摘要： A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
摘要翻译： 描述了包含自褪色聚合物链段和热活化触发子部分的聚合物。 自褪色聚合物链段包括头端，尾端和多个重复单元。 触发剂部分包括环状加成加合物，其共价偶联于自消除性聚合物片段的头端。 当聚合物暴露于活化温度时，环加成加成物进行逆环加成以释放自消泡聚合物链段。 然后自褪色的聚合物链段分解，从而逐个释放在头尾方向上的重复单元。
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