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公开(公告)号：US10317390B2
公开(公告)日：2019-06-11
申请号：US14846934
申请日：2015-09-07
Applicant: University of Vienna
Inventor： Alipasha Vaziri , Robert Prevedel
Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.
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2.发明授权公开(公告)号：US09952422B2
公开(公告)日：2018-04-24
申请号：US14996015
申请日：2016-01-14
Applicant: University of Vienna
Inventor： Alipasha Vaziri , Tobias Nöbauer
CPC classification number: G02B21/365 , G02B21/0072 , G02B21/0076 , G02B21/008 , G02B21/367 , G06T7/557 , G06T2207/10052 , H04N13/189 , H04N13/229 , H04N13/232
Abstract: Methods and systems are provided for enhancing the imaging resolution of three dimensional imaging using light field microscopy. A first approach enhances the imaging resolution by modeling the scattering of light that occurs in an imaging target, and using the model to account for the effects of light scattering when de-convolving the light field information to retrieve the 3-dimensional (3D) volumetric information of the imaging target. A second approach enhances the imaging resolution by using a second imaging modality such as two-photon, multi-photon, or confocal excitation microscopy to determine the locations of individual neurons, and using the known neuron locations to enhance the extraction of time series signals from the light field microscopy data.
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Patent Agency Ranking
公开(公告)号：US20160069794A1
公开(公告)日：2016-03-10
申请号：US14846934
申请日：2015-09-07
Applicant: University of Vienna
Inventor： Alipasha Vaziri , Robert Prevedel
IPC: G01N21/25 , G01N33/483
CPC classification number: G01N33/4833 , A61B5/4064 , G01J3/4406 , G01N21/636 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2201/0635 , G01N2201/0697 , G01N2201/1045 , G02B21/02 , G02B21/16 , G02B2207/114
Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.
Abstract translation: 用于记录细胞和/或生物化学过程的动力学的装置和方法，包括包括一个或多个分散元件的装置，其被配置为接收具有不同波长的光谱的脉冲激光束并分散脉冲激光束的光谱; 以及被配置为接收脉冲激光束的分散光谱的一个或多个第一元件，并且通过在脉冲激光束的时间和空间上重新重叠生物样品中的多光子激发区域，使脉冲激光束的分散光谱在生物样品中的一个区域上 样品，其中所述装置被配置为基于所述生物样品中的多光子激发区域的产生，高速地记录所述生物样品的细胞群的细胞和生化过程的变化。
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公开(公告)号：US11988603B2
公开(公告)日：2024-05-21
申请号：US16346339
申请日：2017-10-30
Applicant: UNIVERSITY OF VIENNA
Inventor： Alipasha Vaziri
CPC classification number: G01N21/6408 , G01N21/6458 , G01N21/6486 , G02B21/0076 , G02B21/367 , G01N2201/105 , H01S3/005
Abstract: A tissue imaging system includes a laser module for outputting a laser pulse, an optical delay module configured to split a laser pulse received from the laser module into a plurality of time-delayed sub-pulses, a telescope for delivering the sub-pulses from the optical delay module to a target volume and a photodetector configured to collect photons generated within the target volume in response to excitation of the target volume by the first and second sub-pulses. The system may further include a spatial multiplexing module configured to receive the temporally multiplexed laser pulse from the optical delay module and splitting the temporally multiplexed laser pulse into a plurality of sub-beams including a first sub-beam and a second sub-beam, wherein the first sub-beam and the second sub-beam are spatially separated with respect to a first image plane formed at a first depth within the target volume and with respect to a second image plane formed at a second depth within the target volume.
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公开(公告)号：US11255837B2
公开(公告)日：2022-02-22
申请号：US16421831
申请日：2019-05-24
Applicant: University of Vienna
Inventor： Alipasha Vaziri , Robert Prevedel
Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.
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公开(公告)号：US20200182792A1
公开(公告)日：2020-06-11
申请号：US16346339
申请日：2017-10-30
Applicant: UNIVERSITY OF VIENNA
Inventor： Alipasha Vaziri
Abstract: A tissue imaging system includes a laser module for outputting a laser pulse, an optical delay module configured to split a laser pulse received from the laser module into a plurality of time-delayed sub-pulses, a telescope for delivering the sub-pulses from the optical delay module to a target volume and a photodetector configured to collect photons generated within the target volume in response to excitation of the target volume by the first and second sub-pulses. The system may further include a spatial multiplexing module configured to receive the temporally multiplexed laser pulse from the optical delay module and splitting the temporally multiplexed laser pulse into a plurality of sub-beams including a first sub-beam and a second sub-beam, wherein the first sub-beam and the second sub-beam are spatially separated with respect to a first image plane formed at a first depth within the target volume and with respect to a second image plane formed at a second depth within the target volume.
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公开(公告)号：US20190277827A1
公开(公告)日：2019-09-12
申请号：US16421831
申请日：2019-05-24
Applicant: University of Vienna
Inventor： Alipasha Vaziri , Robert Prevedel
Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.
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