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公开(公告)号：US12123015B2
公开(公告)日：2024-10-22
申请号：US17481085
申请日：2021-09-21
IPC分类号： C12N15/90 , A01H6/46 , A01K67/027 , A61K38/46 , A61K48/00 , C12N9/22 , C12N15/10 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/74 , C12Q1/686 , H01L21/02 , H01L33/00
CPC分类号： C12N15/907 , A01H6/4684 , A01K67/027 , A61K38/465 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/70 , C12N15/746 , C12N15/90 , C12N15/902 , C12Q1/686 , H01L21/02312 , H01L21/02365 , H01L33/0075 , A61K48/00 , C12N2310/11 , C12N2310/13 , C12N2310/14 , C12N2310/20 , C12N2310/31 , C12N2310/32 , C12N2310/33 , C12N2310/3519 , C12N2310/531 , C12N2800/80 , C12Y301/04
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20230201313A1
公开(公告)日：2023-06-29
申请号：US17925581
申请日：2021-05-14
摘要： Disclosed are methods for treatment of a subject with left ventricle hypertrophy. Also disclosed are methods for slowing or delaying progression of left ventricle hypertrophy, as well as methods for mediating cardiac remodeling and for improving cardiac function in subjects with left ventricle hypertrophy. The methods comprise administering etelcalcetide parenterally to a subject.
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公开(公告)号：US20220119846A1
公开(公告)日：2022-04-21
申请号：US17514919
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210388394A1
公开(公告)日：2021-12-16
申请号：US17348596
申请日：2021-06-15
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210310028A1
公开(公告)日：2021-10-07
申请号：US17348590
申请日：2021-06-15
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20210222205A1
公开(公告)日：2021-07-22
申请号：US17220692
申请日：2021-04-01
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10982231B2
公开(公告)日：2021-04-20
申请号：US16935023
申请日：2020-07-21
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K48/00 , A61K38/46 , C12N15/90 , C12Q1/686 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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8.发明申请公开(公告)号：US20200325495A1
公开(公告)日：2020-10-15
申请号：US16898161
申请日：2020-06-10
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10793878B1
公开(公告)日：2020-10-06
申请号：US16892663
申请日：2020-06-04
IPC分类号： C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , C12N15/11 , C12N15/90 , C12Q1/686 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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10.发明申请公开(公告)号：US20200308605A1
公开(公告)日：2020-10-01
申请号：US16859182
申请日：2020-04-27
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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