公开(公告)号：US09879300B2

公开(公告)日：2018-01-30

申请号：US14302238

申请日：2014-06-11

Applicant: UVic Industry Partnerships Inc.

Inventor： Fraser Hof ,  Samuel Minaker ,  Kevin Daze ,  Sara Tabet ,  Manuel Ma

IPC: C12Q1/25 ,  C07C309/43 ,  C07C309/44 ,  C07C309/50 ,  C07C309/60 ,  C12Q1/00 ,  C40B40/12 ,  C40B40/04 ,  G01N33/68

CPC classification number: C12Q1/25 ,  C07C309/43 ,  C07C309/44 ,  C07C309/50 ,  C07C309/60 ,  C07C2603/92 ,  C12Q1/00 ,  C40B40/04 ,  C40B40/12 ,  G01N33/6803 ,  G01N2440/00

Abstract: Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.

公开(公告)号：US20140357503A1

公开(公告)日：2014-12-04

申请号：US14302238

申请日：2014-06-11

Applicant: UVic Industry Partnerships Inc.

Inventor： Fraser Hof ,  Samuel Minaker ,  Kevin Daze ,  Sara Tabet ,  Manuel Ma

IPC: C12Q1/25

CPC classification number: C12Q1/25 ,  C07C309/43 ,  C07C309/44 ,  C07C309/50 ,  C07C309/60 ,  C07C2603/92 ,  C12Q1/00 ,  C40B40/04 ,  C40B40/12 ,  G01N33/6803 ,  G01N2440/00

Abstract: Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.

Abstract translation: 公开的实施例涉及使用包含大环化合物和可检测部分的大环传感器来鉴定或鉴定和定量样品中分析物的阵列。 所公开的阵列可以用于基于不同特征（例如翻译后修饰，异构翻译后修饰和围绕翻译后修饰的肽序列）区分各种分析物。 还公开了用于鉴定包含翻译后修饰的分析物的方法，以及使用所公开的大环传感器的酶测定法。