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公开(公告)号：US10548993B2
公开(公告)日：2020-02-04
申请号：US15500691
申请日：2015-07-30
发明人： Jin Xie , Hongmin Chen , Geoffrey D. Wang
摘要： Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.
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公开(公告)号：US10022451B2
公开(公告)日：2018-07-17
申请号：US14709090
申请日：2015-05-11
发明人： Jin Xie , Zipeng Zhen , Wei Tang
IPC分类号： A61N5/06 , A61K47/48 , A61K31/704 , A61K9/127 , A61K41/00 , A61K33/06 , A61K33/22 , A61K33/26 , A61K33/30
摘要： The subject matter disclosed herein relates to compositions that contain a protein cage and a therapeutic agent, such as a photosensitizer. The protein cage is a protein that binds metal ion. The composition can further contain a cell recognition moiety. The methods disclosed are for permeabilizing the endothelial lining of a cancerous tissue or for treating a cancerous tissue to cause therapeutic injury resulting in the reduction of at least one of the surface area, the depth, and the amount of the tissue affected by the cancerous condition, in a subject.
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公开(公告)号：US20150320885A1
公开(公告)日：2015-11-12
申请号：US14709090
申请日：2015-05-11
发明人： Jin Xie , Zipeng Zhen , Wei Tang
IPC分类号： A61K47/48 , A61N5/06 , A61K9/127 , A61K41/00 , A61K31/704
CPC分类号： A61K47/64 , A61K9/1271 , A61K31/704 , A61K33/06 , A61K33/22 , A61K33/26 , A61K33/30 , A61K41/0057 , A61N5/062 , A61N2005/0662 , A61K2300/00
摘要： The subject matter disclosed herein relates to compositions that contain a protein cage and a therapeutic agent, such as a photosensitizer. The protein cage is a protein that binds metal ion. The composition can further contain a cell recognition moiety. The methods disclosed are for permeabilizing the endothelial lining of a cancerous tissue or for treating a cancerous tissue to cause therapeutic injury resulting in the reduction of at least one of the surface area, the depth, and the amount of the tissue affected by the cancerous condition, in a subject.
摘要翻译： 本文公开的主题涉及含有蛋白质笼和治疗剂的组合物，例如光敏剂。 蛋白质笼是结合金属离子的蛋白质。 组合物还可以含有细胞识别部分。 所公开的方法是用于使癌组织的内皮衬里透化或用于治疗癌组织引起治疗性损伤，导致至少一种受癌症状况影响的组织的表面积，深度和量的减少 ，在一个主题。
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公开(公告)号：US10646570B2
公开(公告)日：2020-05-12
申请号：US15320078
申请日：2015-06-18
发明人： Jin Xie , Hongmin Chen , Geoffrey D. Wang
摘要： Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a photosensitizer embedded in the first shell. Upon irradiation by, for example, X-rays, the nanoparticle can function as a transducer, converting X-ray photons to visible photons, and in turn, activating the photosensitizers. Methods of using the photodynamic therapy system are also disclosed.
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公开(公告)号：US20220096539A1
公开(公告)日：2022-03-31
申请号：US17424109
申请日：2020-01-17
申请人： University of Georgia Research Foundation, Inc. , The University of North Carolina at Chapel Hill
发明人： Jin Xie , Wen Jiang , Trever Todd , Zibo Li
摘要： Particles formed from an alkai metal or alkaline earth metal and halide, for example, sodium and chloride, are provided. The particles can have a hydrophilic coating or external layer, formed of, for example, a polyether-lipid conjugate. In preferred embodiments, the lipid is a phospholipid such as a phosphoethanolamine, and the polyether is a polyethylene glycol such as a PEG amine. Methods making the particles by, for example, a microemulsion reaction, are also provided. Pharmaceutical compositions including a plurality of particles and a pharmaceutically acceptable carrier are also disclosed. Typically the compositions include an effective amount of particles to treat a disease or condition, particularly cancer, in a subject in need thereof. The particles are typically nanoparticles, for example, between about 10 nm and 250 nm and can be monodisperse.
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公开(公告)号：US20230023368A1
公开(公告)日：2023-01-26
申请号：US17774843
申请日：2020-11-05
发明人： Jin Xie , Anil Kumar , Zibo Li
IPC分类号： C07D498/18 , A61K41/00 , A61K47/69 , A61P35/00
摘要： Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.
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公开(公告)号：US20170216464A1
公开(公告)日：2017-08-03
申请号：US15500691
申请日：2015-07-30
发明人： Jin Xie , Hongmin Chen , Geoffrey D. Wang
CPC分类号： A61K49/1866 , A61B5/0035 , A61B5/0071 , A61B5/055 , A61K49/1827 , G01R33/5601
摘要： Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.
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公开(公告)号：US20170209575A1
公开(公告)日：2017-07-27
申请号：US15320078
申请日：2015-06-18
发明人： Jin Xie , Hongmin Chen , Geoffrey D. Wang
CPC分类号： A61K41/008 , A61K41/0057 , A61N5/062 , A61N5/10
摘要： Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a photosensitizer embedded in the first shell. Upon irradiation by, for example, X-rays, the nanoparticle can function as a transducer, converting X-ray photons to visible photons, and in turn, activating the photosensitizers. Methods of using the photodynamic therapy system are also disclosed.
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公开(公告)号：US20170151351A1
公开(公告)日：2017-06-01
申请号：US15361784
申请日：2016-11-28
发明人： Jin Xie , Hongmin Chen , Zibo Li
CPC分类号： A61K49/183 , A61K49/1866 , C01B32/05
摘要： Gd-encapsulated carbonaceous dots (Gd@C-dots) hold great potential in clinical translation as Ti contrast agent for magnetic resonance imaging. However, current synthetic techniques yield particles with poor size control; hence, time-consuming size selection is often needed to obtain particles of desired sizes. Disclosed is a process whereby mesoporous silica nanoparticles are used as templates for size-controlled synthesis of Gd@C-dots. The disclosed methods involve calcining a mixture comprising a mesoporous silica nanoparticle, a gadolinium-containing compound, and a chelator, thereby forming the nanoparticles of gadolinium within the mesoporous silica nanoparticle; and removing the mesoporous silica nanoparticle from the nanoparticles of gadolinium.
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